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Protoacoustic Imaging for 3D Mapping the Bragg Peak in Real Time during Proton Therapy

Award Number: R01CA309212
ORGANIZATION: NATIONAL CANCER INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 04/02/2026
PERIOD OF PERFORMANCE END DATE: 03/31/2031

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Protoacoustic Imaging for 3D Mapping the Bragg Peak in Real Time during Proton Therapy - Protoacoustic Imaging for 3D Mapping the Bragg Peak in Real Time during Proton Therapy, PI: Shawn (Liangzhong) Xiang Proton therapy is witnessing rapid expansion, with 279,455 patients treated globally by 2021 and nearly 110 centers currently operating worldwide. However, accurately localizing the Bragg peak remains substantial challenge. This can require extending the proton beam beyond the tumor, risking damage to healthy tissues, especially when organ movement occurs during therapy. To tackle these issues, this project will develop a novel imaging technology, protoacoustic imaging, designed to precisely verify the Bragg peak's location in real-time during treatment directly on patient. The initiative will create a dual-modality protoacoustic/ultrasound imaging system to: 1. Precisely monitor the Bragg peak's position. 2. Actively manage organ motion during proton therapy. The project's specific aims include: • Aim 1: Evaluate protoacoustic/ultrasound imaging for Bragg peak localization using animal models. • Aim 2: Develop a protoacoustic/ultrasound imaging system for clinical implementation. • Aim 3: Conduct clinical trials (Phase 0) to validate protoacoustic/ultrasound guidance in patients. Achieving these objectives will enhance the precision of proton therapy, allowing for accurate localization of the Bragg peak and real-time radiation dose adjustments, thus maximizing therapeutic benefits and minimizing risks to patients.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $648,049 )
2026	2026	UNIVERSITY OF CALIFORNIA IRVINE	160 ALDRICH HALL	IRVINE	CA	92697	ORANGE	USA	Cancer Detection and Diagnosis Research	000	1	4/6/2026	NEW	$648,049
														Subtotal = $648,049

Grand Total All Awards = $648,049

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Protoacoustic Imaging for 3D Mapping the Bragg Peak in Real Time during Proton Therapy

Award Number: R01CA309212

ORGANIZATION: NATIONAL CANCER INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 04/02/2026

PERIOD OF PERFORMANCE END DATE: 03/31/2031

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