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Fungal regulatory systems directing mammalian host colonization

Award Number: R01AI175081
ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 03/02/2023
PERIOD OF PERFORMANCE END DATE: 02/29/2028

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Fungal regulatory systems directing mammalian host colonization - ABSTRACT The fungus Candida albicans is a ubiquitous member of the human gut microbiota, yet also causes mucosal disease and life-threatening disseminated infections. The research program that I describe here seeks to understand the links between the fungus' facet as intestinal commensal and its ability to proliferate in disparate organs. The program is built upon recent findings from my laboratory which ¾ through systematic genetic screens conducted in mouse models of gut colonization, oropharyngeal candidiasis and disseminated infections ¾ reveal that fungal genetic determinants of fitness in the gut also shape the interactions of the fungus with other tissues. The proposed study encompasses three specific directions: (i) elucidating the mechanisms of activation and inhibition of a regulator of fungal sphingolipids which is active in the gut and inside human neutrophils; (ii) defining the effector genes and extracellular cue(s) of a regulator that promotes binding to intestinal mucus; and (iii) identifying C. albicans gene products that enable the fungus to inhabit the intestinal mucus layer. The proposed research is expected to reveal basic principles underlying the interplay between mammalian host and the most prominent fungus residing in humans.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $479,480 )
2026	2026	UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT HOUSTON	7000 FANNIN ST FL 9	HOUSTON	TX	77030	HARRIS	USA	Allergy and Infectious Diseases Research	000	4	2/10/2026	NON-COMPETING CONTINUATION	$479,480
														Subtotal = $479,480

Issue Date FY: 2025 ( Subtotal = $465,096 )
2025	2025	UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT HOUSTON	7000 FANNIN ST FL 9	HOUSTON	TX	77030	HARRIS	USA	Allergy and Infectious Diseases Research	000	3	2/13/2025	NON-COMPETING CONTINUATION	$465,096
														Subtotal = $465,096

Issue Date FY: 2024 ( Subtotal = $479,480 )
2024	2024	UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT HOUSTON	7000 FANNIN ST FL 9	HOUSTON	TX	77030	HARRIS	USA	Allergy and Infectious Diseases Research	001	2	5/23/2024	NON-COMPETING CONTINUATION	$47,948
2024	2024	UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT HOUSTON	7000 FANNIN ST FL 9	HOUSTON	TX	77030	HARRIS	USA	Allergy and Infectious Diseases Research	000	2	2/22/2024	NON-COMPETING CONTINUATION	$431,532
														Subtotal = $479,480

Issue Date FY: 2023 ( Subtotal = $479,480 )
2023	2023	UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT HOUSTON, THE	7000 FANNIN ST	HOUSTON	TX	77030	HARRIS	USA	Allergy and Infectious Diseases Research	000	1	3/2/2023	NEW	$479,480
														Subtotal = $479,480

Grand Total All Awards = $1,903,536

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Fungal regulatory systems directing mammalian host colonization

Award Number: R01AI175081

ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 03/02/2023

PERIOD OF PERFORMANCE END DATE: 02/29/2028

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