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Establishing The Validity, Responsiveness, And Appropriateness Of Patient-Reported Outcome Measures For Adult Traumatic Brachial Plexus Injury

Award Number: R01AR079139
ORGANIZATION: NATIONAL INSTITUTE OF ARTHRITIS & MUSCULOSKELETAL & SKIN DISEASES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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Establishing The Validity, Responsiveness, And Appropriateness Of Patient-Reported Outcome Measures For Adult Traumatic Brachial Plexus Injury - PROJECT SUMMARY/ABSTRACT Adult traumatic brachial plexus injuries (BPI) have a devastating impact on patients, affecting multiple domains (physical, social, and emotional) of their lives. Prior studies have focused on neurologic and biologic predictors of severity of injury (such as extent of plexus injury), but little attention has been paid to other predictors of recovery. A better understanding of how other factors (such as emotional trauma, mental health, pain, and social support) influence recovery after BPI will provide new insight into ways to optimize outcomes for BPI patients. The long-term goal of our research program is to develop a national multicenter prospective cohort study of patients with BPI, assessing outcomes at standardized intervals using a patient-reported, disease-specific outcome measure that captures the physical and emotional domains of recovery. The objectives of this application are (1) to determine the outcome measures that best capture the experience of recovering from BPI and (2) to establish a framework of prospective multicenter data collection that can be expanded in the near future. We will use a prospective observational cohort study design, enrolling patients from five centers prior to surgical reconstruction for adult traumatic BPI. We will examine the criterion validity, responsiveness, and appropriateness of the DASH, SF-36, and a BPI-specific, patient-reported outcomes instrument that our group recently developed (“Impact of BPI” questionnaire). After we have completed the expected research, we will have a well-validated outcome measure for the BPI population along with the ability to define which surgical treatments provide meaningful improvement to patients.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $0 )
2025	2023	WASHINGTON UNIVERSITY, THE	1 BROOKINGS DR	SAINT LOUIS	MO	63130	SAINT LOUIS	USA	Arthritis, Musculoskeletal and Skin Diseases Research	000	3	3/13/2025	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2023 ( Subtotal = $184,464 )
2023	2023	WASHINGTON UNIVERSITY, THE	ONE BROOKINGS DR	SAINT LOUIS	MO	63130	SAINT LOUIS	USA	Arthritis, Musculoskeletal and Skin Diseases Research	000	3	3/15/2023	NON-COMPETING CONTINUATION	$184,464
														Subtotal = $184,464

Issue Date FY: 2022 ( Subtotal = $216,922 )
2022	2022	WASHINGTON UNIVERSITY, THE	ONE BROOKINGS DR	SAINT LOUIS	MO	63130	SAINT LOUIS	USA	Arthritis, Musculoskeletal and Skin Diseases Research	000	2	4/26/2022	NON-COMPETING CONTINUATION	$216,922
														Subtotal = $216,922

Issue Date FY: 2021 ( Subtotal = $254,388 )
2021	2021	WASHINGTON UNIVERSITY, THE	ONE BROOKINGS DR	SAINT LOUIS	MO	63130	SAINT LOUIS	USA	Arthritis, Musculoskeletal and Skin Diseases Research	000	1	4/2/2021	NEW	$254,388
														Subtotal = $254,388

Grand Total All Awards = $655,774

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Establishing The Validity, Responsiveness, And Appropriateness Of Patient-Reported Outcome Measures For Adult Traumatic Brachial Plexus Injury

Award Number: R01AR079139

ORGANIZATION: NATIONAL INSTITUTE OF ARTHRITIS & MUSCULOSKELETAL & SKIN DISEASES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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