Official websites use .gov

A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS

A lock ( 🔒 ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

Need Help

Regulation of Epidermal Development and Differentiation

Award Number: R01AR031737
ORGANIZATION: NATIONAL INSTITUTE OF ARTHRITIS & MUSCULOSKELETAL & SKIN DISEASES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 01/01/1983
PERIOD OF PERFORMANCE END DATE: 04/30/2031

Group Awards By:

View Award Description

Regulation of Epidermal Development and Differentiation - Project Summary/Abstract Our global objective is to elucidate the molecular mechanisms underlying tissue homeostasis and regeneration in mammalian skin epithelium and how this process goes awry in inflammation and malignancy, with the ultimate aspiration of advancing treatments of chronic inflammatory disorders and cancers. Central to achieving this goal is to determine how the stem cells that make the skin's epidermis and appendages (hair follicles, sweat and sebaceous glands) sense and tailor their programs of gene expression in order to perform their particular tasks during homeostasis and wound repair and survive under stressful situations. Our past AR31737 research revealed that while these tissue stem cells originate from a common embryonic skin progenitor, they reside in different microenvironments in adult skin, bestowing them with distinct molecular properties and tailored instructions to perform separate tasks. As we unraveled the chromatin dynamics that govern skin stem cell behavior during normal homeostasis, we began exploring how stem cells cope with changes to their environment that emanate from inflammation and tissue injury. We discovered that remarkably and independently of B or T lymphocytes or macrophages, the stem cells acquire and retain long-lasting epigenetic memories of these experiences, endowing the epidermis to respond quicker and more broadly to future secondary assaults. Focusing on a psoriasis-like (Th17) inflammatory response, we identified transcription factors and histone modifications that underly establishment, maintenance and recall of epidermal stem cell memory, yielding insights into many hitherto puzzling features of human chronic inflammatory disease. In 2026-31, we'll now address: Is this inflammatory memory exclusive to and homogeneous across epidermal stem cells whether quiescent or proliferating and whether in unique niches, e.g. hair follicle orifice or interfollicular epidermis? Can memory be retained across cell divisions and if so how? How do memories change upon different kinds of experiences? Do skin stem cells acquire memories of early life events, e.g. the hypoxic experience in the mammalian womb, and if so, does this better prepare the tissue for postnatal hypoxic encounters, e.g. wounds? Finally, while beneficial for wound repair and tissue fitness, do epigenetic memories heighten susceptibility to disease states, most notably chronic inflammation and cancer? By coupling in vivo high throughput technologies with molecular, cell and developmental biology and functional interrogations, we aim to advance our knowledge of tissue fitness, wound repair, inflammatory disorders and malignancies and provide major new insights to therapeutic strategies.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $592,680 )
2026	2026	ROCKEFELLER UNIVERSITY	1230 YORK AVE	NEW YORK	NY	10065	NEW YORK	USA	Arthritis, Musculoskeletal and Skin Diseases Research	000	44	6/8/2026	COMPETING CONTINUATION	$592,680
														Subtotal = $592,680

Issue Date FY: 2025 ( Subtotal = $593,412 )
2025	2025	ROCKEFELLER UNIVERSITY	1230 YORK AVE	NEW YORK	NY	10065	NEW YORK	USA	Arthritis, Musculoskeletal and Skin Diseases Research	000	43	7/23/2025	NON-COMPETING CONTINUATION	$593,412
														Subtotal = $593,412

Issue Date FY: 2024 ( Subtotal = $639,565 )
2024	2024	ROCKEFELLER UNIVERSITY	1230 YORK AVE	NEW YORK	NY	10065	NEW YORK	USA	Arthritis, Musculoskeletal and Skin Diseases Research	000	42	5/9/2024	NON-COMPETING CONTINUATION	$639,565
														Subtotal = $639,565

Issue Date FY: 2023 ( Subtotal = $659,345 )
2023	2023	ROCKEFELLER UNIVERSITY	1230 YORK AVE	NEW YORK	NY	10065	NEW YORK	USA	Arthritis, Musculoskeletal and Skin Diseases Research	000	41	5/10/2023	NON-COMPETING CONTINUATION	$659,345
														Subtotal = $659,345

Issue Date FY: 2022 ( Subtotal = $652,753 )
2022	2022	ROCKEFELLER UNIVERSITY	1230 YORK AVE	NEW YORK	NY	10065	NEW YORK	USA	Arthritis, Musculoskeletal and Skin Diseases Research	002	40	6/14/2022	NON-COMPETING CONTINUATION	$652,753
2022	2021	ROCKEFELLER UNIVERSITY	1230 YORK AVE	NEW YORK	NY	10065	NEW YORK	USA	Arthritis, Musculoskeletal and Skin Diseases Research	001	39	10/23/2021	COMPETING CONTINUATION	$5,001
2022	2020	ROCKEFELLER UNIVERSITY	1230 YORK AVE	NEW YORK	NY	10065	NEW YORK	USA	Arthritis, Musculoskeletal and Skin Diseases Research	000	38	10/23/2021	NON-COMPETING CONTINUATION	-$5,001
														Subtotal = $652,753

Issue Date FY: 2021 ( Subtotal = $659,345 )
2021	2021	ROCKEFELLER UNIVERSITY, THE	1230 YORK AVE	NEW YORK	NY	10065	NEW YORK	USA	Arthritis, Musculoskeletal and Skin Diseases Research	001	39	6/24/2021	COMPETING CONTINUATION	$659,345
2021	2020	ROCKEFELLER UNIVERSITY, THE	1230 YORK AVE	NEW YORK	NY	10065	NEW YORK	USA	Arthritis, Musculoskeletal and Skin Diseases Research	000	38	6/16/2021	NON-COMPETING CONTINUATION	$0
														Subtotal = $659,345

Issue Date FY: 2020 ( Subtotal = $563,882 )
2020	2020	ROCKEFELLER UNIVERSITY, THE	1230 YORK AVE	NEW YORK	NY	10065	NEW YORK	USA	Arthritis, Musculoskeletal and Skin Diseases Research	000	38	5/21/2020	NON-COMPETING CONTINUATION	$563,882
														Subtotal = $563,882

Issue Date FY: 2019 ( Subtotal = $563,882 )
2019	2019	ROCKEFELLER UNIVERSITY, THE	1230 YORK AVE	NEW YORK	NY	10065	NEW YORK	USA	Arthritis, Musculoskeletal and Skin Diseases Research	000	37	6/26/2019	NON-COMPETING CONTINUATION	$563,882
														Subtotal = $563,882

Issue Date FY: 2018 ( Subtotal = $563,882 )
2018	2018	ROCKEFELLER UNIVERSITY, THE	1230 YORK AVE	NEW YORK	NY	10065	NEW YORK	USA	Arthritis, Musculoskeletal and Skin Diseases Research	000	36	6/14/2018	NON-COMPETING CONTINUATION	$563,882
														Subtotal = $563,882

Issue Date FY: 2017 ( Subtotal = $563,882 )
2017	2017	ROCKEFELLER UNIVERSITY, THE	1230 YORK AVE	NEW YORK	NY	10065	NEW YORK	USA	Arthritis, Musculoskeletal and Skin Diseases Research	001	35	6/2/2017	NON-COMPETING CONTINUATION	$563,882
2017	2015	ROCKEFELLER UNIVERSITY, THE	1230 YORK AVE	NEW YORK	NY	10065	NEW YORK	USA	Arthritis, Musculoskeletal and Skin Diseases Research	000	33	11/9/2016	NON-COMPETING CONTINUATION	$0
														Subtotal = $563,882

Issue Date FY: 2016 ( Subtotal = $563,882 )
2016	2016	ROCKEFELLER UNIVERSITY	EAST 66TH STREET & YORK AVENUE	NEW YORK	NY	10021	NEW YORK	USA	Arthritis, Musculoskeletal and Skin Diseases Research	000	34	5/2/2016	COMPETING CONTINUATION	$563,882
														Subtotal = $563,882

Issue Date FY: 2015 ( Subtotal = $615,828 )
2015	2015	ROCKEFELLER UNIVERSITY	EAST 66TH STREET & YORK AVENUE	NEW YORK	NY	10021	NEW YORK	USA	Arthritis, Musculoskeletal and Skin Diseases Research	000	33	4/29/2015	NON-COMPETING CONTINUATION	$615,828
														Subtotal = $615,828

Issue Date FY: 2014 ( Subtotal = $597,658 )
2014	2014	ROCKEFELLER UNIVERSITY	EAST 66TH STREET & YORK AVENUE	NEW YORK	NY	10021	NEW YORK	USA	Arthritis, Musculoskeletal and Skin Diseases Research	000	32	5/16/2014	NON-COMPETING CONTINUATION	$597,658
														Subtotal = $597,658

Issue Date FY: 2013 ( Subtotal = $573,687 )
2013	2013	ROCKEFELLER UNIVERSITY	EAST 66TH STREET & YORK AVENUE	NEW YORK	NY	10021	NEW YORK	USA	Arthritis, Musculoskeletal and Skin Diseases Research	000	31	5/17/2013	NON-COMPETING CONTINUATION	$573,687
														Subtotal = $573,687

Issue Date FY: 2012 ( Subtotal = $597,445 )
2012	2012	ROCKEFELLER UNIVERSITY	EAST 66TH STREET & YORK AVENUE	NEW YORK	NY	10021	NEW YORK	USA	Arthritis, Musculoskeletal and Skin Diseases Research	000	30	5/18/2012	NON-COMPETING CONTINUATION	$597,445
														Subtotal = $597,445

Issue Date FY: 2011 ( Subtotal = $590,995 )
2011	2011	ROCKEFELLER UNIVERSITY	EAST 66TH STREET & YORK AVENUE	NEW YORK	NY	10021	NEW YORK	USA	Arthritis, Musculoskeletal and Skin Diseases Research	000	29	2/11/2011	COMPETING CONTINUATION	$590,995
														Subtotal = $590,995

Issue Date FY: 2010 ( Subtotal = $616,724 )
2010	2010	ROCKEFELLER UNIVERSITY	EAST 66TH STREET & YORK AVENUE	NEW YORK	NY	10021	NEW YORK	USA	Arthritis, Musculoskeletal and Skin Diseases Research	000	28	5/19/2010	NON-COMPETING CONTINUATION	$616,724
														Subtotal = $616,724

Issue Date FY: 2009 ( Subtotal = $773,810 )
2009	2009	ROCKEFELLER UNIVERSITY	EAST 66TH STREET & YORK AVENUE	NEW YORK	NY	10021	NEW YORK	USA	Arthritis, Musculoskeletal and Skin Diseases Research	001	27	9/16/2009	SUPPLEMENT FOR EXPANSION	$169,000
2009	2009	ROCKEFELLER UNIVERSITY	EAST 66TH STREET & YORK AVENUE	NEW YORK	NY	10021	NEW YORK	USA	Arthritis, Musculoskeletal and Skin Diseases Research	000	27	5/19/2009	NON-COMPETING CONTINUATION	$604,810
														Subtotal = $773,810

Issue Date FY: 2008 ( Subtotal = $587,196 )
2008	2008	ROCKEFELLER UNIVERSITY	EAST 66TH STREET & YORK AVENUE	NEW YORK	NY	10021	NEW YORK	USA	Arthritis, Musculoskeletal and Skin Diseases Research	000	26	5/9/2008	NON-COMPETING CONTINUATION	$587,196
														Subtotal = $587,196

Issue Date FY: 2007 ( Subtotal = $581,727 )
2007	2007	ROCKEFELLER UNIVERSITY	EAST 66TH STREET & YORK AVENUE	NEW YORK	NY	10021	NEW YORK	USA	Arthritis, Musculoskeletal and Skin Diseases Research	000	25	5/18/2007	NON-COMPETING CONTINUATION	$581,727
														Subtotal = $581,727

Issue Date FY: 2006 ( Subtotal = $581,652 )
2006	2006	ROCKEFELLER UNIVERSITY	EAST 66TH STREET & YORK AVENUE	NEW YORK	NY	10021	NEW YORK	USA	Arthritis, Musculoskeletal and Skin Diseases Research	000	24	6/15/2006	COMPETING CONTINUATION	$581,652
														Subtotal = $581,652

Issue Date FY: 2005 ( Subtotal = $859,017 )
2005	2005	ROCKEFELLER UNIVERSITY	EAST 66TH STREET & YORK AVENUE	NEW YORK	NY	10021	NEW YORK	USA	Arthritis, Musculoskeletal and Skin Diseases Research	000	23	7/25/2005	NON-COMPETING CONTINUATION	$859,017
														Subtotal = $859,017

Issue Date FY: 2004 ( Subtotal = $838,421 ) (Continued on the next page)
Grand Total All Awards = $17,101,887

Page 1 of 2 (64 items)12

Top

All Categories

About

Search

Reports

Data Submission

Award Information

Regulation of Epidermal Development and Differentiation

Award Number: R01AR031737

ORGANIZATION: NATIONAL INSTITUTE OF ARTHRITIS & MUSCULOSKELETAL & SKIN DISEASES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 01/01/1983

PERIOD OF PERFORMANCE END DATE: 04/30/2031

Federal Websites

Department of Health & Human Services

HHS Operating Divisions

HHS Staff Divisions

Download A Document Viewer