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The Role of Sensory Neurons Innervating Internal Organs

Award Number: R01AT012051
ORGANIZATION: CENTER FOR DRUG EVALUATION AND RESEARCH, NIH
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 08/18/2022
PERIOD OF PERFORMANCE END DATE: 05/31/2025

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The Role of Sensory Neurons Innervating Internal Organs - Projection Summary Over the last decades, we have made tremendous advancements in understanding the role of somatosensory neurons in sensing exteroceptive signals including touch, temperature, and pain. However, somatosensory neurons also innervate internal organs, but we understand much less about the anatomy and physiology of these neurons. There is literature on the roles of interoceptive neurons in sensing lung stretch and blood pressure. These studies mainly focus on the Vagal Nodose ganglia that innervate many internal organs. However, dorsal root ganglia (DRG) neurons, in addition to innervating skin and muscle, also innervate disparate internal organs but have garnered much less focus. To begin to elucidate the structure and function of these sensory neurons, we focus on adipose-innervating DRG neurons. These neurons are an attractive starting point because very little is known about their form and function, but these neurons could potentially have a profound relationship with the autonomic nervous systems (for example, the sympathetic nervous system) and roles in whole-body physiology. Here, we show that fat depots are robustly innervated by DRG neurons. We have also collected important preliminary data molecularly defining the subset of DRGs that innervate fat depots, and have begun to address their interactions with the sympathetic activities. We propose to use state-of-the-art and innovative molecular and genetic techniques to map adipose-innervating DRG neurons, profile their identities, and test their function.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $1,159,743 )
2025	2025	SCRIPPS RESEARCH INSTITUTE	10550 N TORREY PINES RD	LA JOLLA	CA	92037	SAN DIEGO	USA	Research and Training in Complementary and Integrative Health	000	4	7/30/2025	EXTENSION WITH OR WITHOUT FUNDS	$1,159,743
2025	2024	SCRIPPS RESEARCH INSTITUTE	10550 N TORREY PINES RD	LA JOLLA	CA	92037	SAN DIEGO	USA	Research and Training in Complementary and Integrative Health	001	3	7/31/2025	NON-COMPETING CONTINUATION	$0
														Subtotal = $1,159,743

Issue Date FY: 2024 ( Subtotal = $598,182 )
2024	2024	SCRIPPS RESEARCH INSTITUTE	10550 N TORREY PINES RD	LA JOLLA	CA	92037	SAN DIEGO	USA	Research and Training in Complementary and Integrative Health	000	3	5/29/2024	NON-COMPETING CONTINUATION	$598,182
														Subtotal = $598,182

Issue Date FY: 2023 ( Subtotal = $600,439 )
2023	2023	SCRIPPS RESEARCH INSTITUTE, THE	10550 NORTH TORREY PINES RD	LA JOLLA	CA	92037	SAN DIEGO	USA	Research and Training in Complementary and Integrative Health	000	2	5/23/2023	NON-COMPETING CONTINUATION	$600,439
														Subtotal = $600,439

Issue Date FY: 2022 ( Subtotal = $588,828 )
2022	2022	SCRIPPS RESEARCH INSTITUTE, THE	10550 NORTH TORREY PINES RD	LA JOLLA	CA	92037	SAN DIEGO	USA	Research and Training in Complementary and Integrative Health	001	1	9/1/2022	NEW	$0
2022	2022	SCRIPPS RESEARCH INSTITUTE, THE	10550 NORTH TORREY PINES RD	LA JOLLA	CA	92037	SAN DIEGO	USA	Research and Training in Complementary and Integrative Health	000	1	8/17/2022	NEW	$588,828
														Subtotal = $588,828

Grand Total All Awards = $2,947,192

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The Role of Sensory Neurons Innervating Internal Organs

Award Number: R01AT012051

ORGANIZATION: CENTER FOR DRUG EVALUATION AND RESEARCH, NIH

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 08/18/2022

PERIOD OF PERFORMANCE END DATE: 05/31/2025

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