Monday, June 30, 2025 6/30/2025

High Performance, Quantitative Breast PET Scanner Integrated With Tomosynthesis

Award Number: R01CA196528
ORGANIZATION: NATIONAL CANCER INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 04/01/2016
PERIOD OF PERFORMANCE END DATE: 11/30/2027

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High Performance, Quantitative Breast PET Scanner Integrated With Tomosynthesis - The long-term objective of this project is to test and refine the use BPET-DBT as a tool for co-registered molecular and anatomic imaging to direct biopsy and deliver personalized breast cancer treatment to patients. The integrated BPET-DBT system acquires PET data in the same (mildly) compressed position immediately after the DBT data acquisition, thereby providing co-registered molecular and anatomical images while also allowing easy patient workflow. The BPET scanner is a dedicated, high spatial resolution, time-of-flight (TOF) breast PET scanner producing quantitative images. The DBT image, in addition to providing superior diagnostic anatomical information, also provides an accurate structural context to the PET image (necessary for guiding biopsy and/or surgical approach based on the PET image) and the means to perform accurate attenuation correction (AC) of the PET data. In this project we will evaluate clinical applications of this novel device using selected cohorts of patients designed to test efficacy of the combined device for surgical guidance, monitoring response to therapy, tissue sampling, and further enhancing the quantitative imaging capability of the device both in hardware and software. Our aims are to: (1) demonstrate imaging capability and utility of this unique device, with two specific clinical situations as demonstration (tumor characterization and margin definition, and residual tumor measurement after neo-adjuvant therapy), (2) develop new quantitative image generation techniques and to evaluate them both retroactively and prospectively in clinical studies, and (3) test DBT-guided biopsy using the PET portion of the image set co-registered to the DBT image to direct stereotactic biopsy. The clinical studies in Aims 1 and 3 will: (i) characterize tumor phenotype and determine tumor margins using 18F-fluoroestradiol (18F-FES) as the biomarker and compare to surgical pathology results and SUV measurements with WB PET-CT, (ii) measure 18F-fluorodeoxyglucose (18F-FDG) uptake in small residual tumor prior to surgery in patients undergoing neoadjuvant chemotherapy and compare BPET-DBT and whole-body PET-CT SUV to histopathology findings post-surgery, and (iii) perform targeted breast biopsy using co-registered 18F-FES BPET-DBT images. In Aim 2 we will: (i) evaluate the performance of the existing TOF reconstruction algorithm in mitigating the limited angle artifacts present in the BPET images, (ii) develop and evaluate new BPET reconstruction and AC methods using image- based resolution modeling (IRM) methods as well as Deep-Learning (DL) methods for direct PET image reconstruction and generation of robust DBT images for PET AC, and (iii) develop and test a new high performance PET detector as an extension to existing BPET detectors for improved images. At the end of the study we expect to have demonstrated the role a high resolution, BPET-DBT scanner can play in the future for personalized breast cancer treatment.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $690,773 )
2025	2025	TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA, THE	3451 WALNUT ST STE 440A	PHILADELPHIA	PA	19104	PHILADELPHIA	USA	Cancer Detection and Diagnosis Research	000	8	11/18/2024	NON-COMPETING CONTINUATION	$621,696
2025	2025	TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA, THE	3451 WALNUT ST STE 440A	PHILADELPHIA	PA	19104	PHILADELPHIA	USA	Cancer Detection and Diagnosis Research	001	8	6/11/2025	NON-COMPETING CONTINUATION	$69,077
														Subtotal = $690,773

Issue Date FY: 2024 ( Subtotal = $656,496 )
2024	2024	TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA, THE	3451 WALNUT ST STE 440A	PHILADELPHIA	PA	19104	PHILADELPHIA	USA	Cancer Detection and Diagnosis Research	002	7	4/16/2024	NON-COMPETING CONTINUATION	$34,551
2024	2024	TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA, THE	3451 WALNUT ST STE 440A	PHILADELPHIA	PA	19104	PHILADELPHIA	USA	Cancer Detection and Diagnosis Research	001	7	11/29/2023	NON-COMPETING CONTINUATION	$621,945
2024	2020	TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA, THE	3451 WALNUT ST STE 440A	PHILADELPHIA	PA	19104	PHILADELPHIA	USA	Cancer Detection and Diagnosis Research	000	5	11/15/2023	NON-COMPETING CONTINUATION	$0
														Subtotal = $656,496

Issue Date FY: 2023 ( Subtotal = $691,319 )
2023	2023	TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA, THE	3451 WALNUT ST STE 440A	PHILADELPHIA	PA	19104	PHILADELPHIA	USA	Cancer Detection and Diagnosis Research	001	6	12/14/2022	COMPETING CONTINUATION	$628,473
2023	2023	TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA, THE	3451 WALNUT ST STE 440A	PHILADELPHIA	PA	19104	PHILADELPHIA	USA	Cancer Detection and Diagnosis Research	002	6	3/15/2023	COMPETING CONTINUATION	$62,846
2023	2020	TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA, THE	3451 WALNUT ST STE 440A	PHILADELPHIA	PA	19104	PHILADELPHIA	USA	Cancer Detection and Diagnosis Research	000	5	12/6/2022	NON-COMPETING CONTINUATION	$0
														Subtotal = $691,319

Issue Date FY: 2022 ( Subtotal = $0 )
2022	2020	TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA, THE	3451 WALNUT ST STE 440A	PHILADELPHIA	PA	19104	PHILADELPHIA	USA	Cancer Detection and Diagnosis Research	000	5	4/5/2022	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2020 ( Subtotal = $582,596 )
2020	2020	TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA, THE	3451 WALNUT ST STE 440A	PHILADELPHIA	PA	19104	PHILADELPHIA	USA	Cancer Detection and Diagnosis Research	000	5	3/11/2020	NON-COMPETING CONTINUATION	$582,596
														Subtotal = $582,596

Issue Date FY: 2019 ( Subtotal = $574,476 )
2019	2019	TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA, THE	3451 WALNUT ST STE 440A	PHILADELPHIA	PA	19104	PHILADELPHIA	USA	Cancer Detection and Diagnosis Research	000	4	3/19/2019	NON-COMPETING CONTINUATION	$574,476
														Subtotal = $574,476

Issue Date FY: 2018 ( Subtotal = $637,215 )
2018	2018	TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA, THE	3451 WALNUT ST	PHILADELPHIA	PA	19104	PHILADELPHIA	USA	Cancer Detection and Diagnosis Research	000	3	3/21/2018	NON-COMPETING CONTINUATION	$573,494
2018	2018	TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA, THE	3451 WALNUT ST	PHILADELPHIA	PA	19104	PHILADELPHIA	USA	Cancer Detection and Diagnosis Research	001	3	5/23/2018	NON-COMPETING CONTINUATION	$63,721
														Subtotal = $637,215

Issue Date FY: 2017 ( Subtotal = $679,753 )
2017	2017	TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA, THE	3451 WALNUT ST	PHILADELPHIA	PA	19104	PHILADELPHIA	USA	Cancer Detection and Diagnosis Research	001	2	6/6/2017	NON-COMPETING CONTINUATION	$67,975
2017	2017	TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA, THE	3451 WALNUT ST	PHILADELPHIA	PA	19104	PHILADELPHIA	USA	Cancer Detection and Diagnosis Research	000	2	3/13/2017	NON-COMPETING CONTINUATION	$611,778
														Subtotal = $679,753

Issue Date FY: 2016 ( Subtotal = $673,456 )
2016	2016	UNIVERSITY OF PENNSYLVANIA	3451 WALNUT STREET	PHILADELPHIA	PA	19104	PHILADELPHIA	USA	Cancer Detection and Diagnosis Research	000	1	3/3/2016	NEW	$673,456
														Subtotal = $673,456

Grand Total All Awards = $5,186,084

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High Performance, Quantitative Breast PET Scanner Integrated With Tomosynthesis

Award Number: R01CA196528

ORGANIZATION: NATIONAL CANCER INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 04/01/2016

PERIOD OF PERFORMANCE END DATE: 11/30/2027

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