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Delivery optimization of a transarterial ablative therapy

Award Number: R01CA301555
ORGANIZATION: NATIONAL CANCER INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 03/15/2025
PERIOD OF PERFORMANCE END DATE: 02/28/2030

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Delivery optimization of a transarterial ablative therapy - Project Summary This project will address several important open issues related to transient multiphase ﬂow and heat transfer in biological tissues, including formulation of a class of mathematical models that satisfy conservation laws of multi-constituent chemically reacting ﬂow through porous tissue and stable time-stepping schemes for efﬁcient solution to the highly nonlinear and degenerate coupled governing equations. Mathematical models of chemically reacting miscible ﬂuid ﬂow in living porous tissue will include all relevant phenomena: mass-momentum-energy conservation of multiple chemical species, exothermic chemical reactions during delivery and within the tissue, as well as liquid-gas phase changes induced by exothermic acid-base neutralization reactions. To focus math- ematical model developments, research will develop a class of mathematical models toward understanding the fundamental thermal, hypoxic, and pH response of an exciting thermoembolization therapeutic approach for treat- ing hepatocellular carcinoma (HCC). Mathematical predictions will be validated in an animal model of HCC. The validated models will be used to optimize delivery protocols. The goal of these mathematical sciences efforts is to provide fundamental understanding of mechanisms that deﬁne a successful treatment. Our high-ﬁdelity mathe- matical approach will provide guidance toward the treatment extent that can be achieved for a given combination of patient anatomy, disease extent, chemistry, and injection parameters. Further, the computational methodology is cost effective and helps to reduce and reﬁne animal experiments. A multi-disciplinary team with expertise in imaging physics, mathematical modeling, numerical algorithms, interventional radiology, and biochemistry has been assembled to accomplish project goals.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $474,524 )
2026	2026	THE UNIVERISTY OF TEXAS M.D. ANDERSON CANCER CENTER	1515 HOLCOMBE BLVD	HOUSTON	TX	77030	HARRIS	USA	Cancer Detection and Diagnosis Research	000	2	1/26/2026	NON-COMPETING CONTINUATION	$474,524
														Subtotal = $474,524

Issue Date FY: 2025 ( Subtotal = $536,836 )
2025	2025	THE UNIVERISTY OF TEXAS M.D. ANDERSON CANCER CENTER	1515 HOLCOMBE BLVD	HOUSTON	TX	77030	HARRIS	USA	Cancer Detection and Diagnosis Research	000	1	3/11/2025	NEW	$536,836
														Subtotal = $536,836

Grand Total All Awards = $1,011,360

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Delivery optimization of a transarterial ablative therapy

Award Number: R01CA301555

ORGANIZATION: NATIONAL CANCER INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 03/15/2025

PERIOD OF PERFORMANCE END DATE: 02/28/2030

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