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Redefining the Lifelong Natural History of Hip Osteoarthritis in Patients with Morphologic Abnormalities

Award Number: R01AR088008
ORGANIZATION: NATIONAL INSTITUTE OF ARTHRITIS & MUSCULOSKELETAL & SKIN DISEASES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/15/2026
PERIOD OF PERFORMANCE END DATE: 08/31/2031

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Redefining the Lifelong Natural History of Hip Osteoarthritis in Patients with Morphologic Abnormalities - ABSTRACT In the integrated mechanical concept of hip osteoarthritis (OA), subtle morphological abnormalities alter the natural biomechanics of the joint, eventually leading to OA and arthroplasty. Early screening of a specific morphological abnormality in European countries, developmental dysplasia of the hip (DDH) in infants, and subsequent intervention, has led to dwindling rates of early-onset OA and arthroplasty. Morphology remains the only suspected modifiable risk factor for OA - so understanding it fully is crucial. The proposed research will provide a mechanistic basis for morphological screening, by approaching the relationship between morphology and OA progression in three distinct aspects. First, in Aim 1 we will investigate the role of genetics in the formation of hip morphology phenotypes and their subsequent effect on the progression to OA by performing an analysis of whole exome sequencing data in two large genetic databases available at Mayo Clinic. In Aim 2, we plan to analyze the impact of morphological abnormalities and other clinical covariates on radiographic joint degeneration through sophisticated deep learning models applied to patient radiographs. We will address sparse imaging timelines with generative AI, allowing for much larger cohorts with significantly more radiographic data than has been possible. Finally, Aim 3 will investigate the impact of preventative interventions by performing an emulated target trial using. Such interventions could range from bracing to arthroscopy and osteotomies, with the potential to significantly alter the disease trajectory. Use of emulated trial techniques will allow for the integration of several long-term study populations to provide substantial evidence of the benefit of hip preservation procedures. By providing the mechanistic foundation for early screening and tailored intervention strategies, our findings aim to reduce the lifetime burden of hip disease, decrease the necessity for invasive treatments like total hip arthroplasty, and improve the quality of life for millions affected by this condition.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $607,990 )
2026	2026	MAYO CLINIC	200 1ST ST SW	ROCHESTER	MN	55905	OLMSTED	USA	Arthritis, Musculoskeletal and Skin Diseases Research	000	1	9/14/2026	NEW	$607,990
														Subtotal = $607,990

Grand Total All Awards = $607,990

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Redefining the Lifelong Natural History of Hip Osteoarthritis in Patients with Morphologic Abnormalities

Award Number: R01AR088008

ORGANIZATION: NATIONAL INSTITUTE OF ARTHRITIS & MUSCULOSKELETAL & SKIN DISEASES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/15/2026

PERIOD OF PERFORMANCE END DATE: 08/31/2031

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