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Aggressive colorectal cancer subtypes and social disadvantage in a racially diverse cohort

Award Number: R01CA259420
ORGANIZATION: NATIONAL CANCER INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 06/01/2021
PERIOD OF PERFORMANCE END DATE: 12/31/2026

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Aggressive colorectal cancer subtypes and social disadvantage in a racially diverse cohort - ABSTRACT While overall colorectal cancer (CRC) incidence and mortality have declined over the last several decades, CRC incidence and mortality rates continue to be higher in African Americans (AAs) than non-Hispanic Whites (NHW). Consensus CRC molecular tumor subtypes are important indicators of carcinogenic pathway and prognosis, and area associated with specific somatic gene mutations, mismatch repair (MMR) phenotype, and gene-specific methylation, although it is currently unknown whether racial differences in these subtypes underlie racial disparities in CRC survival as these subtypes were derived from studies largely comprised of NHW CRCs. The relative contributions of genetic, behavioral and environmental factors on CRC-related outcomes in AA individuals remain largely unknown and there is a critical need for information about pathogenesis to improve approaches to screening and treatment. This is especially true for area-level socioeconomic factors, such as income and housing values, that are associated with higher risk of CRC but for which the biologic consequences are not yet known. The overall goal of the study is to identify genomic and social factors associated with CRC pathogenesis in a well-characterized cohort of AA CRC cases. We hypothesize that tumor biology, here defined by somatic and epigenetic alterations in tumors, explains a substantial proportion of the racial disparities in CRC outcomes, and area-level factors modify this relationship. Our long-term goal is to improve our ability to diagnose, treat and prevent CRC through a comprehensive understanding of the molecular events in tumors that arise in diverse populations.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $798,024 )
2025	2025	GEORGETOWN UNIVERSITY	MAIN CAMPUS	WASHINGTON	DC	20057	DISTRICT OF COLUMBIA	USA	Cancer Cause and Prevention Research	001	5	1/13/2025	SUPPLEMENT FOR EXPANSION	$163,842
2025	2025	GEORGETOWN UNIVERSITY	MAIN CAMPUS	WASHINGTON	DC	20057	DISTRICT OF COLUMBIA	USA	Cancer Cause and Prevention Research	000	5	12/30/2024	NON-COMPETING CONTINUATION	$570,764
2025	2025	GEORGETOWN UNIVERSITY	MAIN CAMPUS	WASHINGTON	DC	20057	DISTRICT OF COLUMBIA	USA	Cancer Cause and Prevention Research	002	5	6/4/2025	NON-COMPETING CONTINUATION	$63,418
														Subtotal = $798,024

Issue Date FY: 2024 ( Subtotal = $715,103 )
2024	2024	GEORGETOWN UNIVERSITY	MAIN CAMPUS	WASHINGTON	DC	20057	DISTRICT OF COLUMBIA	USA	Cancer Cause and Prevention Research	002	4	8/12/2024	SUPPLEMENT FOR EXPANSION	$154,306
2024	2024	GEORGETOWN UNIVERSITY	MAIN CAMPUS	WASHINGTON	DC	20057	DISTRICT OF COLUMBIA	USA	Cancer Cause and Prevention Research	001	4	4/17/2024	NON-COMPETING CONTINUATION	$29,515
2024	2024	GEORGETOWN UNIVERSITY	MAIN CAMPUS	WASHINGTON	DC	20057	DISTRICT OF COLUMBIA	USA	Cancer Cause and Prevention Research	000	4	1/22/2024	NON-COMPETING CONTINUATION	$531,282
														Subtotal = $715,103

Issue Date FY: 2023 ( Subtotal = $0 )
2023	2022	GEORGETOWN UNIVERSITY	MAIN CAMPUS	WASHINGTON	DC	20057	DISTRICT OF COLUMBIA	USA	Cancer Cause and Prevention Research	004	3	6/13/2023	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$229,443
2023	2022	REGENTS OF THE UNIVERSITY OF MICHIGAN	503 THOMPSON STREET	ANN ARBOR	MI	48109	WASHTENAW	USA	Cancer Cause and Prevention Research	000	2	5/4/2023	NON-COMPETING CONTINUATION	-$615,500
2023	2022	GEORGETOWN UNIVERSITY	MAIN CAMPUS	WASHINGTON	DC	20057	DISTRICT OF COLUMBIA	USA	Cancer Cause and Prevention Research	001	3	5/4/2023	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$615,500
2023	2022	GEORGETOWN UNIVERSITY	MAIN CAMPUS	WASHINGTON	DC	20057	DISTRICT OF COLUMBIA	USA	Cancer Cause and Prevention Research	005	3	7/27/2023	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$0
2023	2022	REGENTS OF THE UNIVERSITY OF MICHIGAN	1109 GEDDES AVE, SUITE 3300	ANN ARBOR	MI	48109	WASHTENAW	USA	Cancer Cause and Prevention Research	003	2	6/13/2023	NON-COMPETING CONTINUATION	-$1
2023	2021	REGENTS OF THE UNIVERSITY OF MICHIGAN	1109 GEDDES AVE, SUITE 3300	ANN ARBOR	MI	48109	WASHTENAW	USA	Cancer Cause and Prevention Research	002	1	6/13/2023	NEW	-$229,442
														Subtotal = $0

Issue Date FY: 2022 ( Subtotal = $615,501 )
2022	2022	REGENTS OF THE UNIVERSITY OF MICHIGAN	503 THOMPSON ST	ANN ARBOR	MI	48109	WASHTENAW	USA	Cancer Cause and Prevention Research	000	2	6/17/2022	NON-COMPETING CONTINUATION	$615,501
														Subtotal = $615,501

Issue Date FY: 2021 ( Subtotal = $655,222 )
2021	2021	REGENTS OF THE UNIVERSITY OF MICHIGAN	503 THOMPSON ST	ANN ARBOR	MI	48109	WASHTENAW	USA	Cancer Cause and Prevention Research	000	1	5/27/2021	NEW	$655,222
														Subtotal = $655,222

Grand Total All Awards = $2,783,850

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Aggressive colorectal cancer subtypes and social disadvantage in a racially diverse cohort

Award Number: R01CA259420

ORGANIZATION: NATIONAL CANCER INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 06/01/2021

PERIOD OF PERFORMANCE END DATE: 12/31/2026

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