Wednesday, October 1, 2025 10/1/2025

Skin microbes and development of allergic disease

Award Number: R01AI192662
ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/05/2025
PERIOD OF PERFORMANCE END DATE: 08/31/2029

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Skin microbes and development of allergic disease - Project Summary/Abstract Bacteria that colonize the skin of adults with allergic diseases such as Atopic Dermatitis (AD) are different than those on healthy skin and influence severity of disease, but the function of the microbiome in early life is less well known. New data from a test cohort of children with AD has discovered that several strains of Streptococcus produce high protease activity, are more abundant on children with AD, and can induce skin barrier breakdown and Th2 inflammation on mice. Skin barrier defects associate with both AD and food allergy (FA). We therefore hypothesize that colonization by strains of Streptococci that can damage the skin barrier will increase the risk of development of allergic diseases such as AD and FA. To test this hypothesis, we propose to test skin swabs obtained from the SUNBEAM early life study. This study is collecting multiple swabs and other data from approximately 2000 children at birth until age 3. Analysis of bacterial protease activity, cytotoxic activity and antimicrobial activity will be conducted on approximately 6000 swabs to identify the genes in specific bacterial strains that are responsible for damaging and protective functions. Metagenomic and Metabolomic analysis will further clarify the composition and actions of the microbiome on the skin of participants in this study, thus providing essential information to enable better understanding of how the microbiome influences the onset of AD or FA. This information will further clarify how the functions of bacteria on the skin can impact the immune system.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $5,176,858 )
2025	2025	UNIVERSITY OF CALIFORNIA, SAN DIEGO	9500 GILMAN DR	LA JOLLA	CA	92093	SAN DIEGO	USA	Allergy and Infectious Diseases Research	000	1	9/5/2025	NEW	$5,176,858
														Subtotal = $5,176,858

Grand Total All Awards = $5,176,858

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Skin microbes and development of allergic disease

Award Number: R01AI192662

ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/05/2025

PERIOD OF PERFORMANCE END DATE: 08/31/2029

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