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Integrating novel GIS and GPS data to assess the impact of built environments on changes in BMI, physical activity and cancer-related biomarkers in two successful weight loss interventions in women at

Award Number: R01CA228147
ORGANIZATION: NATIONAL CANCER INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 04/09/2019
PERIOD OF PERFORMANCE END DATE: 03/31/2025

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Integrating novel GIS and GPS data to assess the impact of built environments on changes in BMI, physical activity and cancer-related biomarkers in two successful weight loss interventions in women at - In 2018, 266,120 new cases of invasive breast cancer are expected. The Breast Cancer and Environment Research Program, funded by NIEHS and NCI, identified a need to better understand environmental exposures to inform cancer prevention efforts. Further, Just in Time Adaptive Interventions (JITAIs) employ temporal and spatial cues to prompt behavior change, but little is known about spatial predictors of behaviors at the minute level and beyond home neighborhoods. Two successful weight loss trials in women at risk for breast cancer, conducted in harmony under the NCI-funded Transdisciplinary Research and Energetics in Cancer Center, offer a unique opportunity to examine the health impacts of changing environmental exposures in a heterogeneous sample. One trial focused on older breast cancer survivors, the other on women across the age range at increased breast cancer risk due to their obesity status. The studies included numerous identical measures at baseline and 6 months, including biomarkers, GPS and accelerometer measurements, and perceived environment surveys. We propose to investigate the relationship between minute level objective GIS measured walkability, greenspace, pollution and food environments and changes in BMI, physical activity (PA), and cancer related biomarkers. Few studies have assessed the impact of the built environment on weight loss interventions using objective daily measures, and none included biomarkers of cancer risk. Further, no studies have employed novel GPS measures of total environment exposure that can change as behaviors change in an intervention. Assessing the effects of built environments on intervention outcomes and investigating changes in exposure over time will provide more causal evidence to inform the policy agenda. Most data on built environment and health are cross sectional. We need longitudinal, causal evidence to support policy changes in urban design that will have lasting impact on large population groups and those at risk, recommended by the WHO, IOM and CDC. In addition, we will use estimates of exposure change from the current study to simulate the potential impact of JITAIs and to identify decision points, decision rules and tailoring variables for future interventions. The current study will geocode each GPS coordinate (42 million), integrate built environment data on walkability, greenspace, pollution and food environments in GIS using validated integrated data analysis techniques, and investigate whether the environment influences changes in biomarkers, BMI and PA. The Ecological model posits that factors at the individual, interpersonal, and community level can influence behavior and health. These analyses will assess the multi-level predictors, while adjusting for interpersonal and individual covariates. Results will be disseminated to existing community partners from cancer, aging and transportation planning to inform local advocacy efforts. This study will also inform future RCTs controlling for individual and environmental predictors at baseline and inform JITAIs by developing and testing minute level spatial, temporal and behavioral rules.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = -$9,232 )
2025	2024	UNIVERSITY OF CALIFORNIA, SAN DIEGO	9500 GILMAN DR	LA JOLLA	CA	92093	SAN DIEGO	USA	Cancer Detection and Diagnosis Research	000	6	6/25/2025	NON-COMPETING CONTINUATION	-$9,232
														Subtotal = -$9,232

Issue Date FY: 2024 ( Subtotal = $122,632 )
2024	2024	UNIVERSITY OF CALIFORNIA, SAN DIEGO	9500 GILMAN DR	LA JOLLA	CA	92093	SAN DIEGO	USA	Cancer Detection and Diagnosis Research	000	6	4/11/2024	NON-COMPETING CONTINUATION	$122,632
														Subtotal = $122,632

Issue Date FY: 2023 ( Subtotal = $446,672 )
2023	2023	UNIVERSITY OF CALIFORNIA, SAN DIEGO	9500 GILMAN DRIVE	LA JOLLA	CA	92093	SAN DIEGO	USA	Cancer Detection and Diagnosis Research	000	5	3/28/2023	NON-COMPETING CONTINUATION	$446,672
														Subtotal = $446,672

Issue Date FY: 2022 ( Subtotal = $391,534 )
2022	2022	UNIVERSITY OF CALIFORNIA, SAN DIEGO	9500 GILMAN DR	LA JOLLA	CA	92093	SAN DIEGO	USA	Cancer Detection and Diagnosis Research	001	4	5/26/2022	NON-COMPETING CONTINUATION	$176,492
2022	2022	UNIVERSITY OF CALIFORNIA, SAN DIEGO	9500 GILMAN DR	LA JOLLA	CA	92093	SAN DIEGO	USA	Cancer Detection and Diagnosis Research	000	4	5/3/2022	NON-COMPETING CONTINUATION	$215,042
														Subtotal = $391,534

Issue Date FY: 2021 ( Subtotal = $549,222 )
2021	2021	UNIVERSITY OF CALIFORNIA, SAN DIEGO	9500 GILMAN DR	LA JOLLA	CA	92093	SAN DIEGO	USA	Cancer Detection and Diagnosis Research	001	3	3/26/2021	NON-COMPETING CONTINUATION	$549,222
2021	2020	UNIVERSITY OF CALIFORNIA, SAN DIEGO	9500 GILMAN DR	LA JOLLA	CA	92093	SAN DIEGO	USA	Cancer Detection and Diagnosis Research	000	2	3/18/2021	NON-COMPETING CONTINUATION	$0
														Subtotal = $549,222

Issue Date FY: 2020 ( Subtotal = $534,298 )
2020	2020	UNIVERSITY OF CALIFORNIA, SAN DIEGO	9500 GILMAN DR	LA JOLLA	CA	92093	SAN DIEGO	USA	Cancer Detection and Diagnosis Research	000	2	2/21/2020	NON-COMPETING CONTINUATION	$534,298
														Subtotal = $534,298

Issue Date FY: 2019 ( Subtotal = $519,007 )
2019	2019	UNIVERSITY OF CALIFORNIA, SAN DIEGO	9500 GILMAN DR DEPT 621	LA JOLLA	CA	92093	SAN DIEGO	USA	Cancer Detection and Diagnosis Research	000	1	4/9/2019	NEW	$519,007
														Subtotal = $519,007

Grand Total All Awards = $2,554,133

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Integrating novel GIS and GPS data to assess the impact of built environments on changes in BMI, physical activity and cancer-related biomarkers in two successful weight loss interventions in women at

Award Number: R01CA228147

ORGANIZATION: NATIONAL CANCER INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 04/09/2019

PERIOD OF PERFORMANCE END DATE: 03/31/2025

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