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Modeling the role and regulation of reactive stroma in breast ductal carcinoma microinvasions

Award Number: R01CA272601
ORGANIZATION: NATIONAL CANCER INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/01/2022
PERIOD OF PERFORMANCE END DATE: 08/31/2027

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Modeling the role and regulation of reactive stroma in breast ductal carcinoma microinvasions - Ductal carcinoma in situ (DCIS) of the breast is a heterogeneous group of neoplastic lesions confined to the mammary ducts. Reactive stroma emerges during early breast cancer development and co-evolves with breast cancer progression. While genetic alterations during breast carcinogenesis have been extensively studied, more in-depth investigation is needed into the non-genetic microenvironmental factors that select for these genotypes. We hypothesize that emergence of reactive stroma precedes initiation of microinvasion, and that this process is an effect of a modified tissue metabolic landscape. This hypothesis will be tested using the interdisciplinary approach by explicitly integrating experimental and computational models that together are able to handle this problem complexity. We have assembled a multidisciplinary team of investigators to quantify tumor cell-stroma interactions under different metabolic conditions (aim 1); assess the role of reactive stroma in DCIS upgrading (aim 2); and evaluate reactive stroma signatures in DCIS histology (aim 3). We will pursue these aims by using a comprehensive approach that combines studies of DCIS histology samples, three-dimensional (3D) tumor organoid cultures, mathematical modeling of complex tumor microenvironment, and quantitative algorithms applied to medical imaging. Our goal is to define novel molecular and physical signatures of reactive stoma with a goal to improve preventive and therapeutic strategies.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = $551,254 )
2024	2024	H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE HOSPITAL, INC.	12902 USF MAGNOLIA DR	TAMPA	FL	33612	HILLSBOROUGH	USA	Cancer Biology Research	000	3	8/15/2024	NON-COMPETING CONTINUATION	$551,254
														Subtotal = $551,254

Issue Date FY: 2023 ( Subtotal = $568,661 )
2023	2023	H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE HOSPITAL, INC.	12902 MAGNOLIA DR	TAMPA	FL	33612	HILLSBOROUGH	USA	Cancer Biology Research	000	2	8/25/2023	NON-COMPETING CONTINUATION	$568,661
														Subtotal = $568,661

Issue Date FY: 2022 ( Subtotal = $597,391 )
2022	2022	H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE HOSPITAL, INC.	12902 MAGNOLIA DR	TAMPA	FL	33612	HILLSBOROUGH	USA	Cancer Biology Research	000	1	9/1/2022	NEW	$597,391
														Subtotal = $597,391

Grand Total All Awards = $1,717,306

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Modeling the role and regulation of reactive stroma in breast ductal carcinoma microinvasions

Award Number: R01CA272601

ORGANIZATION: NATIONAL CANCER INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/01/2022

PERIOD OF PERFORMANCE END DATE: 08/31/2027

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