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Harnessing commensal redox metabolism in infection prevention

Award Number: R01AI179807
ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 11/24/2023
PERIOD OF PERFORMANCE END DATE: 10/31/2028

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Harnessing commensal redox metabolism in infection prevention - Abstract: Many gut-infecting bacterial pathogens undergo growth expansion in the gut lumen as part of the virulence, and as supported by their underlying metabolism. Commensal metabolism in the gut provides an opportunity to impede these processes by depriving pathogens of growth- promoting nutrients. Using the amino acid and carbohydrate-fermenting pathogen Clostridioides difficile, we will evaluate how redox metabolism of target carbon sources by the pathogen and commensals can enhance or limit its ability to colonize and infect the gut. Analyses will leverage innovative approaches to track nutrient flow among pathogen, commensal, and host tissues. Studies will further perturb host environments using carbon sources that are fermented by the pathogen, protective commensals, or both, to assess their role in disease pathogenesis and progression. Findings will inform small molecule and bacteriotherapeutic interventions in disease prevention and treatment.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $849,858 )
2026	2026	BRIGHAM & WOMENS HOSPITAL INC	75 FRANCIS ST	BOSTON	MA	02115	SUFFOLK	USA	Allergy and Infectious Diseases Research	000	3	12/4/2025	NON-COMPETING CONTINUATION	$849,858
														Subtotal = $849,858

Issue Date FY: 2025 ( Subtotal = $849,858 )
2025	2025	BRIGHAM & WOMENS HOSPITAL INC	75 FRANCIS ST	BOSTON	MA	02115	SUFFOLK	USA	Allergy and Infectious Diseases Research	000	2	12/5/2024	NON-COMPETING CONTINUATION	$849,858
														Subtotal = $849,858

Issue Date FY: 2024 ( Subtotal = $841,796 )
2024	2024	BRIGHAM & WOMENS HOSPITAL INC	75 FRANCIS ST	BOSTON	MA	02115	SUFFOLK	USA	Allergy and Infectious Diseases Research	001	1	9/11/2024	NEW	$82,206
2024	2024	BRIGHAM & WOMENS HOSPITAL INC	75 FRANCIS ST	BOSTON	MA	02115	SUFFOLK	USA	Allergy and Infectious Diseases Research	000	1	11/24/2023	NEW	$759,590
														Subtotal = $841,796

Grand Total All Awards = $2,541,512

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Harnessing commensal redox metabolism in infection prevention

Award Number: R01AI179807

ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 11/24/2023

PERIOD OF PERFORMANCE END DATE: 10/31/2028

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