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(PQA2) MAMMALIAN REGENERATION, HIGH FAT DIETS, AND BREAST CANCER: A COMMON LINK?

Award Number: R01CA180070
ORGANIZATION: NATIONAL CANCER INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 08/16/2013
PERIOD OF PERFORMANCE END DATE: 06/30/2018

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(PQA2) MAMMALIAN REGENERATION, HIGH FAT DIETS, AND BREAST CANCER: A COMMON LINK? - DESCRIPTION (provided by applicant): Obesity, often the result of a high fat diet, leads to chronic inflammation and stromal cell proliferation. In this application, we will address the issue of how a high fat diet leads to enhanced tumor cell growth and approach this from a previously unexplored direction. Examination of an adult mammalian regeneration model employing the MRL/MpJ mouse studied for its susceptibility to autoimmunity, obesity, and enhanced wound healing abilities, displays multiple phenotypes similar to the tumor microenvironment and has been the subject of study in the Heber-Katz laboratory for over a decade. The mapping of genes in this mouse has led to the identification of a novel gene signature defined by a small subset of genes which are regulated by a high fat diet in a sexually dimorphic fashion. The genes that constitute this so-called "high fat-selected regeneration-associated" or HFSRA gene signature are the basis of the proposed approach to defining the mechanistic basis for the association between a high fat diet and breast cancer. This approach is strongly supported by results demonstrating that these same genes are similarly expressed in human breast cancer-derived stromal cells. These studies will utilize the 4T1 orthotopic mouse breast cancer model in syngeneic BALB/c mice in vivo. In vitro studies will be carried out using 3D-culture systems relevant to the tumor microenvironment based on an understanding of the complexities of the tumor microenvironment and the host response to tumors, ranging from the role of stromal cells, inflammation and vascularization to tumor immunity, and is the focus of the Pur¿ laboratory. Working together as a team, the combined expertise of Drs. Heber-Katz and Pur¿ render the important but complex goals of this project eminently feasible.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2022 ( Subtotal = $0 )
2022	2016	LANKENAU INSTITUTE FOR MEDICAL RESEARCH	100 E LANCASTER AVE	WYNNEWOOD	PA	19096	MONTGOMERY	USA	Cancer Biology Research	000	5	10/1/2021	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2019 ( Subtotal = $0 )
2019	2016	LANKENAU INSTITUTE FOR MEDICAL RESEARCH	100 E LANCASTER AVE	WYNNEWOOD	PA	19096	MONTGOMERY	USA	Cancer Biology Research	000	5	12/6/2018	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2016 ( Subtotal = $339,116 )
2016	2016	LANKENAU INSTITUTE FOR MEDICAL RESEARCH	100 LANCASTER AVENUE	WYNNEWOOD	PA	19096	MONTGOMERY	USA	Cancer Biology Research	000	5	6/16/2016	NON-COMPETING CONTINUATION	$339,116
														Subtotal = $339,116

Issue Date FY: 2015 ( Subtotal = $339,116 )
2015	2015	LANKENAU INSTITUTE FOR MEDICAL RESEARCH	100 LANCASTER AVENUE	WYNNEWOOD	PA	19096	MONTGOMERY	USA	Cancer Biology Research	002	4	6/10/2015	NON-COMPETING CONTINUATION	$339,116
2015	2014	WISTAR INSTITUTE	36TH AT SPRUCE	PHILADELPHIA	PA	19104	PHILADELPHIA	USA	Cancer Biology Research	000	2	5/11/2015	NON-COMPETING CONTINUATION	-$222,000
2015	2014	LANKENAU INSTITUTE FOR MEDICAL RESEARCH	100 LANCASTER AVENUE	WYNNEWOOD	PA	19096	MONTGOMERY	USA	Cancer Biology Research	001	3	5/11/2015	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$222,000
														Subtotal = $339,116

Issue Date FY: 2014 ( Subtotal = $345,551 )
2014	2014	WISTAR INSTITUTE	36TH AT SPRUCE	PHILADELPHIA	PA	19104	PHILADELPHIA	USA	Cancer Biology Research	000	2	7/29/2014	NON-COMPETING CONTINUATION	$345,551
														Subtotal = $345,551

Issue Date FY: 2013 ( Subtotal = $377,488 )
2013	2013	WISTAR INSTITUTE	36TH AT SPRUCE	PHILADELPHIA	PA	19104	PHILADELPHIA	USA	Cancer Biology Research	000	1	8/16/2013	NEW	$377,488
														Subtotal = $377,488

Grand Total All Awards = $1,401,271

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(PQA2) MAMMALIAN REGENERATION, HIGH FAT DIETS, AND BREAST CANCER: A COMMON LINK?

Award Number: R01CA180070

ORGANIZATION: NATIONAL CANCER INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 08/16/2013

PERIOD OF PERFORMANCE END DATE: 06/30/2018

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