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Impact of Early-life Exposure to Semi-Volatile Organic Compounds (SVOCs) on Neonatal and Early Childhood Immune Function

Award Number: R01AI167850
ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 04/21/2022
PERIOD OF PERFORMANCE END DATE: 03/31/2027

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Impact of Early-life Exposure to Semi-Volatile Organic Compounds (SVOCs) on Neonatal and Early Childhood Immune Function - Project Summary The immune system plays a critical role in maintaining a child’s health, and immune deficits may have serious consequences ranging from increased susceptibility to infections to allergic and autoimmune conditions. Although many factors contribute to overall immune health, emerging data suggest that early life environmental exposures interfere with immune development and function. Identifying modifiable environmental factors that affect children’s immunity, our overarching goal is critical to reducing infant morbidity and mortality and has long- term implications for improving health. Semi-volatile organic compounds (SVOCs), including organophosphate esters, phthalates, pesticides, and flame retardants, are used in consumer and personal care products, electronics, furniture, and building materials. As a result of their extensive use and environmental persistence, SVOCs are detected with high frequency in indoor environments, and human exposure to mixtures of SVOCs is widespread. Our proposed research assesses exposure to SVOC mixtures throughout pregnancy and in infancy. We will investigate individual characteristics associated with higher levels of exposure and evaluate the potential for adverse health outcomes among exposed women and their children. Animal studies provide compelling evidence that exposure to individual SVOCs impacts immune function; however, the extent to which these studies extend to human populations is unclear, particularly because they largely consider exposure to single chemicals, which does not reflect real-world exposures (i.e., those occurring in mixtures). Our primary objective is to investigate the impacts of early life exposure to SVOC mixtures on children’s immune function, and in doing so, to fill a critical gap in the understanding of the impacts of SVOCs. This study will be the first to evaluate the role of SVOC in altering the protection of the neonate by evaluating the two most critical aspects of early life immune function: 1) passive transfer of immunity and 2) the capacity to respond to a novel pathogen-associated antigen. We will capitalize on the infrastructure of HOPE 1000, an ongoing cohort study with longitudinal collection of SVOC exposure monitors during each trimester of pregnancy and in early childhood, and the biospecimen needed to evaluate immune function and pathogen immunity. Identifying specific SVOCs or mixtures of SVOCs that affect immunity may provide new opportunities for interventions at the individual and policy levels. Such data are critically needed as the use of some SVOCs is predicted to increase in the coming years.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $664,140 )
2026	2026	DUKE UNIVERSITY	2200 W MAIN ST	DURHAM	NC	27705	DURHAM	USA	Allergy and Infectious Diseases Research	000	5	4/2/2026	NON-COMPETING CONTINUATION	$664,140
														Subtotal = $664,140

Issue Date FY: 2025 ( Subtotal = $745,302 )
2025	2025	DUKE UNIVERSITY	2200 W MAIN ST	DURHAM	NC	27705	DURHAM	USA	Allergy and Infectious Diseases Research	000	4	5/5/2025	NON-COMPETING CONTINUATION	$745,302
														Subtotal = $745,302

Issue Date FY: 2024 ( Subtotal = $760,647 )
2024	2024	DUKE UNIVERSITY	2200 W MAIN ST	DURHAM	NC	27705	DURHAM	USA	Allergy and Infectious Diseases Research	000	3	3/19/2024	NON-COMPETING CONTINUATION	$760,647
														Subtotal = $760,647

Issue Date FY: 2023 ( Subtotal = $742,058 )
2023	2023	DUKE UNIVERSITY	2200 W MAIN ST	DURHAM	NC	27705	DURHAM	USA	Allergy and Infectious Diseases Research	000	2	3/16/2023	NON-COMPETING CONTINUATION	$742,058
														Subtotal = $742,058

Issue Date FY: 2022 ( Subtotal = $716,067 )
2022	2022	DUKE UNIVERSITY	2200 W MAIN ST STE 710	DURHAM	NC	27708	DURHAM	USA	Allergy and Infectious Diseases Research	000	1	4/21/2022	NEW	$716,067
														Subtotal = $716,067

Grand Total All Awards = $3,628,214

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Impact of Early-life Exposure to Semi-Volatile Organic Compounds (SVOCs) on Neonatal and Early Childhood Immune Function

Award Number: R01AI167850

ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 04/21/2022

PERIOD OF PERFORMANCE END DATE: 03/31/2027

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