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Elucidation of the genetic mechanisms driving prostate tumorigenesis through integrative computational and functional approaches

Award Number: R01CA251555
ORGANIZATION: NATIONAL CANCER INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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Elucidation of the genetic mechanisms driving prostate tumorigenesis through integrative computational and functional approaches - PROJECT SUMMARY/ABSTRACT Although genome-wide association studies (GWAS) have been extremely successful in identifying numerous germline variants associated to risk for prostate cancer, the causal mechanism between genetic variation and disease risk remains largely unknown at the vast majority of these loci. This prohibits the full realization of novel drug targets and/or personalized treatments. In the quest to address this gap, post-GWAS studies are experiencing a “big data” revolution driven by the exponentially decreasing costs of high-throughput genomic assays. Multiple layers of data (genetic variation, transcriptome levels, epigenetic modifications, localization of tissue-specific regulatory sites, 3D interactions, etc.) are routinely collected in increasingly large cohorts of individuals. This raises the need for rigorous computational and experimental frameworks that integrate various types of data to identify and validate causal genes and variants in prostate cancer. Here we propose a rigorous framework aimed at loci where risk is mediated through alteration in gene expression levels. We deliberately and exhaustively propose to examine all risk loci for prostate cancer to prioritize causal variants and genes and to functionally validate them in prostate cancer tissue and cell lines.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $607,593 )
2025	2025	DANA-FARBER CANCER INSTITUTE, INC.	450 BROOKLINE AVE	BOSTON	MA	02215	SUFFOLK	USA	Cancer Cause and Prevention Research	000	5	3/10/2025	NON-COMPETING CONTINUATION	$607,593
														Subtotal = $607,593

Issue Date FY: 2024 ( Subtotal = $641,090 )
2024	2024	DANA-FARBER CANCER INSTITUTE, INC.	450 BROOKLINE AVE	BOSTON	MA	02215	SUFFOLK	USA	Cancer Cause and Prevention Research	001	4	4/24/2024	NON-COMPETING CONTINUATION	$33,743
2024	2024	DANA-FARBER CANCER INSTITUTE, INC.	450 BROOKLINE AVE	BOSTON	MA	02215	SUFFOLK	USA	Cancer Cause and Prevention Research	000	4	3/25/2024	NON-COMPETING CONTINUATION	$607,347
														Subtotal = $641,090

Issue Date FY: 2023 ( Subtotal = $661,392 )
2023	2023	DANA-FARBER CANCER INSTITUTE, INC.	450 BROOKLINE AVE	BOSTON	MA	02115	SUFFOLK	USA	Cancer Cause and Prevention Research	000	3	2/21/2023	NON-COMPETING CONTINUATION	$661,392
														Subtotal = $661,392

Issue Date FY: 2022 ( Subtotal = $660,909 )
2022	2022	DANA-FARBER CANCER INSTITUTE, INC.	450 BROOKLINE AVE	BOSTON	MA	02115	SUFFOLK	USA	Cancer Cause and Prevention Research	000	2	2/17/2022	NON-COMPETING CONTINUATION	$606,955
2022	2022	DANA-FARBER CANCER INSTITUTE, INC.	450 BROOKLINE AVE	BOSTON	MA	02115	SUFFOLK	USA	Cancer Cause and Prevention Research	001	2	5/25/2022	NON-COMPETING CONTINUATION	$53,954
														Subtotal = $660,909

Issue Date FY: 2021 ( Subtotal = $713,783 )
2021	2021	DANA-FARBER CANCER INSTITUTE, INC.	450 BROOKLINE AVE	BOSTON	MA	02115	SUFFOLK	USA	Cancer Cause and Prevention Research	000	1	3/2/2021	NEW	$713,783
														Subtotal = $713,783

Grand Total All Awards = $3,284,767

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Elucidation of the genetic mechanisms driving prostate tumorigenesis through integrative computational and functional approaches

Award Number: R01CA251555

ORGANIZATION: NATIONAL CANCER INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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