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How inhibitory control prevents thought intrusions and sensory and motor provocations

Award Number: R01DA026452
ORGANIZATION: NATIONAL INSTITUTE ON DRUG ABUSE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 06/15/2009
PERIOD OF PERFORMANCE END DATE: 11/30/2021

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How inhibitory control prevents thought intrusions and sensory and motor provocations - PROJECT SUMMARY Executive functions underlie our ability to control our behavior according to our goals. One element of executive function is top-down inhibitory control. Over the last funding periods we have distinguished two kinds of inhibitory control – reactive and proactive. Reactive inhibitory control can have broad effects and is driven by stop signals. It is apparently implemented by prefrontal connections to the basal ganglia, which we suppose blocks thalamic drive to cortex. By contrast, proactive inhibitory control is set up in advance of any response and is apparently implemented by sensorimotor cortex, also with downstream effects on basal ganglia and thalamus. Here we leverage our knowledge of these reactive and proactive inhibitory systems to ask how we keep unwanted thoughts out of mind and what mental strategies can be used to reduce pain. Aim 1 tests whether prefrontally-driven reactive inhibitory control prevents thought intrusions. We use the so-called Think/NoThink paradigm in which, on NoThink trials, people have to try to prevent the intrusion of an unwanted memory. We have shown this relates to increased prefrontal beta band power. We do simultaneous EEG/fMRI to localize the prefrontal node that best corresponds with the requirement to Not Think, and we then use fMRI- guided repetitive Transcranial Magnetic Stimulation (TMS) to create a ‘virtual lesion’ of that prefrontal node to test its causal role in preventing intrusions of thought. Aim 2 moves away from reactive inhibitory control to test how proactive inhibitory control reduces subjective pain. We inculcate a proactive inhibitory state (which corresponds to increased sensorimotor beta power) and we then test if, during this state, a nociceptive pain stimulus is rated as less painful subjectively. We then do repetitive TMS to create a ‘virtual lesion’ of M1 (and circuitry) to test the causal role of sensorimotor beta oscillations in a ‘suppressive’ state pertinent to reducing pain ratings. Aim 3 tests whether inculcating a proactive suppression state can prevent thought intrusions. We will do this by embedding the Think/NoThink requirement in task-states characterized by increased beta oscillations. These states are generated either endogenously by the subject given a cue or by the use of beta band entrainment with rTMS.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2022 ( Subtotal = -$129,365 )
2022	2021	UNIVERSITY OF CALIFORNIA, SAN DIEGO	9500 GILMAN DR	LA JOLLA	CA	92093	SAN DIEGO	USA	Drug Use and Addiction Research Programs	000	12	2/7/2022	NON-COMPETING CONTINUATION	$0
2022	2021	UNIVERSITY OF CALIFORNIA, SAN DIEGO	9500 GILMAN DR	LA JOLLA	CA	92093	SAN DIEGO	USA	Drug Use and Addiction Research Programs	001	12	6/21/2022	NON-COMPETING CONTINUATION	-$129,365
														Subtotal = -$129,365

Issue Date FY: 2021 ( Subtotal = $355,312 )
2021	2021	UNIVERSITY OF CALIFORNIA, SAN DIEGO	9500 GILMAN DR	LA JOLLA	CA	92093	SAN DIEGO	USA	Drug Use and Addiction Research Programs	001	12	2/19/2021	NON-COMPETING CONTINUATION	$35,532
2021	2021	UNIVERSITY OF CALIFORNIA, SAN DIEGO	9500 GILMAN DR	LA JOLLA	CA	92093	SAN DIEGO	USA	Drug Use and Addiction Research Programs	000	12	11/18/2020	NON-COMPETING CONTINUATION	$319,780
														Subtotal = $355,312

Issue Date FY: 2020 ( Subtotal = $354,375 )
2020	2020	UNIVERSITY OF CALIFORNIA, SAN DIEGO	9500 GILMAN DR DEPT 621	LA JOLLA	CA	92093	SAN DIEGO	USA	Drug Use and Addiction Research Programs	001	11	12/27/2019	COMPETING CONTINUATION	$354,375
2020	2018	UNIVERSITY OF CALIFORNIA, SAN DIEGO	9500 GILMAN DR DEPT 621	LA JOLLA	CA	92093	SAN DIEGO	USA	Drug Use and Addiction Research Programs	000	10	12/24/2019	NON-COMPETING CONTINUATION	$0
														Subtotal = $354,375

Issue Date FY: 2018 ( Subtotal = $328,938 )
2018	2018	UNIVERSITY OF CALIFORNIA, SAN DIEGO	9500 GILMAN DR DEPT 621	LA JOLLA	CA	92093	SAN DIEGO	USA	Drug Use and Addiction Research Programs	000	10	5/29/2018	NON-COMPETING CONTINUATION	$328,938
														Subtotal = $328,938

Issue Date FY: 2017 ( Subtotal = $328,938 )
2017	2017	UNIVERSITY OF CALIFORNIA, SAN DIEGO	9500 GILMAN DR DEPT 621	LA JOLLA	CA	92093	SAN DIEGO	USA	Drug Use and Addiction Research Programs	000	9	5/23/2017	NON-COMPETING CONTINUATION	$328,938
														Subtotal = $328,938

Issue Date FY: 2016 ( Subtotal = $325,648 )
2016	2016	UNIVERSITY OF CALIFORNIA-SAN DIEGO	9500 GILMAN DRIVE	LA JOLLA	CA	92093	SAN DIEGO	USA	Drug Use and Addiction Research Programs	000	8	5/5/2016	NON-COMPETING CONTINUATION	$325,648
														Subtotal = $325,648

Issue Date FY: 2015 ( Subtotal = $324,003 )
2015	2015	UNIVERSITY OF CALIFORNIA-SAN DIEGO	9500 GILMAN DRIVE	LA JOLLA	CA	92093	SAN DIEGO	USA	Drug Use and Addiction Research Programs	000	7	5/14/2015	NON-COMPETING CONTINUATION	$324,003
														Subtotal = $324,003

Issue Date FY: 2014 ( Subtotal = $342,000 )
2014	2014	UNIVERSITY OF CALIFORNIA-SAN DIEGO	9500 GILMAN DRIVE	LA JOLLA	CA	92093	SAN DIEGO	USA	Drug Use and Addiction Research Programs	000	6	3/10/2014	COMPETING CONTINUATION	$342,000
														Subtotal = $342,000

Issue Date FY: 2013 ( Subtotal = $299,538 )
2013	2013	UNIVERSITY OF CALIFORNIA-SAN DIEGO	9500 GILMAN DRIVE	LA JOLLA	CA	92093	SAN DIEGO	USA	Drug Use and Addiction Research Programs	000	5	5/10/2013	NON-COMPETING CONTINUATION	$299,538
														Subtotal = $299,538

Issue Date FY: 2012 ( Subtotal = $316,451 )
2012	2012	UNIVERSITY OF CALIFORNIA-SAN DIEGO	9500 GILMAN DRIVE	LA JOLLA	CA	92093	SAN DIEGO	USA	Drug Use and Addiction Research Programs	000	4	5/15/2012	NON-COMPETING CONTINUATION	$316,451
														Subtotal = $316,451

Issue Date FY: 2011 ( Subtotal = $325,113 )
2011	2011	UNIVERSITY OF CALIFORNIA-SAN DIEGO	9500 GILMAN DRIVE	LA JOLLA	CA	92093	SAN DIEGO	USA	Drug Use and Addiction Research Programs	000	3	5/12/2011	NON-COMPETING CONTINUATION	$325,113
														Subtotal = $325,113

Issue Date FY: 2010 ( Subtotal = $332,978 )
2010	2010	UNIVERSITY OF CALIFORNIA-SAN DIEGO	9500 GILMAN DRIVE	LA JOLLA	CA	92093	SAN DIEGO	USA	Drug Use and Addiction Research Programs	000	2	5/27/2010	NON-COMPETING CONTINUATION	$332,978
														Subtotal = $332,978

Issue Date FY: 2009 ( Subtotal = $347,540 )
2009	2009	UNIVERSITY OF CALIFORNIA-SAN DIEGO	9500 GILMAN DRIVE	LA JOLLA	CA	92093	SAN DIEGO	USA	Drug Use and Addiction Research Programs	000	1	6/5/2009	NEW	$347,540
														Subtotal = $347,540

Grand Total All Awards = $3,851,469

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How inhibitory control prevents thought intrusions and sensory and motor provocations

Award Number: R01DA026452

ORGANIZATION: NATIONAL INSTITUTE ON DRUG ABUSE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 06/15/2009

PERIOD OF PERFORMANCE END DATE: 11/30/2021

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