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FUNCTIONAL GENOMICS OF COCAINE SELF-ADMINISTRATION

Award Number: R01DA013770
ORGANIZATION: NATIONAL INSTITUTE ON DRUG ABUSE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: HEALTH SERVICES
PERIOD OF PERFORMANCE START DATE: 09/30/2000
PERIOD OF PERFORMANCE END DATE: 07/31/2007

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FUNCTIONAL GENOMICS OF COCAINE SELF-ADMINISTRATION - DESCRIPTION (provided by applicant): Cocaine abuse remains a significant societal problem. A central theme of this research program, and the main hypothesis of this renewal application, is that chronic cocaine abuse produces significant changes in CNS gene expression that contribute to clinical issues such as tolerance, sensitization, physical dependence, craving, and withdrawal. Preliminary findings have added to the growing database on cocaine-responsive gene expression in the central nervous system. Experiments are proposed, within the present application, that extend these findings to identify those genes whose expression is altered following an enforced abstinence from cocaine self-administration. To accomplish this, a new behavioral paradigm has been developed in which a binge pattern of cocaine self-administration in rats, followed by a period of abstinence, produces a behavioral sensitization that displays some of the hallmarks of the addictive process in humans. This powerful behavioral model will be examined to identify those genes exhibiting persistent changes in gene expression following cessation of drug administration. The first series of experiments will examine the expression of known cocaine-responsive genes to see if they correlate with the behavioral sensitization. The studies will focus on the nucleus accumbens (core and shell), medial prefrontal cortex, hippocampus, and amygdala as neuroanatomical substrates of the behavioral perturbation. In addition, subsequent studies will concentrate on establishing the temporal course of gene expression to (a) establish the limits of the alterations (how long will they last?), and (b) determine the time at which the changes first become manifest (before or during the abstinence period?). The second series of studies will use new Affymetrix GeneChip technologies (14,280 genes at a time) to identify families of genes that may be coordinately regulated and to identify novel targets of cocaine's effects. The proposed experiments will continue to contribute to our understanding of the role of genomics in establishing and maintaining cocaine addiction.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2006 ( Subtotal = $257,421 )
2006	2006	MILTON S HERSHEY MEDICAL CENTER	500 UNIVERSITY DRIVE, POB 850	HERSHEY	PA	17033	DAUPHIN	USA	Drug Use and Addiction Research Programs	000	8	7/25/2006	NON-COMPETING CONTINUATION	$257,421
														Subtotal = $257,421

Issue Date FY: 2005 ( Subtotal = $263,616 )
2005	2005	MILTON S HERSHEY MEDICAL CENTER	500 UNIVERSITY DRIVE, POB 850	HERSHEY	PA	17033	DAUPHIN	USA	Drug Use and Addiction Research Programs	000	7	7/28/2005	NON-COMPETING CONTINUATION	$263,616
														Subtotal = $263,616

Issue Date FY: 2004 ( Subtotal = $234,274 )
2004	2004	MILTON S HERSHEY MEDICAL CENTER	500 UNIVERSITY DRIVE, POB 850	HERSHEY	PA	17033	DAUPHIN	USA	Drug Use and Addiction Research Programs	000	6	9/13/2004	NON-COMPETING CONTINUATION	$234,274
														Subtotal = $234,274

Issue Date FY: 2003 ( Subtotal = $287,917 )
2003	2003	WAKE FOREST UNIVERSITY HEALTH SCIENCES	MEDICAL CENTER BOULEVARD	WINSTON SALEM	NC	27157	FORSYTH	USA	Drug Use and Addiction Research Programs	000	4	9/30/2003	COMPETING CONTINUATION	$287,917
														Subtotal = $287,917

Issue Date FY: 2002 ( Subtotal = $324,094 )
2002	2002	WAKE FOREST UNIVERSITY SCHOOL OF MEDICINE	MEDICAL CENTER BOULEVARD	WINSTON-SALEM	NC	27157		USA	Drug Use and Addiction Research Programs	000	3	6/14/2002	NON-COMPETING CONTINUATION	$324,094
														Subtotal = $324,094

Issue Date FY: 2001 ( Subtotal = $325,219 )
2001	2001	WAKE FOREST UNIVERSITY SCHOOL OF MEDICINE	MEDICAL CENTER BOULEVARD	WINSTON-SALEM	NC	27157		USA	Drug Use and Addiction Research Programs	000	2	6/6/2001	NON-COMPETING CONTINUATION	$325,219
														Subtotal = $325,219

Issue Date FY: 2000 ( Subtotal = $355,457 )
2000	2000	WAKE FOREST UNIVERSITY SCHOOL OF MEDICINE	MEDICAL CENTER BOULEVARD	WINSTON-SALEM	NC	27157		USA	Drug Use and Addiction Research Programs	000	1	9/28/2000	NEW	$355,457
														Subtotal = $355,457

Grand Total All Awards = $2,047,998

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FUNCTIONAL GENOMICS OF COCAINE SELF-ADMINISTRATION

Award Number: R01DA013770

ORGANIZATION: NATIONAL INSTITUTE ON DRUG ABUSE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: HEALTH SERVICES

PERIOD OF PERFORMANCE START DATE: 09/30/2000

PERIOD OF PERFORMANCE END DATE: 07/31/2007

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