Wednesday, January 15, 2025 1/15/2025

Cell-Contact Mediated Mechanisms Assembling Synapses (R01DA022727)

Award Number: R01DA022727
ORGANIZATION: NATIONAL INSTITUTE ON DRUG ABUSE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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Abstract Formation and plasticity of synapses are essential for normal functioning of the brain and key events for learning and adaptive plasticity. Diseases such as addiction, epilepsy, and Alzheimer’s that involve maladaptive plasticity appear to highjack these same mechanisms controlling these events leading to disease states. The area of addition is particular pressing given the devastating impact the disease has on society and the clear like between addictive behaviors and the formation of new synapses and/or maladaptive plastic changes in the brain. Therefore, understanding the mechanisms that regulate normal develop and plasticity in the brain are likely to be critical for any advances in treatment of these diseases. The majority of synaptic contacts that form are made on dendritic spines, which are also a key site of synaptic plasticity. Dendritic spines contain specialized structures called postsynaptic densities (PSDs) that are directly apposed to pre-synaptic neurotransmitter release sites and which scale in size with changes in synaptic strength. Despite having understood this relationship for many years, the molecular dynamics of the translocation and accumulation of PSD proteins and presynaptic proteins following structural plasticity remain poorly understood. Our preliminary data indicate that pre- and postsynaptic proteins for scale in a modular fashion with dendritic spine size. We will determine the synaptic molecular architecture and address how the molecular architecture of the spine synapse responds to structural plasticity in three aims: 1) Determine the nanoarchitecture of glutamate receptors at spine synapses. 2) Determine the nanoscale organization of synchronous and asynchronous synaptic release sites. 3) Determine how PSD-95 nanomodule number and plasticity are regulated. Collectively these studies will advance our understand of basic mechanisms that impact the ability of the nervous system to grow and change, events that are likely central to disease of maladaptive plasticity such as addiction and Alzheimer’s.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $374,330 )
2025	2025	THE ADMINISTRATORS OF TULANE EDUCATIONAL FUND	6823 SAINT CHARLES AVE	NEW ORLEANS	LA	70118	ORLEANS	USA	Drug Use and Addiction Research Programs	002	16	12/10/2024	NON-COMPETING CONTINUATION	$374,330
2025	2024	THE ADMINISTRATORS OF TULANE EDUCATIONAL FUND	6823 SAINT CHARLES AVE	NEW ORLEANS	LA	70118	ORLEANS	USA	Drug Use and Addiction Research Programs	001	15	12/9/2024	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$334,160
2025	2022	THOMAS JEFFERSON UNIVERSITY	1020 WALNUT ST STE 1	PHILADELPHIA	PA	19107	PHILADELPHIA	USA	Drug Use and Addiction Research Programs	000	14	12/9/2024	NON-COMPETING CONTINUATION	-$334,160
														Subtotal = $374,330

Issue Date FY: 2024 ( Subtotal = $415,921 )
2024	2024	ADMINISTRATORS OF THE TULANE EDUCATIONAL FUND, THE	6823 SAINT CHARLES AVE	NEW ORLEANS	LA	70118	ORLEANS	USA	Drug Use and Addiction Research Programs	001	15	5/14/2024	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$415,921
2024	2022	THOMAS JEFFERSON UNIVERSITY	1020 WALNUT ST	PHILADELPHIA	PA	19107	PHILADELPHIA	USA	Drug Use and Addiction Research Programs	000	14	5/14/2024	NON-COMPETING CONTINUATION	$0
														Subtotal = $415,921

Issue Date FY: 2023 ( Subtotal = $0 )
2023	2022	THOMAS JEFFERSON UNIVERSITY	1020 WALNUT ST STE 1	PHILADELPHIA	PA	19107	PHILADELPHIA	USA	Drug Use and Addiction Research Programs	000	14	12/23/2022	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2022 ( Subtotal = $424,077 )
2022	2022	THOMAS JEFFERSON UNIVERSITY	1020 WALNUT ST STE 1	PHILADELPHIA	PA	19107	PHILADELPHIA	USA	Drug Use and Addiction Research Programs	002	14	3/25/2022	NON-COMPETING CONTINUATION	$0
2022	2022	THOMAS JEFFERSON UNIVERSITY	1020 WALNUT ST STE 1	PHILADELPHIA	PA	19107	PHILADELPHIA	USA	Drug Use and Addiction Research Programs	000	14	11/26/2021	NON-COMPETING CONTINUATION	$381,669
2022	2022	THOMAS JEFFERSON UNIVERSITY	1020 WALNUT ST STE 1	PHILADELPHIA	PA	19107	PHILADELPHIA	USA	Drug Use and Addiction Research Programs	001	14	3/24/2022	NON-COMPETING CONTINUATION	$42,408
														Subtotal = $424,077

Issue Date FY: 2021 ( Subtotal = $424,077 )
2021	2021	THOMAS JEFFERSON UNIVERSITY	1020 WALNUT ST STE 1	PHILADELPHIA	PA	19107	PHILADELPHIA	USA	Drug Use and Addiction Research Programs	000	13	11/23/2020	NON-COMPETING CONTINUATION	$381,669
2021	2021	THOMAS JEFFERSON UNIVERSITY	1020 WALNUT ST STE 1	PHILADELPHIA	PA	19107	PHILADELPHIA	USA	Drug Use and Addiction Research Programs	001	13	2/19/2021	NON-COMPETING CONTINUATION	$42,408
														Subtotal = $424,077

Issue Date FY: 2020 ( Subtotal = $424,077 )
2020	2020	THOMAS JEFFERSON UNIVERSITY	1020 WALNUT ST STE 1	PHILADELPHIA	PA	19107	PHILADELPHIA	USA	Drug Use and Addiction Research Programs	000	12	1/28/2020	COMPETING CONTINUATION	$424,077
														Subtotal = $424,077

Issue Date FY: 2019 ( Subtotal = $0 )
2019	2018	THOMAS JEFFERSON UNIVERSITY	1020 WALNUT ST STE 1	PHILADELPHIA	PA	19107	PHILADELPHIA	USA	Drug Use and Addiction Research Programs	000	11	7/18/2019	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2018 ( Subtotal = $310,000 )
2018	2018	THOMAS JEFFERSON UNIVERSITY	1020 WALNUT ST STE 1	PHILADELPHIA	PA	19107	PHILADELPHIA	USA	Drug Use and Addiction Research Programs	000	11	2/23/2018	NON-COMPETING CONTINUATION	$279,000
2018	2018	THOMAS JEFFERSON UNIVERSITY	1020 WALNUT ST STE 1	PHILADELPHIA	PA	19107	PHILADELPHIA	USA	Drug Use and Addiction Research Programs	001	11	4/26/2018	NON-COMPETING CONTINUATION	$31,000
														Subtotal = $310,000

Issue Date FY: 2017 ( Subtotal = $310,000 )
2017	2017	THOMAS JEFFERSON UNIVERSITY	1020 WALNUT ST STE 1	PHILADELPHIA	PA	19107	PHILADELPHIA	USA	Drug Use and Addiction Research Programs	000	10	3/6/2017	NON-COMPETING CONTINUATION	$279,000
2017	2017	THOMAS JEFFERSON UNIVERSITY	1020 WALNUT ST STE 1	PHILADELPHIA	PA	19107	PHILADELPHIA	USA	Drug Use and Addiction Research Programs	001	10	5/22/2017	NON-COMPETING CONTINUATION	$31,000
														Subtotal = $310,000

Issue Date FY: 2016 ( Subtotal = $306,900 )
2016	2016	THOMAS JEFFERSON UNIVERSITY	1020 WALNUT ST	PHILADELPHIA	PA	19107	PHILADELPHIA	USA	Drug Use and Addiction Research Programs	000	9	2/22/2016	NON-COMPETING CONTINUATION	$306,900
														Subtotal = $306,900

Issue Date FY: 2015 ( Subtotal = $305,350 )
2015	2015	THOMAS JEFFERSON UNIVERSITY	1020 WALNUT ST	PHILADELPHIA	PA	19107	PHILADELPHIA	USA	Drug Use and Addiction Research Programs	000	8	2/18/2015	NON-COMPETING CONTINUATION	$305,350
														Subtotal = $305,350

Issue Date FY: 2014 ( Subtotal = $310,000 )
2014	2014	THOMAS JEFFERSON UNIVERSITY	1020 WALNUT ST	PHILADELPHIA	PA	19107	PHILADELPHIA	USA	Drug Use and Addiction Research Programs	000	7	3/5/2014	COMPETING CONTINUATION	$310,000
														Subtotal = $310,000

Issue Date FY: 2012 ( Subtotal = $0 )
2012	2011	THOMAS JEFFERSON UNIVERSITY	1020 WALNUT ST	PHILADELPHIA	PA	19107	PHILADELPHIA	USA	Drug Use and Addiction Research Programs	002	6	8/3/2012	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$0
2012	2011	UNIVERSITY OF PENNSYLVANIA	3451 WALNUT STREET	PHILADELPHIA	PA	19104	PHILADELPHIA	USA	Drug Use and Addiction Research Programs	001	5	1/26/2012	NON-COMPETING CONTINUATION	-$249,588
2012	2011	THOMAS JEFFERSON UNIVERSITY	1020 WALNUT ST	PHILADELPHIA	PA	19107	PHILADELPHIA	USA	Drug Use and Addiction Research Programs	000	6	1/26/2012	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$249,588
														Subtotal = $0

Issue Date FY: 2011 ( Subtotal = $290,843 )
2011	2011	UNIVERSITY OF PENNSYLVANIA	3451 WALNUT STREET	PHILADELPHIA	PA	19104	PHILADELPHIA	USA	Drug Use and Addiction Research Programs	000	5	6/17/2011	NON-COMPETING CONTINUATION	$290,843
														Subtotal = $290,843

Issue Date FY: 2010 ( Subtotal = $300,006 )
2010	2010	UNIVERSITY OF PENNSYLVANIA	3451 WALNUT STREET	PHILADELPHIA	PA	19104	PHILADELPHIA	USA	Drug Use and Addiction Research Programs	000	4	6/17/2010	NON-COMPETING CONTINUATION	$300,006
														Subtotal = $300,006

Issue Date FY: 2009 ( Subtotal = $303,202 )
2009	2009	UNIVERSITY OF PENNSYLVANIA	3451 WALNUT STREET	PHILADELPHIA	PA	19104	PHILADELPHIA	USA	Drug Use and Addiction Research Programs	000	3	7/1/2009	NON-COMPETING CONTINUATION	$303,202
														Subtotal = $303,202

Issue Date FY: 2008 ( Subtotal = $303,362 )
2008	2008	UNIVERSITY OF PENNSYLVANIA	3451 WALNUT STREET	PHILADELPHIA	PA	19104	PHILADELPHIA	USA	Drug Use and Addiction Research Programs	000	2	7/3/2008	NON-COMPETING CONTINUATION	$303,362
														Subtotal = $303,362

Issue Date FY: 2007 ( Subtotal = $309,712 )
2007	2007	UNIVERSITY OF PENNSYLVANIA	3451 WALNUT STREET	PHILADELPHIA	PA	19104	PHILADELPHIA	USA	Drug Use and Addiction Research Programs	000	1	7/23/2007	NEW	$309,712
														Subtotal = $309,712

Grand Total All Awards = $5,111,857

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Cell-Contact Mediated Mechanisms Assembling Synapses (R01DA022727)

Award Number: R01DA022727

ORGANIZATION: NATIONAL INSTITUTE ON DRUG ABUSE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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