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Credentialing a Genetically Engineered Clinically-Relevant Mouse Model of Multiple Myeloma

Award Number: R01CA234181
ORGANIZATION: NATIONAL CANCER INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 12/07/2018
PERIOD OF PERFORMANCE END DATE: 03/31/2024

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Credentialing a Genetically Engineered Clinically-Relevant Mouse Model of Multiple Myeloma - Project Summary/Abstract Thalidomide (Thal) and its derivatives, Lenalidomide (Len) and Pomalidomide (POM), are immune modulatory drugs (IMiDs) used in the treatment of multiple myeloma (MM) and few other hematological malignancies. Although they represent the backbone treatment for both newly diagnosed and relapse/refractory MM patients, their clinical use remains mostly empirical because of lack of suitable in vivo model systems to study their complex mechanisms of action. Murine cells are intrinsically resistant to IMiDs because of different amino acid sequence in the IMiD binding domain of cereblon (CRBN). By building upon our extensively validated Vk*MYC transgenic mouse model of MM, we have generated a novel transgenic mouse, Vk*MYChCRBN, expressing the full human CRBN (hCRBN) gene under the control of its endogenous regulatory elements, rendering it IMiD sensitive. As previously done for the Vk*MYC model, we will extensively characterize the new Vk*MYChCRBN model and will use it to understand the IMiD effects on the tumor and the immune system with the ultimate goal to inform clinical practice.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $0 )
2025	2023	MAYO CLINIC ARIZONA	13400 E SHEA BLVD	SCOTTSDALE	AZ	85259	MARICOPA	USA	Cancer Biology Research	000	5	10/29/2024	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2024 ( Subtotal = $0 )
2024	2023	MAYO CLINIC ARIZONA	13400 E SHEA BLVD	SCOTTSDALE	AZ	85259	MARICOPA	USA	Cancer Biology Research	000	5	8/13/2024	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2023 ( Subtotal = $372,131 )
2023	2023	MAYO CLINIC ARIZONA	13400 E SHEA BLVD	SCOTTSDALE	AZ	85259	MARICOPA	USA	Cancer Biology Research	001	5	3/22/2023	NON-COMPETING CONTINUATION	$30,378
2023	2023	MAYO CLINIC ARIZONA	13400 E SHEA BLVD	SCOTTSDALE	AZ	85259	MARICOPA	USA	Cancer Biology Research	000	5	11/8/2022	NON-COMPETING CONTINUATION	$341,753
														Subtotal = $372,131

Issue Date FY: 2022 ( Subtotal = $372,131 )
2022	2022	MAYO CLINIC ARIZONA	13400 E SHEA BLVD	SCOTTSDALE	AZ	85259	MARICOPA	USA	Cancer Biology Research	000	4	11/16/2021	NON-COMPETING CONTINUATION	$341,752
2022	2022	MAYO CLINIC ARIZONA	13400 E SHEA BLVD	SCOTTSDALE	AZ	85259	MARICOPA	USA	Cancer Biology Research	001	4	4/25/2022	NON-COMPETING CONTINUATION	$30,379
														Subtotal = $372,131

Issue Date FY: 2021 ( Subtotal = $379,725 )
2021	2021	MAYO CLINIC ARIZONA	13400 E SHEA BLVD	SCOTTSDALE	AZ	85259	MARICOPA	USA	Cancer Biology Research	001	3	1/21/2021	NON-COMPETING CONTINUATION	$18,987
2021	2021	MAYO CLINIC ARIZONA	13400 E SHEA BLVD	SCOTTSDALE	AZ	85259	MARICOPA	USA	Cancer Biology Research	000	3	11/30/2020	NON-COMPETING CONTINUATION	$360,738
														Subtotal = $379,725

Issue Date FY: 2020 ( Subtotal = $379,725 )
2020	2020	MAYO CLINIC ARIZONA	13400 E SHEA BLVD	SCOTTSDALE	AZ	85259	MARICOPA	USA	Cancer Biology Research	000	2	11/6/2019	NON-COMPETING CONTINUATION	$341,752
2020	2020	MAYO CLINIC ARIZONA	13400 E SHEA BLVD	SCOTTSDALE	AZ	85259	MARICOPA	USA	Cancer Biology Research	001	2	1/13/2020	NON-COMPETING CONTINUATION	$37,973
														Subtotal = $379,725

Issue Date FY: 2019 ( Subtotal = $379,725 )
2019	2019	MAYO CLINIC ARIZONA	13400 E SHEA BLVD	SCOTTSDALE	AZ	85259	MARICOPA	USA	Cancer Biology Research	000	1	12/7/2018	NEW	$379,725
														Subtotal = $379,725

Grand Total All Awards = $1,883,437

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Credentialing a Genetically Engineered Clinically-Relevant Mouse Model of Multiple Myeloma

Award Number: R01CA234181

ORGANIZATION: NATIONAL CANCER INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 12/07/2018

PERIOD OF PERFORMANCE END DATE: 03/31/2024

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