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Chromatin architecture as a regulator of dendritic cell function

Award Number: R01AI164728
ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 03/17/2022
PERIOD OF PERFORMANCE END DATE: 09/30/2025

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Chromatin architecture as a regulator of dendritic cell function - PROJECT ABSTRACT Dendritic cells (DCs) are immune sentinel cells that can be activated by innate stimuli to orchestrate adaptive immune responses. Conventional DCs (cDCs) efficiently present and cross-present antigens to prime T cell responses, whereas plasmacytoid DCs (pDCs) rapidly produce type I interferon (IFN-α/β, IFN-I) and other cytokines in response to pathogen-derived nucleic acids. Recent studies revealed an intricate topological organization of the genome into topologically associated domains (TADs) established through cohesin- mediated loop extrusion and demarcated by binding sites of transcription factor CTCF. CTCF/cohesin- mediated chromatin architecture is thought to control cell type-specific gene expression programs, thereby facilitating cell differentiation and function. However, the topological chromatin landscapes of DCs and their role in DC differentiation and function are poorly understood. The overall goal of the project is to characterize the chromatin architecture in DCs and elucidate the chromatin-level control of DC function. In Aim 1, we will examine the role of CTCF/cohesin-mediated regulation in the differentiation of DC subsets. In Aim 2, we will analyze the role of cohesin in DC function, including cytokine responses and antigen presentation. In Aim 3, we will analyze the architecture of the locus encoding IFN-I genes, and the role of chromatin in the control of interferon production in DCs. Collectively, these results would provide novel insights into the role and mechanism of chromosomal organization in the regulation of DC differentiation and function.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $543,488 )
2026	2026	UNIVERSITY OF CHICAGO	5801 S ELLIS AVE	CHICAGO	IL	60637	COOK	USA	Allergy and Infectious Diseases Research	001	5	4/8/2026	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$543,488
2026	2025	NEW YORK UNIVERSITY	550 1ST AVE	NEW YORK	NY	10016	NEW YORK	USA	Allergy and Infectious Diseases Research	000	4	3/30/2026	NON-COMPETING CONTINUATION	$0
2026	2025	NEW YORK UNIVERSITY	550 1ST AVE	NEW YORK	NY	10016	NEW YORK	USA	Allergy and Infectious Diseases Research	002	4	4/28/2026	NON-COMPETING CONTINUATION	$0
														Subtotal = $543,488

Issue Date FY: 2025 ( Subtotal = $530,941 )
2025	2025	NEW YORK UNIVERSITY	550 1ST AVE	NEW YORK	NY	10016	NEW YORK	USA	Allergy and Infectious Diseases Research	000	4	2/13/2025	NON-COMPETING CONTINUATION	$530,941
														Subtotal = $530,941

Issue Date FY: 2024 ( Subtotal = $547,361 )
2024	2024	NEW YORK UNIVERSITY	550 1ST AVE	NEW YORK	NY	10016	NEW YORK	USA	Allergy and Infectious Diseases Research	001	3	5/23/2024	NON-COMPETING CONTINUATION	$54,736
2024	2024	NEW YORK UNIVERSITY	550 1ST AVE	NEW YORK	NY	10016	NEW YORK	USA	Allergy and Infectious Diseases Research	000	3	2/22/2024	NON-COMPETING CONTINUATION	$492,625
														Subtotal = $547,361

Issue Date FY: 2023 ( Subtotal = $547,361 )
2023	2023	NEW YORK UNIVERSITY	550 1ST AVE	NEW YORK	NY	10016	NEW YORK	USA	Allergy and Infectious Diseases Research	000	2	2/24/2023	NON-COMPETING CONTINUATION	$547,361
														Subtotal = $547,361

Issue Date FY: 2022 ( Subtotal = $579,256 )
2022	2022	NEW YORK UNIVERSITY	550 1ST AVE	NEW YORK	NY	10016	NEW YORK	USA	Allergy and Infectious Diseases Research	000	1	3/17/2022	NEW	$579,256
														Subtotal = $579,256

Grand Total All Awards = $2,748,407

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Chromatin architecture as a regulator of dendritic cell function

Award Number: R01AI164728

ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 03/17/2022

PERIOD OF PERFORMANCE END DATE: 09/30/2025

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