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Molecular control of blood vessel types at the regenerative interface for engineering of osteogenic and angiogenic periosteum mimetic

Award Number: R01AR083224
ORGANIZATION: NATIONAL INSTITUTE OF ARTHRITIS & MUSCULOSKELETAL & SKIN DISEASES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 08/02/2023
PERIOD OF PERFORMANCE END DATE: 01/31/2029

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Molecular control of blood vessel types at the regenerative interface for engineering of osteogenic and angiogenic periosteum mimetic - Abstract Autograft is considered the gold standard for large bone defect repair and reconstruction. The superior healing potential of autografts is attributed to the robust osteogenic and angiogenic activities of periosteum– a highly vascularized thin tissue membrane covering the outer surface of bone. To recapitulate the superior healing potential of periosteum, a series of tissue engineering strategies have been developed, aiming to construct a biomimetic tissue-engineered periosteum (TEP) for enhanced bone defect repair and reconstruction. The success of these strategies hinges on a thorough understanding of the osteogenic and angiogenic role of periosteum and a better insight into the intricate relationship between bone and vessel forming cells at the regenerative interface of periosteum-mediated repair. Supported by NIH funding, we have made a series of progresses in construction of a biomimetic functional periosteum and in understanding of the functional vascular bed at the site of periosteal repair utilizing transgenic animals that label subtypes of endothelial cells. Building on these progresses, the proposed work will focus on understanding the molecular control of periosteum-mediated bone-specialized vessel formation, with further efforts devoted to building a technological platform for controlled delivery of angiogenic and osteogenic factors for reconstruction of a pro- angiogenic and pro-osteogenic periosteum mimetic for augmented bone allograft repair. The completion of the proposed study will provide new insights into the molecular control of bone-specialized blood vessel formation during periosteum-mediated repair, further offering engineering-based strategies targeting osteogenic and angiogenic interface for augmented defect repair at a compromised periosteal site.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $495,828 )
2026	2026	UNIVERSITY OF ROCHESTER	910 GENESEE ST	ROCHESTER	NY	14611	MONROE	USA	Arthritis, Musculoskeletal and Skin Diseases Research	000	3	1/21/2026	NON-COMPETING CONTINUATION	$495,828
														Subtotal = $495,828

Issue Date FY: 2025 ( Subtotal = $0 )
2025	2024	UNIVERSITY OF ROCHESTER	910 GENESEE ST	ROCHESTER	NY	14611	MONROE	USA	Arthritis, Musculoskeletal and Skin Diseases Research	000	2	6/27/2025	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2024 ( Subtotal = $494,149 )
2024	2024	UNIVERSITY OF ROCHESTER	910 GENESEE ST	ROCHESTER	NY	14611	MONROE	USA	Arthritis, Musculoskeletal and Skin Diseases Research	000	2	7/16/2024	NON-COMPETING CONTINUATION	$494,149
														Subtotal = $494,149

Issue Date FY: 2023 ( Subtotal = $558,888 )
2023	2023	UNIVERSITY OF ROCHESTER	910 GENESEE ST	ROCHESTER	NY	14611	MONROE	USA	Arthritis, Musculoskeletal and Skin Diseases Research	000	1	8/2/2023	NEW	$558,888
														Subtotal = $558,888

Grand Total All Awards = $1,548,865

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Molecular control of blood vessel types at the regenerative interface for engineering of osteogenic and angiogenic periosteum mimetic

Award Number: R01AR083224

ORGANIZATION: NATIONAL INSTITUTE OF ARTHRITIS & MUSCULOSKELETAL & SKIN DISEASES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 08/02/2023

PERIOD OF PERFORMANCE END DATE: 01/31/2029

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