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A Randomized, Double-Blind, Controlled, Multi-Center Trial of Colchicine in Calcium Pyrophosphate Deposition Disease

Award Number: R01AR084712
ORGANIZATION: NATIONAL INSTITUTE OF ARTHRITIS & MUSCULOSKELETAL & SKIN DISEASES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 08/10/2025
PERIOD OF PERFORMANCE END DATE: 07/31/2030

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A Randomized, Double-Blind, Controlled, Multi-Center Trial of Colchicine in Calcium Pyrophosphate Deposition Disease - PROJECT SUMMARY/ABSTRACT Calcium pyrophosphate deposition disease (CPPD) is a painful inflammatory crystalline arthritis that afflicts 8-10 million Americans, but targeted treatments do not currently exist and there are very few studies on this common arthritis. Some patients with CPPD report improved joint symptoms with long-term colchicine 0.6mg daily (FDA-approved dose for gout), though we currently lack tools to predict which CPPD patients will benefit. The NLRP3 inflammasome plays a key role in the pathophysiology of CPPD and cardiovascular (CV) disease, and CV risk is up to two-fold higher in patients with CPPD than matched comparators. Understanding colchicine's impact on the NLRP3 inflammasome and downstream pathways will provide critical knowledge about mechanisms by which colchicine reduces CPPD symptoms and has tremendous


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $777,869 )
2025	2025	BRIGHAM & WOMENS HOSPITAL INC	75 FRANCIS ST	BOSTON	MA	02115	SUFFOLK	USA	Arthritis, Musculoskeletal and Skin Diseases Research	000	1	7/31/2025	NEW	$777,869
														Subtotal = $777,869

Grand Total All Awards = $777,869

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A Randomized, Double-Blind, Controlled, Multi-Center Trial of Colchicine in Calcium Pyrophosphate Deposition Disease

Award Number: R01AR084712

ORGANIZATION: NATIONAL INSTITUTE OF ARTHRITIS & MUSCULOSKELETAL & SKIN DISEASES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 08/10/2025

PERIOD OF PERFORMANCE END DATE: 07/31/2030

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