Friday, June 27, 2025 6/27/2025

PROTEASE ACTIVATED RECEPTOR IN TUMOR BIOLOGY

Award Number: R01CA085405
ORGANIZATION: NATIONAL CANCER INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 01/11/2001
PERIOD OF PERFORMANCE END DATE: 11/30/2005

Group Awards By:

View Award Description

PROTEASE ACTIVATED RECEPTOR IN TUMOR BIOLOGY - DESCRIPTION: (Adapted from the investigator's abstract) Protease activated receptor-1 (PAR-1), also known as thrombin receptor, is an important cell surface receptor that in response to injury regulates diverse cellular functions. PAR-1 is expressed on activated vascular cells and on tumor cells. A role for PAR-1 in tumor biology is supported by the finding that the receptor is upregulated in the progression of breast cancer, but very little information is available on whether and how PAR-1 activity might influence the behavior of malignant tumors. To support the hypothesis that PAR-1 on vascular cells contributes to the generation of tumor neovessels, growth factor and tumor cell-induced angiogenesis, as well as tumor growth in PAR-1 deficient mice, will be compared to control mice. It will be determined which vascular cell types express PAR-1 and how PAR-1 activation influences vascular cell behavior in the growth and development of new vessels. To implicate PAR-1 as a mitogenic receptor for tumor cells, it will be tested whether PAR-1 activation on human breast cancer cells results in enhanced proliferation in vitro and tumor growth in the m.f.p. of SCID mice. Transformed cell lines from PAR-1 deficient mice will be transfected to express PAR-1 and studied for the effect of thrombin on cell growth in vitro and in s.c. tumors to implicate PAR-1 in tumor models where PAR-1 expression is genetically controlled. To investigate the contribution of PAR-1 to tumor cell invasion and metastasis, it will be tested whether PAR-1 activation in human breast carcinoma cell lines results in the expression of proteins associated with invasive behavior and in enhanced cell migration and invasion in vitro. It will be determine in SCID mice whether PAR-1 expression and activation on human breast carcinoma cells contributes to experimental and spontaneous metastasis and in transgenic MMTV-PymT mice whether PAR-1 is involved in mammary tumor development and progression. Finally, it will be addressed whether tumor cell generated thrombin is required for PAR-1 activation in the context of tumor metastasis. Together, these studies will critically assess the contribution of PAR-1 to tumor growth and dissemination and identify the mechanisms involved.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2004 ( Subtotal = $394,129 )
2004	2004	LA JOLLA INSTITUTE FOR MOLECULAR MEDICINE	4570 EXECUTIVE DR, SUITE 100	SAN DIEGO	CA	92121	SAN DIEGO	USA	Cancer Biology Research	000	5	12/1/2003	NON-COMPETING CONTINUATION	$394,129
														Subtotal = $394,129

Issue Date FY: 2003 ( Subtotal = $394,129 )
2003	2003	LA JOLLA INSTITUTE FOR MOLECULAR MEDICINE	4570 EXECUTIVE DR, SUITE 100	SAN DIEGO	CA	92121	SAN DIEGO	USA	Cancer Biology Research	000	4		NON-COMPETING CONTINUATION	$394,129
														Subtotal = $394,129

Issue Date FY: 2002 ( Subtotal = $394,129 )
2002	2002	LA JOLLA INSTITUTE FOR MOLECULAR MEDICINE	4570 EXECUTIVE DR, SUITE 100	SAN DIEGO	CA	92121	SAN DIEGO	USA	Cancer Biology Research	000	3	1/7/2002	NON-COMPETING CONTINUATION	$394,129
														Subtotal = $394,129

Issue Date FY: 2001 ( Subtotal = $373,407 )
2001	2001	LA JOLLA INSTITUTE FOR MOLECULAR MEDICINE	4570 EXECUTIVE DR, SUITE 100	SAN DIEGO	CA	92121	SAN DIEGO	USA	Cancer Biology Research	000	2	9/26/2001	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$250,937
2001	2001	SCRIPPS RESEARCH INSTITUTE, TPC 7	10666 NORTH TORREY PINES ROAD	LA JOLLA	CA	92037	SAN DIEGO	USA	Cancer Biology Research	000	1	9/26/2001	NEW	$122,470
														Subtotal = $373,407

Grand Total All Awards = $1,555,794

Top

All Categories

About

Search

Reports

Data Submission

Award Information

PROTEASE ACTIVATED RECEPTOR IN TUMOR BIOLOGY

Award Number: R01CA085405

ORGANIZATION: NATIONAL CANCER INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 01/11/2001

PERIOD OF PERFORMANCE END DATE: 11/30/2005

Federal Websites

Department of Health & Human Services

HHS Operating Divisions

HHS Staff Divisions

Download A Document Viewer