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RESPIRATORY CONTROL AND EMOTION REGULATION

Award Number: R01AT012412
ORGANIZATION: CENTER FOR DRUG EVALUATION AND RESEARCH, NIH
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/19/2022
PERIOD OF PERFORMANCE END DATE: 06/30/2025

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RESPIRATORY CONTROL AND EMOTION REGULATION - Over the past few decades, research involving the neural control of breathing has centered on how the breathing rhythm is generated and how sensory systems detect internal and external changes to modulate the breathing pattern. While we have learned that the regulatory breathing rhythm originates in the medulla, we know little about the neural circuits by which breathing affects emotional state. The positive effects of controlled breathing on emotional state have been observed across many contexts and in the clinic. Using objective behavioral, physiological, and neuroanatomical parameters, we propose: i) to fully determine the neural pathways in mice from the preBötzinger Complex, the key site generating inspiratory rhythm in the medulla, to supramedullary regions, in particular to the locus coeruleus and its ascending projections, that effect and/or affect emotional state, and; ii) to establish the role of these projections from the preBötzinger Complex in mediating the effects of breathing on anxiety, fear and panic in mice. The proposed research has the potential to lead to more effective methods for treating debilitating negative emotional states


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $0 )
2026	2024	UNIVERSITY OF CALIFORNIA, LOS ANGELES	10889 WILSHIRE BLVD STE 700	LOS ANGELES	CA	90024	LOS ANGELES	USA	Research and Training in Complementary and Integrative Health	000	3	3/2/2026	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2025 ( Subtotal = $741,000 )
2025	2025	UNIVERSITY OF CALIFORNIA, LOS ANGELES	10889 WILSHIRE BLVD STE 700	LOS ANGELES	CA	90024	LOS ANGELES	USA	Research and Training in Complementary and Integrative Health	000	4	8/4/2025	EXTENSION WITH OR WITHOUT FUNDS	$741,000
2025	2024	UNIVERSITY OF CALIFORNIA, LOS ANGELES	10889 WILSHIRE BLVD STE 700	LOS ANGELES	CA	90024	LOS ANGELES	USA	Research and Training in Complementary and Integrative Health	001	3	8/5/2025	NON-COMPETING CONTINUATION	$0
														Subtotal = $741,000

Issue Date FY: 2024 ( Subtotal = $382,200 )
2024	2024	UNIVERSITY OF CALIFORNIA, LOS ANGELES	10889 WILSHIRE BLVD STE 700	LOS ANGELES	CA	90024	LOS ANGELES	USA	Research and Training in Complementary and Integrative Health	000	3	7/1/2024	NON-COMPETING CONTINUATION	$382,200
														Subtotal = $382,200

Issue Date FY: 2023 ( Subtotal = $390,000 )
2023	2023	UNIVERSITY OF CALIFORNIA, LOS ANGELES	10889 WILSHIRE BLVD STE 700	LOS ANGELES	CA	90024	LOS ANGELES	USA	Research and Training in Complementary and Integrative Health	000	2	7/10/2023	NON-COMPETING CONTINUATION	$390,000
														Subtotal = $390,000

Issue Date FY: 2022 ( Subtotal = $390,000 )
2022	2022	UNIVERSITY OF CALIFORNIA, LOS ANGELES	10889 WILSHIRE BLVD STE 700	LOS ANGELES	CA	90024	LOS ANGELES	USA	Research and Training in Complementary and Integrative Health	000	1	9/19/2022	NEW	$390,000
														Subtotal = $390,000

Grand Total All Awards = $1,903,200

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RESPIRATORY CONTROL AND EMOTION REGULATION

Award Number: R01AT012412

ORGANIZATION: CENTER FOR DRUG EVALUATION AND RESEARCH, NIH

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/19/2022

PERIOD OF PERFORMANCE END DATE: 06/30/2025

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