Tuesday, January 14, 2025 1/14/2025

Determinants of Drug Preference in Humans

Award Number: R01DA002812
ORGANIZATION: NATIONAL INSTITUTE ON DRUG ABUSE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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Abstract Drug abuse remains an urgent public health problem. One way to reduce the burden of the problem is to identify risk factors for who will develop drug use problems. The fact that only a few of the many people who experiment with drugs progress to develop problem use suggests that individuals differ in vulnerability. One source of variability is initial response to a drug, at both the behavioral and neural levels. Individuals vary in their initial responses to drugs in ways that predict risk, and these individual differences in drug responses originate, in part, in individual responses in brain function. In this project, we will study individual differences in responses the prototypic stimulant, methamphetamine, by examining both its behavioral rewarding effects and its actions on the brain. Individuals differ in subjective responses to methamphetamine, and preliminary evidence indicates that these differences are related to reactivity of the reward circuit to monetary reward. In this project, we will use fMRI to examine the responses of the striatal-frontal reward circuit to methamphetamine, and determine how individual differences in the neural effects predict behavioral indices of drug liking and reward. First we will obtain indices of neural activity with fMRI after methamphetamine vs placebo: regional activation elicited by a reward task, task-related functional connectivity, and resting state functional connectivity. Then on separate sessions we will obtain indices of the behaviorally rewarding effects of methamphetamine: drug liking, drug (and dose) choice and attentional bias to a drug-paired stimulus. Understanding the relation between the neural response and behavioral response to the drug will extend our understanding of why people differ in positive responses to a stimulant drug.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = $428,682 )
2024	2024	UNIVERSITY OF CHICAGO	5801 S ELLIS AVE	CHICAGO	IL	60637	COOK	USA	Drug Use and Addiction Research Programs	000	41	1/19/2024	NON-COMPETING CONTINUATION	$385,815
2024	2024	UNIVERSITY OF CHICAGO	5801 S ELLIS AVE	CHICAGO	IL	60637	COOK	USA	Drug Use and Addiction Research Programs	001	41	4/24/2024	NON-COMPETING CONTINUATION	$42,867
														Subtotal = $428,682

Issue Date FY: 2023 ( Subtotal = $490,757 )
2023	2023	UNIVERSITY OF CHICAGO	5801 S ELLIS AVE	CHICAGO	IL	60637	COOK	USA	Drug Use and Addiction Research Programs	000	40	2/14/2023	NON-COMPETING CONTINUATION	$490,757
														Subtotal = $490,757

Issue Date FY: 2022 ( Subtotal = $490,757 )
2022	2022	UNIVERSITY OF CHICAGO, THE	5801 S ELLIS AVE	CHICAGO	IL	60637	COOK	USA	Drug Use and Addiction Research Programs	002	39	1/24/2022	NON-COMPETING CONTINUATION	$441,681
2022	2022	UNIVERSITY OF CHICAGO, THE	5801 S ELLIS AVE	CHICAGO	IL	60637	COOK	USA	Drug Use and Addiction Research Programs	003	39	3/24/2022	NON-COMPETING CONTINUATION	$49,076
2022	2020	UNIVERSITY OF CHICAGO	5801 S ELLIS AVE	CHICAGO	IL	60637	COOK	USA	Drug Use and Addiction Research Programs	001	37	11/2/2021	COMPETING CONTINUATION	$0
2022	2019	UNIVERSITY OF CHICAGO	5801 S ELLIS AVE	CHICAGO	IL	60637	COOK	USA	Drug Use and Addiction Research Programs	000	36	11/2/2021	NON-COMPETING CONTINUATION	$0
														Subtotal = $490,757

Issue Date FY: 2021 ( Subtotal = $495,164 )
2021	2021	UNIVERSITY OF CHICAGO, THE	5801 S ELLIS AVE	CHICAGO	IL	60637	COOK	USA	Drug Use and Addiction Research Programs	000	38	2/5/2021	NON-COMPETING CONTINUATION	$495,164
														Subtotal = $495,164

Issue Date FY: 2020 ( Subtotal = $439,775 )
2020	2020	UNIVERSITY OF CHICAGO, THE	5801 S ELLIS AVE	CHICAGO	IL	60637	COOK	USA	Drug Use and Addiction Research Programs	003	37	6/26/2020	COMPETING CONTINUATION	$426,993
2020	2020	UNIVERSITY OF CHICAGO, THE	5801 S ELLIS AVE	CHICAGO	IL	60637	COOK	USA	Drug Use and Addiction Research Programs	001	37	2/25/2020	COMPETING CONTINUATION	$439,775
2020	2019	UNIVERSITY OF CHICAGO, THE	5801 S ELLIS AVE	CHICAGO	IL	60637	COOK	USA	Drug Use and Addiction Research Programs	000	36	2/25/2020	NON-COMPETING CONTINUATION	$0
2020	2019	UNIVERSITY OF CHICAGO, THE	5801 S ELLIS AVE	CHICAGO	IL	60637	COOK	USA	Drug Use and Addiction Research Programs	002	36	6/26/2020	NON-COMPETING CONTINUATION	-$426,993
														Subtotal = $439,775

Issue Date FY: 2019 ( Subtotal = $568,040 )
2019	2019	UNIVERSITY OF CHICAGO, THE	5801 S ELLIS AVE	CHICAGO	IL	60637	COOK	USA	Drug Use and Addiction Research Programs	000	36	12/1/2018	NON-COMPETING CONTINUATION	$568,040
														Subtotal = $568,040

Issue Date FY: 2018 ( Subtotal = $600,996 )
2018	2018	UNIVERSITY OF CHICAGO, THE	5801 S ELLIS AVE	CHICAGO	IL	60637	COOK	USA	Drug Use and Addiction Research Programs	000	35	11/17/2017	NON-COMPETING CONTINUATION	$540,896
2018	2018	UNIVERSITY OF CHICAGO, THE	5801 S ELLIS AVE	CHICAGO	IL	60637	COOK	USA	Drug Use and Addiction Research Programs	001	35	4/26/2018	NON-COMPETING CONTINUATION	$60,100
														Subtotal = $600,996

Issue Date FY: 2017 ( Subtotal = $604,530 )
2017	2017	UNIVERSITY OF CHICAGO, THE	5801 S ELLIS AVE	CHICAGO	IL	60637	COOK	USA	Drug Use and Addiction Research Programs	001	34	5/22/2017	NON-COMPETING CONTINUATION	$60,454
2017	2017	UNIVERSITY OF CHICAGO, THE	5801 S ELLIS AVE	CHICAGO	IL	60637	COOK	USA	Drug Use and Addiction Research Programs	000	34	12/7/2016	NON-COMPETING CONTINUATION	$544,076
														Subtotal = $604,530

Issue Date FY: 2016 ( Subtotal = $598,148 )
2016	2016	UNIVERSITY OF CHICAGO	1225 EAST 60TH ST	CHICAGO	IL	60637	COOK	USA	Drug Use and Addiction Research Programs	000	33	4/8/2016	NON-COMPETING CONTINUATION	$598,148
														Subtotal = $598,148

Issue Date FY: 2015 ( Subtotal = $603,839 )
2015	2015	UNIVERSITY OF CHICAGO	1225 EAST 60TH ST	CHICAGO	IL	60637	COOK	USA	Drug Use and Addiction Research Programs	000	32	2/5/2015	COMPETING CONTINUATION	$603,839
2015	2014	UNIVERSITY OF CHICAGO	1225 EAST 60TH ST	CHICAGO	IL	60637	COOK	USA	Drug Use and Addiction Research Programs	001	31	2/5/2015	NON-COMPETING CONTINUATION	$0
														Subtotal = $603,839

Issue Date FY: 2014 ( Subtotal = $425,651 )
2014	2014	UNIVERSITY OF CHICAGO	1225 EAST 60TH ST	CHICAGO	IL	60637	COOK	USA	Drug Use and Addiction Research Programs	001	31	2/26/2014	NON-COMPETING CONTINUATION	$42,566
2014	2014	UNIVERSITY OF CHICAGO	1225 EAST 60TH ST	CHICAGO	IL	60637	COOK	USA	Drug Use and Addiction Research Programs	000	31	1/22/2014	NON-COMPETING CONTINUATION	$383,085
														Subtotal = $425,651

Issue Date FY: 2013 ( Subtotal = $550,097 )
2013	2013	UNIVERSITY OF CHICAGO	1225 EAST 60TH ST	CHICAGO	IL	60637	COOK	USA	Drug Use and Addiction Research Programs	002	30	5/17/2013	SUPPLEMENT FOR EXPANSION	$157,840
2013	2013	UNIVERSITY OF CHICAGO	1225 EAST 60TH ST	CHICAGO	IL	60637	COOK	USA	Drug Use and Addiction Research Programs	000	30	1/18/2013	NON-COMPETING CONTINUATION	$367,742
2013	2013	UNIVERSITY OF CHICAGO	1225 EAST 60TH ST	CHICAGO	IL	60637	COOK	USA	Drug Use and Addiction Research Programs	001	30	5/16/2013	NON-COMPETING CONTINUATION	$24,515
														Subtotal = $550,097

Issue Date FY: 2012 ( Subtotal = $411,458 )
2012	2012	UNIVERSITY OF CHICAGO	1225 EAST 60TH ST	CHICAGO	IL	60637	COOK	USA	Drug Use and Addiction Research Programs	000	29	2/1/2012	NON-COMPETING CONTINUATION	$411,458
														Subtotal = $411,458

Issue Date FY: 2011 ( Subtotal = $411,300 )
2011	2011	UNIVERSITY OF CHICAGO	1225 EAST 60TH ST	CHICAGO	IL	60637	COOK	USA	Drug Use and Addiction Research Programs	001	28	5/31/2011	NON-COMPETING CONTINUATION	$29,682
2011	2011	UNIVERSITY OF CHICAGO	1225 EAST 60TH ST	CHICAGO	IL	60637	COOK	USA	Drug Use and Addiction Research Programs	000	28	1/25/2011	NON-COMPETING CONTINUATION	$381,618
														Subtotal = $411,300

Issue Date FY: 2010 ( Subtotal = $0 )
2010	2009	UNIVERSITY OF CHICAGO	1225 EAST 60TH ST	CHICAGO	IL	60637	COOK	USA	Drug Use and Addiction Research Programs	000	27	5/6/2010	COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2009 ( Subtotal = $426,442 )
2009	2009	UNIVERSITY OF CHICAGO	1225 EAST 60TH ST	CHICAGO	IL	60637	COOK	USA	Drug Use and Addiction Research Programs	001	27	7/3/2009	COMPETING CONTINUATION	$426,442
2009	2008	UNIVERSITY OF CHICAGO	1225 EAST 60TH ST	CHICAGO	IL	60637	COOK	USA	Drug Use and Addiction Research Programs	000	26	7/3/2009	NON-COMPETING CONTINUATION	$0
														Subtotal = $426,442

Issue Date FY: 2008 ( Subtotal = $382,009 )
2008	2008	UNIVERSITY OF CHICAGO	1225 EAST 60TH ST	CHICAGO	IL	60637	COOK	USA	Drug Use and Addiction Research Programs	000	26	6/12/2008	NON-COMPETING CONTINUATION	$382,009
														Subtotal = $382,009

Issue Date FY: 2007 ( Subtotal = $397,966 ) (Continued on the next page)
Grand Total All Awards = $11,113,121

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Determinants of Drug Preference in Humans

Award Number: R01DA002812

ORGANIZATION: NATIONAL INSTITUTE ON DRUG ABUSE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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