Thursday, April 10, 2025 4/10/2025

Human dopamine transporter gene: variation and transcriptional regulation

Award Number: R01DA021409
ORGANIZATION: NATIONAL INSTITUTE ON DRUG ABUSE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

Group Awards By:

View Award Description

Human dopamine transporter gene: variation and transcriptional regulation - The overall goal of this renewal proposal is to dissect genetic transcription mechanisms in the human dopamine transporter gene (hDAT). The dopamine transporter (DAT) regulates the spatio-temporal domains of dopamine neurotransmission by reuptake and release of dopamine and thus contributes to locomotion, motivation, cognition and attention, working memory, behavioral organization and hormone release. It is well recognized that expression of the DAT gene in the brain is highly circumscribed, varies among individual subjects and can be regulated by endogenous and exogenous factors such as substance uses and stress. Altered DAT expression may contribute to hDAT-associated pathophysiological states such as substance use disorders (SUDs). However, information about how hDAT expression is regulated and how DNA sequence variation influences the regulated expression remains largely sporadic. The hypothesis to be tested in this proposal is that novel transcription factors (TFs) play a major role in regulating the hDAT promoter via disorder- associated cis-acting sites. Our preliminary studies show that TFs may regulate the hDAT promoter in an interactive manner. Therefore, three specific aims of this project are to: 1) demonstrate a RNA-protein complex involved in the promoter regulation; 2) confirm a TF-mediated antagonism between 5’ and 3’ cis-acting sites; and 3) identify TFs that bind to two functional VNTRs for promoter regulation. The results will add fundamental knowledge on lead sites through which hDAT is regulated by signaling pathways and confers risks for related brain disorders.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = $410,000 )
2024	2024	THE MCLEAN HOSPITAL CORPORATION	115 MILL ST	BELMONT	MA	02478	MIDDLESEX	USA	Drug Use and Addiction Research Programs	000	15	7/31/2024	NON-COMPETING CONTINUATION	$410,000
														Subtotal = $410,000

Issue Date FY: 2023 ( Subtotal = $0 )
2023	2022	MCLEAN HOSPITAL CORPORATION, THE	115 MILL ST	BELMONT	MA	02478	MIDDLESEX	USA	Drug Use and Addiction Research Programs	000	14	8/22/2023	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2022 ( Subtotal = $409,737 )
2022	2022	MCLEAN HOSPITAL CORPORATION, THE	115 MILL ST	BELMONT	MA	02478	MIDDLESEX	USA	Drug Use and Addiction Research Programs	002	14	7/15/2022	NON-COMPETING CONTINUATION	$410,000
2022	2021	MCLEAN HOSPITAL CORPORATION, THE	115 MILL ST	BELMONT	MA	02478	MIDDLESEX	USA	Drug Use and Addiction Research Programs	001	13	7/13/2022	NON-COMPETING CONTINUATION	$0
2022	2017	MCLEAN HOSPITAL CORPORATION, THE	115 MILL ST	BELMONT	MA	02478	MIDDLESEX	USA	Drug Use and Addiction Research Programs	000	10	6/29/2022	NON-COMPETING CONTINUATION	-$263
														Subtotal = $409,737

Issue Date FY: 2021 ( Subtotal = $410,000 )
2021	2021	MCLEAN HOSPITAL CORPORATION, THE	115 MILL ST	BELMONT	MA	02478	MIDDLESEX	USA	Drug Use and Addiction Research Programs	000	13	8/20/2021	NON-COMPETING CONTINUATION	$410,000
														Subtotal = $410,000

Issue Date FY: 2020 ( Subtotal = $410,000 )
2020	2020	MCLEAN HOSPITAL CORPORATION, THE	115 MILL ST	BELMONT	MA	02478	MIDDLESEX	USA	Drug Use and Addiction Research Programs	002	12	7/30/2020	NON-COMPETING CONTINUATION	$410,000
2020	2019	MCLEAN HOSPITAL CORPORATION, THE	115 MILL ST	BELMONT	MA	02478	MIDDLESEX	USA	Drug Use and Addiction Research Programs	001	11	1/14/2020	COMPETING CONTINUATION	$10,997
2020	2017	MCLEAN HOSPITAL CORPORATION, THE	115 MILL ST	BELMONT	MA	02478	MIDDLESEX	USA	Drug Use and Addiction Research Programs	000	10	1/14/2020	NON-COMPETING CONTINUATION	-$10,997
														Subtotal = $410,000

Issue Date FY: 2019 ( Subtotal = $410,000 )
2019	2019	MCLEAN HOSPITAL CORPORATION, THE	115 MILL ST	BELMONT	MA	02478	MIDDLESEX	USA	Drug Use and Addiction Research Programs	002	11	7/25/2019	COMPETING CONTINUATION	$410,000
2019	2017	MCLEAN HOSPITAL CORPORATION, THE	115 MILL ST	BELMONT	MA	02478	MIDDLESEX	USA	Drug Use and Addiction Research Programs	000	10	2/21/2019	NON-COMPETING CONTINUATION	$0
2019	2017	MCLEAN HOSPITAL CORPORATION, THE	115 MILL ST	BELMONT	MA	02478	MIDDLESEX	USA	Drug Use and Addiction Research Programs	001	10	7/25/2019	NON-COMPETING CONTINUATION	$0
														Subtotal = $410,000

Issue Date FY: 2017 ( Subtotal = $248,850 )
2017	2017	MCLEAN HOSPITAL CORPORATION, THE	115 MILL ST	BELMONT	MA	02478	MIDDLESEX	USA	Drug Use and Addiction Research Programs	001	10	5/22/2017	NON-COMPETING CONTINUATION	$24,885
2017	2017	MCLEAN HOSPITAL CORPORATION, THE	115 MILL ST	BELMONT	MA	02478	MIDDLESEX	USA	Drug Use and Addiction Research Programs	000	10	3/17/2017	NON-COMPETING CONTINUATION	$223,965
														Subtotal = $248,850

Issue Date FY: 2016 ( Subtotal = $246,361 )
2016	2016	MCLEAN HOSPITAL	115 MILL STREET	BELMONT	MA	02478	MIDDLESEX	USA	Drug Use and Addiction Research Programs	000	9	4/1/2016	EXTENSION WITH OR WITHOUT FUNDS	$246,361
														Subtotal = $246,361

Issue Date FY: 2015 ( Subtotal = $245,116 )
2015	2015	MCLEAN HOSPITAL	115 MILL STREET	BELMONT	MA	02478	MIDDLESEX	USA	Drug Use and Addiction Research Programs	000	8	3/17/2015	NON-COMPETING CONTINUATION	$245,116
														Subtotal = $245,116

Issue Date FY: 2014 ( Subtotal = $248,850 )
2014	2014	MCLEAN HOSPITAL	115 MILL STREET	BELMONT	MA	02478	MIDDLESEX	USA	Drug Use and Addiction Research Programs	000	7	3/21/2014	NON-COMPETING CONTINUATION	$248,850
														Subtotal = $248,850

Issue Date FY: 2013 ( Subtotal = $248,850 )
2013	2013	MCLEAN HOSPITAL	115 MILL STREET	BELMONT	MA	02478	MIDDLESEX	USA	Drug Use and Addiction Research Programs	002	6	6/7/2013	COMPETING CONTINUATION	$248,850
2013	2011	MCLEAN HOSPITAL	115 MILL STREET	BELMONT	MA	02178		USA	Drug Use and Addiction Research Programs	000	5	2/27/2013	NON-COMPETING CONTINUATION	$0
2013	2011	MCLEAN HOSPITAL	115 MILL STREET	BELMONT	MA	02178		USA	Drug Use and Addiction Research Programs	001	5	5/29/2013	NON-COMPETING CONTINUATION	$0
														Subtotal = $248,850

Issue Date FY: 2011 ( Subtotal = $309,281 )
2011	2011	MCLEAN HOSPITAL	115 MILL STREET	BELMONT	MA	02478	MIDDLESEX	USA	Drug Use and Addiction Research Programs	000	5	5/3/2011	NON-COMPETING CONTINUATION	$309,281
														Subtotal = $309,281

Issue Date FY: 2010 ( Subtotal = $312,404 )
2010	2010	MCLEAN HOSPITAL	115 MILL STREET	BELMONT	MA	02478	MIDDLESEX	USA	Drug Use and Addiction Research Programs	000	4	3/30/2010	NON-COMPETING CONTINUATION	$312,404
														Subtotal = $312,404

Issue Date FY: 2009 ( Subtotal = $315,560 )
2009	2009	MCLEAN HOSPITAL	115 MILL STREET	BELMONT	MA	02478	MIDDLESEX	USA	Drug Use and Addiction Research Programs	000	3	4/27/2009	NON-COMPETING CONTINUATION	$315,560
														Subtotal = $315,560

Issue Date FY: 2008 ( Subtotal = $315,560 )
2008	2008	MCLEAN HOSPITAL	115 MILL STREET	BELMONT	MA	02178		USA	Drug Use and Addiction Research Programs	000	2	5/2/2008	NON-COMPETING CONTINUATION	$315,560
														Subtotal = $315,560

Issue Date FY: 2007 ( Subtotal = $322,000 )
2007	2007	MCLEAN HOSPITAL	115 MILL STREET	BELMONT	MA	02178		USA	Drug Use and Addiction Research Programs	000	1	8/28/2007	NEW	$322,000
														Subtotal = $322,000

Grand Total All Awards = $4,862,569

Top

All Categories

About

Search

Reports

Data Submission

Award Information

Human dopamine transporter gene: variation and transcriptional regulation

Award Number: R01DA021409

ORGANIZATION: NATIONAL INSTITUTE ON DRUG ABUSE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

Federal Websites

Department of Health & Human Services

HHS Operating Divisions

HHS Staff Divisions

Download A Document Viewer