Sunday, November 24, 2024 11/24/2024

Skin Stem Cells and Their Niche Interactions

Award Number: R01AR050452
ORGANIZATION: NATIONAL INSTITUTE OF ARTHRITIS & MUSCULOSKELETAL & SKIN DISEASES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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Project Summary/Abstract The global objective of this research is to elucidate the mechanisms underlying tissue homeostasis and regeneration in mammalian skin and to understand how this process goes awry in human disorders, including cancers. Central to achieving this goal is the characterization of the different stem cells (SCs) within skin, determining their relative contributions to tissue homeostasis and wound-repair, and elucidating how changes in their niche microenvironments impact these events. Past AR050452 research led to purification of hair follicle (HF) bulge and basal inter-follicular epidermal (Epd) cells and established them as long-lived, self-renewing SCs that function in tissue regeneration and wound-repair. However, both in their biology and their tissue regenerative tasks, these SCs display distinct behaviors predicated by their unique microenvironments (niches). The field still lacks a comprehensive knowledge of the constituents of these niches, the nature of SC:niche interactions, and how they help SCs cope with stressful situations. Past AR050452 research set the foundations to tackle the next key questions: (1). What are dynamics in bulge niche components that drive HFSC behavior during the hair cycle? (2) What are the key niche:HFSC interactions that maintain quiescence and drive tissue (hair) regeneration and how do they differ from the niche: short-lived progeny interactions that drive hair differentiation? (3) How are HFSCs spared during the destructive phase of the cycle when hair growth ceases and most follicle cells below the bulge apoptose? Does eating confer increased SC fitness? (4) How do HFSC:niche interactions change when skin is injured and the SCs become repurposed to repair the wound? How do SCs protect themselves against immune/pathogen attack so that they can orchestrate the re-epithelialization process? (5) How does the natural process of wound-repair differ from the behavior of a SC when it acquires an oncogenic mutation that will ultimately lead it down a path to cancer? To answer these questions, we'll use FACS, single cell spatial transcriptomics and chromatin landscaping, conditional gene knockout and RNAi screens in vivo and employ these methods to explore skin stem cells in their native, wound-induced and tumorigenic environments.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = $410,337 )
2024	2024	ROCKEFELLER UNIVERSITY	1230 YORK AVE	NEW YORK	NY	10065	NEW YORK	USA	Arthritis, Musculoskeletal and Skin Diseases Research	000	21	5/10/2024	COMPETING CONTINUATION	$410,337
														Subtotal = $410,337

Issue Date FY: 2023 ( Subtotal = $372,900 )
2023	2023	ROCKEFELLER UNIVERSITY	1230 YORK AVE	NEW YORK	NY	10065	NEW YORK	USA	Arthritis, Musculoskeletal and Skin Diseases Research	000	20	4/27/2023	NON-COMPETING CONTINUATION	$372,900
														Subtotal = $372,900

Issue Date FY: 2022 ( Subtotal = $369,171 )
2022	2022	ROCKEFELLER UNIVERSITY	1230 YORK AVE	NEW YORK	NY	10065	NEW YORK	USA	Arthritis, Musculoskeletal and Skin Diseases Research	000	19	5/4/2022	NON-COMPETING CONTINUATION	$369,171
														Subtotal = $369,171

Issue Date FY: 2021 ( Subtotal = $361,712 )
2021	2021	ROCKEFELLER UNIVERSITY, THE	1230 YORK AVE	NEW YORK	NY	10065	NEW YORK	USA	Arthritis, Musculoskeletal and Skin Diseases Research	000	18	5/19/2021	NON-COMPETING CONTINUATION	$361,712
														Subtotal = $361,712

Issue Date FY: 2020 ( Subtotal = $372,900 )
2020	2020	ROCKEFELLER UNIVERSITY, THE	1230 YORK AVE	NEW YORK	NY	10065	NEW YORK	USA	Arthritis, Musculoskeletal and Skin Diseases Research	002	17	4/17/2020	NON-COMPETING CONTINUATION	$372,900
2020	2019	ROCKEFELLER UNIVERSITY, THE	1230 YORK AVE	NEW YORK	NY	10065	NEW YORK	USA	Arthritis, Musculoskeletal and Skin Diseases Research	001	16	12/3/2019	COMPETING CONTINUATION	$131
2020	2018	ROCKEFELLER UNIVERSITY, THE	1230 YORK AVE	NEW YORK	NY	10065	NEW YORK	USA	Arthritis, Musculoskeletal and Skin Diseases Research	000	15	12/3/2019	NON-COMPETING CONTINUATION	-$131
														Subtotal = $372,900

Issue Date FY: 2019 ( Subtotal = $372,900 )
2019	2019	ROCKEFELLER UNIVERSITY, THE	1230 YORK AVE	NEW YORK	NY	10065	NEW YORK	USA	Arthritis, Musculoskeletal and Skin Diseases Research	002	16	9/3/2019	COMPETING CONTINUATION	$874
2019	2019	ROCKEFELLER UNIVERSITY, THE	1230 YORK AVE	NEW YORK	NY	10065	NEW YORK	USA	Arthritis, Musculoskeletal and Skin Diseases Research	000	16	4/30/2019	COMPETING CONTINUATION	$372,900
2019	2018	ROCKEFELLER UNIVERSITY, THE	1230 YORK AVE	NEW YORK	NY	10065	NEW YORK	USA	Arthritis, Musculoskeletal and Skin Diseases Research	001	15	9/3/2019	NON-COMPETING CONTINUATION	-$874
														Subtotal = $372,900

Issue Date FY: 2018 ( Subtotal = $372,900 )
2018	2018	ROCKEFELLER UNIVERSITY, THE	1230 YORK AVE	NEW YORK	NY	10065	NEW YORK	USA	Arthritis, Musculoskeletal and Skin Diseases Research	000	15	5/8/2018	NON-COMPETING CONTINUATION	$372,900
														Subtotal = $372,900

Issue Date FY: 2017 ( Subtotal = $372,900 )
2017	2017	ROCKEFELLER UNIVERSITY, THE	1230 YORK AVE	NEW YORK	NY	10065	NEW YORK	USA	Arthritis, Musculoskeletal and Skin Diseases Research	001	14	6/14/2017	NON-COMPETING CONTINUATION	$37,290
2017	2017	ROCKEFELLER UNIVERSITY, THE	1230 YORK AVE	NEW YORK	NY	10065	NEW YORK	USA	Arthritis, Musculoskeletal and Skin Diseases Research	000	14	4/28/2017	NON-COMPETING CONTINUATION	$335,610
														Subtotal = $372,900

Issue Date FY: 2016 ( Subtotal = $372,900 )
2016	2016	ROCKEFELLER UNIVERSITY	EAST 66TH STREET & YORK AVENUE	NEW YORK	NY	10021	NEW YORK	USA	Arthritis, Musculoskeletal and Skin Diseases Research	000	13	4/7/2016	NON-COMPETING CONTINUATION	$372,900
														Subtotal = $372,900

Issue Date FY: 2015 ( Subtotal = $372,900 )
2015	2015	ROCKEFELLER UNIVERSITY	EAST 66TH STREET & YORK AVENUE	NEW YORK	NY	10021	NEW YORK	USA	Arthritis, Musculoskeletal and Skin Diseases Research	000	12	4/3/2015	NON-COMPETING CONTINUATION	$372,900
														Subtotal = $372,900

Issue Date FY: 2014 ( Subtotal = $372,900 )
2014	2014	ROCKEFELLER UNIVERSITY	EAST 66TH STREET & YORK AVENUE	NEW YORK	NY	10021	NEW YORK	USA	Arthritis, Musculoskeletal and Skin Diseases Research	000	11	3/26/2014	COMPETING CONTINUATION	$372,900
														Subtotal = $372,900

Issue Date FY: 2013 ( Subtotal = $343,320 )
2013	2013	ROCKEFELLER UNIVERSITY	EAST 66TH STREET & YORK AVENUE	NEW YORK	NY	10021	NEW YORK	USA	Arthritis, Musculoskeletal and Skin Diseases Research	001	10	7/15/2013	NON-COMPETING CONTINUATION	$18,069
2013	2013	ROCKEFELLER UNIVERSITY	EAST 66TH STREET & YORK AVENUE	NEW YORK	NY	10021	NEW YORK	USA	Arthritis, Musculoskeletal and Skin Diseases Research	000	10	4/19/2013	NON-COMPETING CONTINUATION	$325,251
														Subtotal = $343,320

Issue Date FY: 2012 ( Subtotal = $361,390 )
2012	2012	ROCKEFELLER UNIVERSITY	EAST 66TH STREET & YORK AVENUE	NEW YORK	NY	10021	NEW YORK	USA	Arthritis, Musculoskeletal and Skin Diseases Research	000	9	4/20/2012	NON-COMPETING CONTINUATION	$361,390
														Subtotal = $361,390

Issue Date FY: 2011 ( Subtotal = $361,390 )
2011	2011	ROCKEFELLER UNIVERSITY	EAST 66TH STREET & YORK AVENUE	NEW YORK	NY	10021	NEW YORK	USA	Arthritis, Musculoskeletal and Skin Diseases Research	001	8	6/8/2011	NON-COMPETING CONTINUATION	$22,587
2011	2011	ROCKEFELLER UNIVERSITY	EAST 66TH STREET & YORK AVENUE	NEW YORK	NY	10021	NEW YORK	USA	Arthritis, Musculoskeletal and Skin Diseases Research	000	8	4/13/2011	NON-COMPETING CONTINUATION	$338,803
														Subtotal = $361,390

Issue Date FY: 2010 ( Subtotal = $376,448 )
2010	2010	ROCKEFELLER UNIVERSITY	EAST 66TH STREET & YORK AVENUE	NEW YORK	NY	10021	NEW YORK	USA	Arthritis, Musculoskeletal and Skin Diseases Research	000	7	4/28/2010	NON-COMPETING CONTINUATION	$376,448
														Subtotal = $376,448

Issue Date FY: 2009 ( Subtotal = $380,250 )
2009	2009	ROCKEFELLER UNIVERSITY	EAST 66TH STREET & YORK AVENUE	NEW YORK	NY	10021	NEW YORK	USA	Arthritis, Musculoskeletal and Skin Diseases Research	001	6	6/17/2009	COMPETING CONTINUATION	$380,250
2009	2008	ROCKEFELLER UNIVERSITY	EAST 66TH STREET & YORK AVENUE	NEW YORK	NY	10021	NEW YORK	USA	Arthritis, Musculoskeletal and Skin Diseases Research	000	5	6/17/2009	NON-COMPETING CONTINUATION	$0
														Subtotal = $380,250

Issue Date FY: 2008 ( Subtotal = $372,107 )
2008	2008	ROCKEFELLER UNIVERSITY	EAST 66TH STREET & YORK AVENUE	NEW YORK	NY	10021	NEW YORK	USA	Arthritis, Musculoskeletal and Skin Diseases Research	000	5	2/6/2008	NON-COMPETING CONTINUATION	$372,107
														Subtotal = $372,107

Issue Date FY: 2007 ( Subtotal = $368,643 )
2007	2007	ROCKEFELLER UNIVERSITY	EAST 66TH STREET & YORK AVENUE	NEW YORK	NY	10021	NEW YORK	USA	Arthritis, Musculoskeletal and Skin Diseases Research	000	4	1/31/2007	NON-COMPETING CONTINUATION	$368,643
														Subtotal = $368,643

Issue Date FY: 2006 ( Subtotal = $368,594 )
2006	2006	ROCKEFELLER UNIVERSITY	EAST 66TH STREET & YORK AVENUE	NEW YORK	NY	10021	NEW YORK	USA	Arthritis, Musculoskeletal and Skin Diseases Research	000	3	1/31/2006	NON-COMPETING CONTINUATION	$368,594
														Subtotal = $368,594

Issue Date FY: 2005 ( Subtotal = $366,473 )
2005	2005	ROCKEFELLER UNIVERSITY	EAST 66TH STREET & YORK AVENUE	NEW YORK	NY	10021	NEW YORK	USA	Arthritis, Musculoskeletal and Skin Diseases Research	000	2	11/26/2004	NON-COMPETING CONTINUATION	$366,473
														Subtotal = $366,473

Issue Date FY: 2004 ( Subtotal = $355,625 )
2004	2004	ROCKEFELLER UNIVERSITY	EAST 66TH STREET & YORK AVENUE	NEW YORK	NY	10021	NEW YORK	USA	Arthritis, Musculoskeletal and Skin Diseases Research	000	1	2/26/2004	NEW	$355,625
														Subtotal = $355,625

Grand Total All Awards = $7,778,660

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Skin Stem Cells and Their Niche Interactions

Award Number: R01AR050452

ORGANIZATION: NATIONAL INSTITUTE OF ARTHRITIS & MUSCULOSKELETAL & SKIN DISEASES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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