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Epitope-Paratope Characteristics and IgG1 Allostery in Fc-mediated Effector Function

Award Number: R01AI187023
ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 08/07/2025
PERIOD OF PERFORMANCE END DATE: 07/31/2030

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Epitope-Paratope Characteristics and IgG1 Allostery in Fc-mediated Effector Function - Project Summary This project seeks to enhance our understanding of the mechanisms underpinning Fc-mediated effector functions in the context of infectious diseases. Despite the role of Fc-mediated effector functions in bridging adaptive and innate immunity to combat various pathogens, certain infectious agents have evolved to evade these immune responses, potentially exacerbating disease progression. To counter this, our research aims to dissect the intricacies of Fc-mediated effector functions specifically targeting a viral surface protein. Our proposal sets forth a comprehensive analysis of the factors influencing Fc-mediated effector mechanisms for a viral surface protein by leveraging our novel assays for Fc-mediated effector functions. This assay has been instrumental in establishing a correlation between immune protection in a number of immunization and antibody therapy studies. Through a detailed exploration of how antibodies that recognize this viral protein enhance Fc- mediated effector functions, we aim to elucidate the structural and functional parameters that can be “tuned” to develop new antibody-based preventions and therapies. Further, this project will provide new insights on how the human immune system protects against infections as well as maintaining immune balance to prevent autoimmune diseases. .


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $463,676 )
2025	2025	UNIVERSITY OF MARYLAND, BALTIMORE	220 ARCH ST OFC LEVEL2	BALTIMORE	MD	21201	BALTIMORE CITY	USA	Allergy and Infectious Diseases Research	000	1	8/7/2025	NEW	$463,676
														Subtotal = $463,676

Grand Total All Awards = $463,676

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Epitope-Paratope Characteristics and IgG1 Allostery in Fc-mediated Effector Function

Award Number: R01AI187023

ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 08/07/2025

PERIOD OF PERFORMANCE END DATE: 07/31/2030

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