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Chemoproteomic discovery and functional analysis microbiota bile acid-protein targets in host immunity

Award Number: R01AI182439
ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 12/09/2024
PERIOD OF PERFORMANCE END DATE: 11/30/2029

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Chemoproteomic discovery and functional analysis microbiota bile acid-protein targets in host immunity - PROJECT SUMMARY Key metabolites from intestinal microbiota can modulate host immune responses, but their mechanisms of action are unclear and limit the development of new therapeutic approaches in human health and disease. To determine the mechanism(s) of action of prominent microbiota metabolites (short chain fatty acids, aromatic amino acids, bile acids and others), multi-disciplinary approaches are needed to biochemically identify metabolite-protein targets in mammalian cells and characterize their activity on host immunity in vivo. For this grant application, our laboratories will focus on microbiota-associated bile acids and employ innovative methods in chemical biology and proteomics to identify their protein targets in mammalian cells and characterize their mechanism(s) of action on host immunity in vitro, ex vivo and in mouse models in vivo. A better understanding of how these microbiota metabolites affects host immunity should reveal potential therapeutic targets and facilitate the development of therapeutic approaches against infection and cancer in animals and humans.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $891,678 )
2025	2025	SCRIPPS RESEARCH INSTITUTE	10550 N TORREY PINES RD	LA JOLLA	CA	92037	SAN DIEGO	USA	Allergy and Infectious Diseases Research	000	1	12/9/2024	NEW	$891,678
														Subtotal = $891,678

Grand Total All Awards = $891,678

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Chemoproteomic discovery and functional analysis microbiota bile acid-protein targets in host immunity

Award Number: R01AI182439

ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 12/09/2024

PERIOD OF PERFORMANCE END DATE: 11/30/2029

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