Thursday, November 21, 2024 11/21/2024

The B7x pathways in the tumor microenvironment

Award Number: R01CA175495
ORGANIZATION: NATIONAL CANCER INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

Group Awards By:

View Award Abstract

The B7x pathway in the tumor microenvironment During the first five years of the R01 funding period (April 2014 – March 2019), we produced 37 publications and received 3 granted patents. We made major discoveries on function and structure of B7x, a much less studied B7 family member that was originally discovered by us. Immune checkpoint blockade of PD-1/PD-L1 and CTLA-4 have advanced the treatment of cancer patients. However, one of the biggest challenges is that the majority of cancer patients do not respond to these treatments. Clearly, new strategies targeting additional immune checkpoints are needed to improve the immunotherapy of human cancers. Our basic and clinical studies and crystal structure analysis suggest B7x immune checkpoint has very different mechanisms and provides an excellent target to develop new immunotherapies. Furthermore, we recently discovered HHLA2 as a homolog of B7x and a new member of the B7 family, which provides a unique opportunity to study a new human immune checkpoint. Thus, our central hypothesis is that B7x and HHLA2, two less-studied members of the B7 family originally discovered by us, are critical immune evasion pathways within the tumor microenvironment and are therapeutic targets for new cancer immunotherapies. This hypothesis will be tested by pursuing three aims: 1) Dissect molecular and cellular mechanisms by which tumor-expressed B7x induces immunosuppression within the tumor microenvironment; 2) Develop new immune checkpoint blockade targeting B7x: Combination therapies and mechanisms; and 3) Elucidate the HHLA2 pathway: A new homology of B7x. We have generated a number of novel tools which provides us with unique opportunities to address challenges and realize goals. The outcomes of this project will reveal new immune evasion mechanisms in the tumor microenvironment and will establish the foundation for clinical design of new immunotherapies, which could potentially be effective in tumors that resist current PD-1/PD-L1 and CTLA-4 targeted therapies.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $359,100 )
2025	2025	ALBERT EINSTEIN COLLEGE OF MEDICINE	1300 MORRIS PARK AVE	BRONX	NY	10461	BRONX	USA	Cancer Biology Research	000	12	11/15/2024	NON-COMPETING CONTINUATION	$359,100
														Subtotal = $359,100

Issue Date FY: 2024 ( Subtotal = $842,276 )
2024	2024	ALBERT EINSTEIN COLLEGE OF MEDICINE	1300 MORRIS PARK AVE	BRONX	NY	10461	BRONX	USA	21st Century Cures Act - Beau Biden Cancer Moonshot	001	11	12/20/2023	SUPPLEMENT FOR EXPANSION	$80,741
2024	2024	ALBERT EINSTEIN COLLEGE OF MEDICINE	1300 MORRIS PARK AVE	BRONX	NY	10461	BRONX	USA	21st Century Cures Act - Beau Biden Cancer Moonshot	003	11	4/18/2024	SUPPLEMENT FOR EXPANSION	$4,485
2024	2024	ALBERT EINSTEIN COLLEGE OF MEDICINE	1300 MORRIS PARK AVE	BRONX	NY	10461	BRONX	USA	Cancer Biology Research	000	11	12/19/2023	NON-COMPETING CONTINUATION	$359,100
2024	2024	ALBERT EINSTEIN COLLEGE OF MEDICINE	1300 MORRIS PARK AVE	BRONX	NY	10461	BRONX	USA	21st Century Cures Act - Beau Biden Cancer Moonshot	002	11	1/24/2024	SUPPLEMENT FOR EXPANSION	$378,000
2024	2024	ALBERT EINSTEIN COLLEGE OF MEDICINE	1300 MORRIS PARK AVE	BRONX	NY	10461	BRONX	USA	Cancer Biology Research	004	11	4/22/2024	NON-COMPETING CONTINUATION	$19,950
														Subtotal = $842,276

Issue Date FY: 2023 ( Subtotal = $842,201 )
2023	2023	ALBERT EINSTEIN COLLEGE OF MEDICINE	1300 MORRIS PARK AVE	BRONX	NY	10461	BRONX	USA	Cancer Biology Research	001	10	12/26/2022	SUPPLEMENT FOR EXPANSION	$80,741
2023	2023	ALBERT EINSTEIN COLLEGE OF MEDICINE	1300 MORRIS PARK AVE	BRONX	NY	10461	BRONX	USA	Cancer Biology Research	002	10	3/20/2023	NON-COMPETING CONTINUATION	-$308,280
2023	2023	ALBERT EINSTEIN COLLEGE OF MEDICINE	1300 MORRIS PARK AVE	BRONX	NY	10461	BRONX	USA	Cancer Biology Research	000	10	12/23/2022	NON-COMPETING CONTINUATION	$699,300
2023	2023	ALBERT EINSTEIN COLLEGE OF MEDICINE	1300 MORRIS PARK AVE	BRONX	NY	10461	BRONX	USA	21st Century Cures Act - Beau Biden Cancer Moonshot	003	10	3/22/2023	SUPPLEMENT FOR EXPANSION	$370,440
														Subtotal = $842,201

Issue Date FY: 2022 ( Subtotal = $817,236 )
2022	2022	ALBERT EINSTEIN COLLEGE OF MEDICINE	1300 MORRIS PARK AVE	BRONX	NY	10461	BRONX	USA	21st Century Cures Act - Beau Biden Cancer Moonshot	003	9	6/29/2022	SUPPLEMENT FOR EXPANSION	$378,000
2022	2022	ALBERT EINSTEIN COLLEGE OF MEDICINE	1300 MORRIS PARK AVE	BRONX	NY	10461	BRONX	USA	Cancer Biology Research	000	9	11/30/2021	NON-COMPETING CONTINUATION	$359,100
2022	2022	ALBERT EINSTEIN COLLEGE OF MEDICINE	1300 MORRIS PARK AVE	BRONX	NY	10461	BRONX	USA	Cancer Biology Research	001	9	5/23/2022	NON-COMPETING CONTINUATION	$31,920
2022	2022	ALBERT EINSTEIN COLLEGE OF MEDICINE	1300 MORRIS PARK AVE	BRONX	NY	10461	BRONX	USA	Cancer Biology Research	002	9	6/1/2022	SUPPLEMENT FOR EXPANSION	$48,216
														Subtotal = $817,236

Issue Date FY: 2021 ( Subtotal = $398,901 )
2021	2021	ALBERT EINSTEIN COLLEGE OF MEDICINE	1300 MORRIS PARK AVE	BRONX	NY	10461	BRONX	USA	Cancer Biology Research	000	8	11/24/2020	COMPETING CONTINUATION	$398,901
														Subtotal = $398,901

Issue Date FY: 2020 ( Subtotal = $0 )
2020	2018	ALBERT EINSTEIN COLLEGE OF MEDICINE	1300 MORRIS PARK AVE	BRONX	NY	10461	BRONX	USA	Cancer Cause and Prevention Research	000	7	9/4/2020	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$0
														Subtotal = $0

Issue Date FY: 2019 ( Subtotal = $0 )
2019	2018	ALBERT EINSTEIN COLLEGE OF MEDICINE	1300 MORRIS PARK AVE	BRONX	NY	10461	BRONX	USA	Cancer Cause and Prevention Research	003	7	2/27/2019	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$11,717
2019	2018	ALBERT EINSTEIN COLLEGE OF MEDICINE, INC.	1300 MORRIS PARK AVE	BRONX	NY	10461	BRONX	USA	Cancer Cause and Prevention Research	000	6	2/11/2019	NON-COMPETING CONTINUATION	-$68,674
2019	2018	ALBERT EINSTEIN COLLEGE OF MEDICINE	1300 MORRIS PARK AVE	BRONX	NY	10461	BRONX	USA	Cancer Cause and Prevention Research	001	7	2/11/2019	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$68,674
2019	2018	ALBERT EINSTEIN COLLEGE OF MEDICINE, INC.	1300 MORRIS PARK AVE	BRONX	NY	10461	BRONX	USA	Cancer Cause and Prevention Research	002	6	2/27/2019	NON-COMPETING CONTINUATION	-$11,717
														Subtotal = $0

Issue Date FY: 2018 ( Subtotal = $346,525 )
2018	2018	ALBERT EINSTEIN COLLEGE OF MEDICINE, INC.	1300 MORRIS PARK AVE	BRONX	NY	10461	BRONX	USA	Cancer Cause and Prevention Research	001	6	5/23/2018	NON-COMPETING CONTINUATION	$34,653
2018	2018	ALBERT EINSTEIN COLLEGE OF MEDICINE, INC.	1300 MORRIS PARK AVE	BRONX	NY	10461	BRONX	USA	Cancer Cause and Prevention Research	000	6	3/12/2018	NON-COMPETING CONTINUATION	$311,872
														Subtotal = $346,525

Issue Date FY: 2017 ( Subtotal = $346,525 )
2017	2017	ALBERT EINSTEIN COLLEGE OF MEDICINE, INC.	1300 MORRIS PARK AVE	BRONX	NY	10461	BRONX	USA	Cancer Cause and Prevention Research	001	5	6/6/2017	NON-COMPETING CONTINUATION	$34,653
2017	2017	ALBERT EINSTEIN COLLEGE OF MEDICINE, INC.	1300 MORRIS PARK AVE	BRONX	NY	10461	BRONX	USA	Cancer Cause and Prevention Research	000	5	3/14/2017	NON-COMPETING CONTINUATION	$311,872
														Subtotal = $346,525

Issue Date FY: 2016 ( Subtotal = $346,525 )
2016	2016	ALBERT EINSTEIN COLLEGE OF MEDICINE INC	111 E 210TH ST	BRONX	NY	10467	BRONX	USA	Cancer Cause and Prevention Research	000	4	4/11/2016	NON-COMPETING CONTINUATION	$346,525
2016	2015	ALBERT EINSTEIN COLLEGE OF MEDICINE INC	111 E 210TH ST	BRONX	NY	10467	BRONX	USA	Cancer Cause and Prevention Research	002	3	5/1/2016	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	-$82,933
2016	2015	ALBERT EINSTEIN COLLEGE OF MEDICINE OF YESHIVA UNIV	1300 MORRIS PARK AVENUE	BRONIX	NY	10461		USA	Cancer Cause and Prevention Research	001	2	5/1/2016	NON-COMPETING CONTINUATION	$82,933
														Subtotal = $346,525

Issue Date FY: 2015 ( Subtotal = $346,525 )
2015	2015	ALBERT EINSTEIN COLLEGE OF MEDICINE OF YESHIVA UNIV	1300 MORRIS PARK AVENUE	BRONIX	NY	10461		USA	Cancer Cause and Prevention Research	000	2	3/20/2015	NON-COMPETING CONTINUATION	$346,525
2015	2015	ALBERT EINSTEIN COLLEGE OF MEDICINE OF YESHIVA UNIV	1300 MORRIS PARK AVENUE	BRONIX	NY	10461		USA	Cancer Cause and Prevention Research	002	2	9/22/2015	NON-COMPETING CONTINUATION	-$318,419
2015	2015	ALBERT EINSTEIN COLLEGE OF MEDICINE INC	111 E 210TH ST	BRONX	NY	10467	BRONX	USA	Cancer Cause and Prevention Research	003	3	9/22/2015	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$318,419
2015	2014	ALBERT EINSTEIN COLLEGE OF MEDICINE OF YESHIVA UNIV	1300 MORRIS PARK AVENUE	BRONIX	NY	10461		USA	Cancer Biology Research	001	1	4/15/2015	SUPPLEMENT FOR EXPANSION	$0
														Subtotal = $346,525

Issue Date FY: 2014 ( Subtotal = $405,600 )
2014	2014	ALBERT EINSTEIN COLLEGE OF MEDICINE OF YESHIVA UNIV	1300 MORRIS PARK AVENUE	BRONIX	NY	10461		USA	Cancer Cause and Prevention Research	000	1	3/13/2014	NEW	$346,525
2014	2014	ALBERT EINSTEIN COLLEGE OF MEDICINE OF YESHIVA UNIV	1300 MORRIS PARK AVENUE	BRONIX	NY	10461		USA	Cancer Biology Research	001	1	7/29/2014	SUPPLEMENT FOR EXPANSION	$59,075
														Subtotal = $405,600

Grand Total All Awards = $5,051,414

Top

All Categories

About

Search

Reports

Data Submission

Award Information

The B7x pathways in the tumor microenvironment

Award Number: R01CA175495

ORGANIZATION: NATIONAL CANCER INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

Federal Websites

Department of Health & Human Services

HHS Operating Divisions

HHS Staff Divisions

Download A Document Viewer