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Personalized screening for lung cancer: the importance of co-existing chronic conditions to clinical practice and policy

Award Number: R01CA249506
ORGANIZATION: NATIONAL CANCER INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 06/01/2020
PERIOD OF PERFORMANCE END DATE: 02/28/2027
AWARD TERMINATION DATE: 06/16/2025

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Personalized screening for lung cancer: the importance of co-existing chronic conditions to clinical practice and policy - Abstract / summary Lung cancer is the leading cause of cancer death in the US and worldwide, largely because most patients have advanced, incurable disease at the time of diagnosis. However, lung cancer screening (LCS) with low-dose computed tomography (LDCT) has the potential to revolutionize lung cancer outcomes through early detection. As LCS is disseminated into real-world settings and populations, a key outstanding question is whether the benefits/harms ratio found in clinical trials will apply to an older and sicker population. The basic conundrum facing LCS candidates is that the single risk factor most strongly linked to lung cancer -- smoking history -- is also strongly linked to morbidity and death from non-lung cancer causes (e.g. chronic obstructive pulmonary disease emphysema), which limit life expectancy and increase risk of complications from diagnostic or therapeutic procedures. The overarching goal of our proposed study is to precisely characterize this vulnerable subpopulation with high comorbidity burden, quantifying for them the benefits and harms of LCS to enable more informed decision-making by patients contemplating LCS. Our study will help close this knowledge gap by leveraging real-world data to more fully characterize this subpopulation of “marginal” LCS candidates, reducing the uncertainty currently facing patients and providers. More specifically, we propose to leverage electronic health records and claims data for patients ages 55-80 (n~34,039) undergoing annual screening with LDCT in geographically diverse real-world settings from 2016-2022. We will then use these observational data with validated models in the Cancer Intervention Simulation Network to simulate LCS outcomes in the real-world US population. By generating previously unavailable real-world data for use in validated simulation models, this proposal responds directly to calls to improve patient- centered decision-making in LCS candidates for whom the net benefits of screening are currently highly uncertain.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $0 )
2026	2025	UNIVERSITY OF FLORIDA	1523 UNION RD RM 207	GAINESVILLE	FL	32611	ALACHUA	USA	Cancer Cause and Prevention Research	000	5	1/6/2026	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2025 ( Subtotal = $637,797 )
2025	2025	UNIVERSITY OF FLORIDA	1523 UNION RD RM 207	GAINESVILLE	FL	32611	ALACHUA	USA	Cancer Cause and Prevention Research	002	5	5/22/2025	NON-COMPETING CONTINUATION	$63,779
2025	2025	UNIVERSITY OF FLORIDA	1523 UNION RD RM 207	GAINESVILLE	FL	32611	ALACHUA	USA	Cancer Cause and Prevention Research	000	5	2/13/2025	NON-COMPETING CONTINUATION	$574,018
2025	2025	UNIVERSITY OF FLORIDA	1523 UNION RD RM 207	GAINESVILLE	FL	32611	ALACHUA	USA	Cancer Cause and Prevention Research	001	5	5/1/2025	NON-COMPETING CONTINUATION	$0
2025	2024	UNIVERSITY OF FLORIDA	1523 UNION RD RM 207	GAINESVILLE	FL	32611	ALACHUA	USA	Cancer Cause and Prevention Research	003	4	6/16/2025	TERMINATION	$0
														Subtotal = $637,797

Issue Date FY: 2024 ( Subtotal = $673,788 )
2024	2024	UNIVERSITY OF FLORIDA	1523 UNION RD RM 207	GAINESVILLE	FL	32611	ALACHUA	USA	Cancer Cause and Prevention Research	000	4	2/14/2024	NON-COMPETING CONTINUATION	$576,744
2024	2024	UNIVERSITY OF FLORIDA	1523 UNION RD RM 207	GAINESVILLE	FL	32611	ALACHUA	USA	Cancer Cause and Prevention Research	001	4	3/4/2024	SUPPLEMENT FOR EXPANSION	$61,579
2024	2024	UNIVERSITY OF FLORIDA	1523 UNION RD RM 207	GAINESVILLE	FL	32611	ALACHUA	USA	Cancer Cause and Prevention Research	003	4	4/17/2024	SUPPLEMENT FOR EXPANSION	$3,423
2024	2024	UNIVERSITY OF FLORIDA	1523 UNION RD RM 207	GAINESVILLE	FL	32611	ALACHUA	USA	Cancer Cause and Prevention Research	002	4	4/17/2024	NON-COMPETING CONTINUATION	$32,042
														Subtotal = $673,788

Issue Date FY: 2023 ( Subtotal = $55,355 )
2023	2023	UNIVERSITY OF FLORIDA	1523 UNION RD RM 207	GAINESVILLE	FL	32611	ALACHUA	USA	Cancer Cause and Prevention Research	007	3	9/13/2023	SUPPLEMENT FOR EXPANSION	$55,355
2023	2022	UNIVERSITY OF FLORIDA	1523 UNION RD RM 207	GAINESVILLE	FL	32611	ALACHUA	USA	Cancer Cause and Prevention Research	006	3	9/8/2023	NON-COMPETING CONTINUATION	$0
2023	2021	UNIVERSITY OF FLORIDA	1523 UNION RD RM 207	GAINESVILLE	FL	32611	ALACHUA	USA	Cancer Cause and Prevention Research	003	2	10/22/2022	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	-$535,152
2023	2021	UNIVERSITY OF FLORIDA	1523 UNION RD RM 207	GAINESVILLE	FL	32611	ALACHUA	USA	Cancer Cause and Prevention Research	005	2	3/10/2023	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$535,152
2023	2021	UNIVERSITY OF FLORIDA	1523 UNION RD RM 207	GAINESVILLE	FL	32611	ALACHUA	USA	Cancer Cause and Prevention Research	001	2	10/19/2022	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$535,152
2023	2020	GEORGETOWN UNIVERSITY	MAIN CAMPUS	WASHINGTON	DC	20057	DISTRICT OF COLUMBIA	USA	Cancer Cause and Prevention Research	002	1	10/22/2022	NEW	$535,152
2023	2020	GEORGETOWN UNIVERSITY	MAIN CAMPUS	WASHINGTON	DC	20057	DISTRICT OF COLUMBIA	USA	Cancer Cause and Prevention Research	000	1	10/19/2022	NEW	-$535,152
2023	2020	GEORGETOWN UNIVERSITY	MAIN CAMPUS	WASHINGTON	DC	20057	DISTRICT OF COLUMBIA	USA	Cancer Cause and Prevention Research	004	1	3/10/2023	NEW	-$535,152
														Subtotal = $55,355

Issue Date FY: 2022 ( Subtotal = $626,652 )
2022	2022	UNIVERSITY OF FLORIDA	1523 UNION RD RM 207	GAINESVILLE	FL	32611	ALACHUA	USA	Cancer Cause and Prevention Research	001	3	8/23/2022	NON-COMPETING CONTINUATION	$626,652
2022	2021	UNIVERSITY OF FLORIDA	1523 UNION RD RM 207	GAINESVILLE	FL	32611	ALACHUA	USA	Cancer Cause and Prevention Research	000	2	1/31/2022	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$0
														Subtotal = $626,652

Issue Date FY: 2021 ( Subtotal = $637,512 )
2021	2021	UNIVERSITY OF FLORIDA	1523 UNION RD RM 207	GAINESVILLE	FL	32611	ALACHUA	USA	Cancer Cause and Prevention Research	001	2	9/21/2021	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$637,512
2021	2020	GEORGETOWN UNIVERSITY (THE)	37TH AND O ST NW	WASHINGTON	DC	20057	DISTRICT OF COLUMBIA	USA	Cancer Cause and Prevention Research	000	1	9/20/2021	NEW	$0
														Subtotal = $637,512

Issue Date FY: 2020 ( Subtotal = $689,368 )
2020	2020	GEORGETOWN UNIVERSITY (THE)	37TH AND O ST NW	WASHINGTON	DC	20057	DISTRICT OF COLUMBIA	USA	Cancer Cause and Prevention Research	000	1	6/1/2020	NEW	$689,368
														Subtotal = $689,368

Grand Total All Awards = $3,320,472

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Personalized screening for lung cancer: the importance of co-existing chronic conditions to clinical practice and policy

Award Number: R01CA249506

ORGANIZATION: NATIONAL CANCER INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 06/01/2020

PERIOD OF PERFORMANCE END DATE: 02/28/2027

AWARD TERMINATION DATE: 06/16/2025

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