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Disrupting ATF3/CGRP-IL-6 Neuroimmune Feedback to Overcome Neural Injury–Driven Immunotherapy Resistance in cSCC

Award Number: R01CA311472
ORGANIZATION: NATIONAL CANCER INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 07/01/2026
PERIOD OF PERFORMANCE END DATE: 06/30/2031

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Disrupting ATF3/CGRP-IL-6 Neuroimmune Feedback to Overcome Neural Injury–Driven Immunotherapy Resistance in cSCC - ABSTRACT Perineural invasion (PNI) is a hallmark of aggressive cutaneous squamous cell carcinoma (cSCC) that often necessitates more aggressive treatments and reduces responsiveness to immunotherapy. While the roles of cancer cells in PNI have been studied, the neuronal response to invasion and its impact on the tumor immune microenvironment remain poorly understood. Our preliminary findings reveal that PNI in cSCC triggers neuronal injury and activating transcription factor 3 (ATF3)- dependent transcriptional reprogramming in calcitonin gene-related peptide (CGRP)-positive neurons, leading to resistance to immune checkpoint blockade (ICB). We hypothesize that nerve injury associated with PNI activates ATF3-dependent transcriptional reprogramming in CGRP+ neurons, promoting a protumorigenic inflammatory response primarily through interleukin-6 (IL-6) secretion and polarization of tumor-associated macrophages (TAMs). Our long-term goal is to understand the mechanisms driving cancer dissemination along nerves and develop strategies to prevent this spread while enhancing immunotherapy effectiveness. This proposal pursues three interconnected aims: 1) Investigate how ATF3-mediated transcriptional reprogramming in invaded CGRP+ sensory neurons and aging-impaired neuronal repair drive tumor progression in cSCC; 2) Define how cancer-induced neural injury drives immunotherapy resistance through ATF3-IL-6-mediated phenotypic remodeling of tumor immunity; and 3) Determine how neuronal CGRP-RAMP1 (receptor activity modifying protein 1) signaling in TAMs drives immunotherapy resistance. Our multidisciplinary approach integrates spatial transcriptomics, genetically engineered mouse models, single-cell analyses, and clinical trial samples. We will characterize nerve subtype vulnerability to PNI, examine the age-dependent impairment of neuronal repair, and map the molecular changes in ATF3+ neurons during PNI. Additionally, we will investigate how neuron-derived IL-6 enhances TAM-mediated immunosuppression and evaluate CGRP receptor blockade with FDA-approved compounds like rimegepant. This project redefines tumor-innervating nociceptors from passive bystanders to key inhibitors of antitumor defense. By targeting nerve preservation as a means to overcome immunotherapy resistance, we propose a paradigm shift from neuropeptide-centric approaches to addressing the root cause of resistance: cancer-induced nerve damage. Ultimately, our work will establish tumor innervation as a novel therapeutic target and actionable pillar of cancer care, potentially improving outcomes for patients with PNI-associated malignancies.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $645,865 )
2026	2026	THE UNIVERISTY OF TEXAS M.D. ANDERSON CANCER CENTER	1515 HOLCOMBE BLVD	HOUSTON	TX	77030	HARRIS	USA	Cancer Biology Research	000	1	7/3/2026	NEW	$645,865
														Subtotal = $645,865

Grand Total All Awards = $645,865

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Disrupting ATF3/CGRP-IL-6 Neuroimmune Feedback to Overcome Neural Injury–Driven Immunotherapy Resistance in cSCC

Award Number: R01CA311472

ORGANIZATION: NATIONAL CANCER INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 07/01/2026

PERIOD OF PERFORMANCE END DATE: 06/30/2031

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