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Therapeutic Targeting of Breast Cancer Tumor Initiating Cells

Award Number: R01CA148761
ORGANIZATION: NATIONAL CANCER INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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Therapeutic Targeting of Breast Cancer Tumor Initiating Cells - PROJECT ABSTRACT Triple Negative Breast Cancer (TNBC), if considered its own disease type, would rank as the 5th leading cause of cancer deaths in women in the USA. The main systemic treatment option for these patients in the adjuvant setting is multi-agent chemotherapy, and now since early 2019, immunotherapy plus chemotherapy is an option for PDL1-positive metastatic patients. TNBC is also known to be biologically heterogeneous, with multiple genomically-defined subtypes present. We hypothesize that much of this heterogeneity actually represents cellular plasticity, and that some TNBC subtypes can actually morph from one subtype into another. We hypothesize that this plasticity is a key determinant of chemotherapy responsiveness, immune checkpoint inhibitor sensitivity, and metastatic potential. Furthermore, we hypothesize that if we are able to keep, or promote, a tumor into the basal-like state, there may be both a change in the immune microenvironment and increased therapy sensitivity. We will test these hypotheses by using novel combinations of drugs, in vitro screens, and in vivo testing of metastasis vs primary tumor sensitivity using Genetically Engineered Mouse models and human tumor specimens.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $371,967 )
2025	2025	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Cancer Treatment Research	000	15	2/28/2025	NON-COMPETING CONTINUATION	$371,967
														Subtotal = $371,967

Issue Date FY: 2024 ( Subtotal = $392,632 )
2024	2024	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Cancer Treatment Research	001	14	4/17/2024	NON-COMPETING CONTINUATION	$20,665
2024	2024	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Cancer Treatment Research	000	14	2/15/2024	NON-COMPETING CONTINUATION	$371,967
														Subtotal = $392,632

Issue Date FY: 2023 ( Subtotal = $413,297 )
2023	2023	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Cancer Treatment Research	000	13	3/15/2023	NON-COMPETING CONTINUATION	$405,031
2023	2023	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Cancer Treatment Research	001	13	9/18/2023	NON-COMPETING CONTINUATION	$8,266
														Subtotal = $413,297

Issue Date FY: 2022 ( Subtotal = $405,031 )
2022	2022	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Cancer Treatment Research	001	12	4/29/2022	NON-COMPETING CONTINUATION	$33,065
2022	2022	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Cancer Treatment Research	000	12	3/23/2022	NON-COMPETING CONTINUATION	$371,966
														Subtotal = $405,031

Issue Date FY: 2021 ( Subtotal = $413,297 )
2021	2021	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Cancer Treatment Research	003	11	7/27/2021	COMPETING CONTINUATION	$62,280
2021	2021	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Cancer Treatment Research	001	11	3/26/2021	COMPETING CONTINUATION	$413,297
2021	2019	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Cancer Cause and Prevention Research	002	10	7/27/2021	NON-COMPETING CONTINUATION	-$62,280
2021	2019	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Cancer Cause and Prevention Research	000	10	3/18/2021	NON-COMPETING CONTINUATION	$0
														Subtotal = $413,297

Issue Date FY: 2019 ( Subtotal = $418,717 )
2019	2019	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Cancer Cause and Prevention Research	000	10	8/12/2019	NON-COMPETING CONTINUATION	$418,717
														Subtotal = $418,717

Issue Date FY: 2018 ( Subtotal = $431,667 )
2018	2018	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Cancer Cause and Prevention Research	000	9	8/10/2018	NON-COMPETING CONTINUATION	$431,667
														Subtotal = $431,667

Issue Date FY: 2017 ( Subtotal = $393,933 )
2017	2017	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Cancer Cause and Prevention Research	000	8	7/21/2017	NON-COMPETING CONTINUATION	$393,933
														Subtotal = $393,933

Issue Date FY: 2016 ( Subtotal = $393,933 )
2016	2016	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	440 WEST FRANKLIN ST, CB #1350	CHAPEL HILL	NC	27599	ORANGE	USA	Cancer Cause and Prevention Research	000	7	8/4/2016	NON-COMPETING CONTINUATION	$393,933
														Subtotal = $393,933

Issue Date FY: 2015 ( Subtotal = $406,933 )
2015	2015	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	440 WEST FRANKLIN ST, CB #1350	CHAPEL HILL	NC	27599	ORANGE	USA	Cancer Cause and Prevention Research	001	6	9/16/2015	COMPETING CONTINUATION	$406,933
2015	2014	BAYLOR COLLEGE OF MEDICINE	ONE BAYLOR PLAZA	HOUSTON	TX	77030	HARRIS	USA	Cancer Biology Research	000	5	9/11/2015	NON-COMPETING CONTINUATION	$0
														Subtotal = $406,933

Issue Date FY: 2014 ( Subtotal = $471,844 )
2014	2014	BAYLOR COLLEGE OF MEDICINE	ONE BAYLOR PLAZA	HOUSTON	TX	77030	HARRIS	USA	Cancer Biology Research	000	5	12/16/2013	NON-COMPETING CONTINUATION	$437,794
2014	2014	BAYLOR COLLEGE OF MEDICINE	ONE BAYLOR PLAZA	HOUSTON	TX	77030	HARRIS	USA	Cancer Biology Research	001	5	5/8/2014	NON-COMPETING CONTINUATION	$34,050
														Subtotal = $471,844

Issue Date FY: 2013 ( Subtotal = $459,677 )
2013	2013	BAYLOR COLLEGE OF MEDICINE	ONE BAYLOR PLAZA	HOUSTON	TX	77030	HARRIS	USA	Cancer Biology Research	001	4	6/5/2013	NON-COMPETING CONTINUATION	$215,168
2013	2013	BAYLOR COLLEGE OF MEDICINE	ONE BAYLOR PLAZA	HOUSTON	TX	77030	HARRIS	USA	Cancer Biology Research	000	4	12/10/2012	NON-COMPETING CONTINUATION	$244,509
														Subtotal = $459,677

Issue Date FY: 2012 ( Subtotal = $491,675 )
2012	2012	BAYLOR COLLEGE OF MEDICINE	ONE BAYLOR PLAZA	HOUSTON	TX	77030	HARRIS	USA	Cancer Biology Research	001	3	4/30/2012	NON-COMPETING CONTINUATION	$40,317
2012	2012	BAYLOR COLLEGE OF MEDICINE	ONE BAYLOR PLAZA	HOUSTON	TX	77030	HARRIS	USA	Cancer Biology Research	000	3	12/30/2011	NON-COMPETING CONTINUATION	$451,358
														Subtotal = $491,675

Issue Date FY: 2011 ( Subtotal = $494,417 )
2011	2011	BAYLOR COLLEGE OF MEDICINE	ONE BAYLOR PLAZA	HOUSTON	TX	77030	HARRIS	USA	Cancer Biology Research	001	2	5/18/2011	NON-COMPETING CONTINUATION	$21,918
2011	2011	BAYLOR COLLEGE OF MEDICINE	ONE BAYLOR PLAZA	HOUSTON	TX	77030	HARRIS	USA	Cancer Biology Research	000	2	12/30/2010	NON-COMPETING CONTINUATION	$472,499
														Subtotal = $494,417

Issue Date FY: 2010 ( Subtotal = $464,834 )
2010	2010	BAYLOR COLLEGE OF MEDICINE	ONE BAYLOR PLAZA	HOUSTON	TX	77030	HARRIS	USA	Cancer Biology Research	000	1	3/17/2010	NEW	$464,834
														Subtotal = $464,834

Grand Total All Awards = $6,423,854

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Therapeutic Targeting of Breast Cancer Tumor Initiating Cells

Award Number: R01CA148761

ORGANIZATION: NATIONAL CANCER INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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