Monday, February 10, 2025 2/10/2025

Mechanisms and Targeted Therapy of NRF2-high Esophageal Squamous Cell Carcinoma

Award Number: R01CA244236
ORGANIZATION: NATIONAL CANCER INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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This multiple-PI R01 proposal is designed to incorporate genetic and pharmacological approaches to understand the mechanisms of NRF2 hyperactivation in ESCC and to develop targeted therapy for Nrf2high ESCC. We believe Nrf2 and kinases are functionally interrelated, and thus cooperatively contribute to ESCC. In this proposal, we aim to characterize the molecular and phenotypic consequences of NRF2 hyperactivation in ESCC, determine the mechanisms of action and efficacy of NRF2 small molecule inhibitors in ESCC, and identify NRF2-responsive kinases and their functions in NRF2-driven ESCC biology. Through three independent yet tightly related Specific Aims, we will provide novel insights into pathway regulation and novel therapeutic targets/agents for NRF2high ESCC. If proven effective, some compounds may be further translated into the clinic for targeted therapy of NRF2high ESCC in the future.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $556,250 )
2025	2025	CORIELL INSTITUTE FOR MEDICAL RESEARCH, INC.	403 HADDON AVE	CAMDEN	NJ	08103	CAMDEN	USA	Cancer Biology Research	000	6	12/10/2024	NON-COMPETING CONTINUATION	$556,250
2025	2022	NORTH CAROLINA CENTRAL UNIVERSITY	1801 FAYETTEVILLE ST	DURHAM	NC	27707	DURHAM	USA	Cancer Biology Research	001	3	1/15/2025	NON-COMPETING CONTINUATION	-$55,883
2025	2022	NORTH CAROLINA CENTRAL UNIVERSITY	1801 FAYETTEVILLE ST	DURHAM	NC	27707	DURHAM	USA	Cancer Biology Research	002	3	1/15/2025	SUPPLEMENT FOR EXPANSION	-$27,560
2025	2022	CORIELL INSTITUTE FOR MEDICAL RESEARCH, INC.	403 HADDON AVE	CAMDEN	NJ	08103	CAMDEN	USA	Cancer Biology Research	003	4	1/15/2025	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$83,444
														Subtotal = $556,250

Issue Date FY: 2024 ( Subtotal = $794,888 )
2024	2024	CORIELL INSTITUTE FOR MEDICAL RESEARCH, INC.	403 HADDON AVE	CAMDEN	NJ	08103	CAMDEN	USA	Cancer Biology Research	004	5	4/16/2024	SUPPLEMENT FOR EXPANSION	$8,091
2024	2024	CORIELL INSTITUTE FOR MEDICAL RESEARCH, INC.	403 HADDON AVE	CAMDEN	NJ	08103	CAMDEN	USA	Cancer Biology Research	000	5	1/3/2024	NON-COMPETING CONTINUATION	$575,675
2024	2024	CORIELL INSTITUTE FOR MEDICAL RESEARCH, INC.	403 HADDON AVE	CAMDEN	NJ	08103	CAMDEN	USA	Cancer Biology Research	002	5	2/15/2024	SUPPLEMENT FOR EXPANSION	$146,495
2024	2024	CORIELL INSTITUTE FOR MEDICAL RESEARCH, INC.	403 HADDON AVE	CAMDEN	NJ	08103	CAMDEN	USA	Cancer Biology Research	003	5	4/16/2024	NON-COMPETING CONTINUATION	$31,300
2024	2022	CORIELL INSTITUTE FOR MEDICAL RESEARCH, INC.	403 HADDON AVE	CAMDEN	NJ	08103	CAMDEN	USA	Cancer Biology Research	001	4	1/18/2024	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$33,327
														Subtotal = $794,888

Issue Date FY: 2023 ( Subtotal = $0 )
2023	2022	CORIELL INSTITUTE FOR MEDICAL RESEARCH INC	403 HADDON AVE	CAMDEN	NJ	08103	CAMDEN	USA	Cancer Biology Research	001	4	8/1/2023	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$364,093
2023	2022	CORIELL INSTITUTE FOR MEDICAL RESEARCH INC	403 HADDON AVE	CAMDEN	NJ	08103	CAMDEN	USA	Cancer Biology Research	003	4	8/21/2023	SUPPLEMENT FOR EXPANSION	$81,195
2023	2022	NORTH CAROLINA CENTRAL UNIVERSITY	1801 FAYETTEVILLE ST	DURHAM	NC	27707	DURHAM	USA	Cancer Biology Research	000	3	8/1/2023	NON-COMPETING CONTINUATION	-$364,093
2023	2022	NORTH CAROLINA CENTRAL UNIVERSITY	1801 FAYETTEVILLE ST	DURHAM	NC	27707	DURHAM	USA	Cancer Biology Research	002	3	8/21/2023	SUPPLEMENT FOR EXPANSION	-$81,195
														Subtotal = $0

Issue Date FY: 2022 ( Subtotal = $697,927 )
2022	2022	NORTH CAROLINA CENTRAL UNIVERSITY	1801 FAYETTEVILLE ST	DURHAM	NC	27707	DURHAM	USA	Cancer Biology Research	000	3	6/6/2022	NON-COMPETING CONTINUATION	$533,289
2022	2022	NORTH CAROLINA CENTRAL UNIVERSITY	1801 FAYETTEVILLE ST	DURHAM	NC	27707	DURHAM	USA	Cancer Biology Research	001	3	6/22/2022	SUPPLEMENT FOR EXPANSION	$164,638
														Subtotal = $697,927

Issue Date FY: 2021 ( Subtotal = $609,361 )
2021	2021	NORTH CAROLINA CENTRAL UNIVERSITY	1801 FAYETTEVILLE ST	DURHAM	NC	27707	DURHAM	USA	Cancer Biology Research	000	2	5/19/2021	NON-COMPETING CONTINUATION	$553,361
2021	2021	NORTH CAROLINA CENTRAL UNIVERSITY	1801 FAYETTEVILLE ST	DURHAM	NC	27707	DURHAM	USA	Cancer Biology Research	001	2	9/17/2021	NON-COMPETING CONTINUATION	$56,000
														Subtotal = $609,361

Issue Date FY: 2020 ( Subtotal = $574,275 )
2020	2020	NORTH CAROLINA CENTRAL UNIVERSITY	1801 FAYETTEVILLE ST	DURHAM	NC	27707	DURHAM	USA	Cancer Biology Research	000	1	4/13/2020	NEW	$574,275
														Subtotal = $574,275

Grand Total All Awards = $3,232,701

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Mechanisms and Targeted Therapy of NRF2-high Esophageal Squamous Cell Carcinoma

Award Number: R01CA244236

ORGANIZATION: NATIONAL CANCER INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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