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COVID Global Mix - Global Mix / Investigation of COVID-19 Disease Parameters for Transmission Models in Low-Resource Settings

Award Number: R01AI161399
ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 03/01/2025
PERIOD OF PERFORMANCE END DATE: 02/28/2027

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COVID Global Mix - Global Mix / Investigation of COVID-19 Disease Parameters for Transmission Models in Low-Resource Settings - PROJECT SUMMARY - We began to quantify household- and community-level interactions in 2019 with our project, “Comprehensive Profiling of Social Mixing Patterns in Resource Poor Countries” (“GlobalMix”, grant R01 HD097175-01) to investigate human-to-human interactions relevant for respiratory infection transmission. This proposal will build on existing GlobalMix study infrastructure to estimate LMIC-specific epidemiologic parameters for COVID-19. In the proposed study, we will connect field epidemiology and mathematical modeling approaches by estimating the rate of, and heterogeneity in, household-based transmission of SARS- CoV-2 through longitudinal cohort approaches. We will use this information in conjunction with highly-granular data on social interactions from GlobalMix to identify key epidemiological parameters for COVID-19, including the community-level force of infection and attack rates within households. We will then use this information to build LMIC-specific dynamic models, to evaluate the impact of key interventions to reduce transmission: vaccination and non-pharmaceutical interventions such as face masks, shelter-in-place policies and school closure. This work will be completed in three specific aims: Aim 1: Quantify COVID-19 transmission across contact networks within the household environment. We will conduct longitudinal respiratory disease surveillance in households participating in the GlobalMix study. We will collect longitudinal samples of respiratory specimens from household members for identification of COVID-19 and other respiratory pathogens such as influenza. This information will be overlaid on contact network data from GlobalMix. Aim 2: Estimate key epidemiological features of SARS-CoV-2 and other respiratory pathogens in LMIC settings. We will collect blood specimens from GlobalMix study participants and test for antibody levels (IgG) against SARS-CoV-2. We will calculate age-specific infection fatality rates (IFRs) and use antibody titers to infer time of infection and calculate community-level incidence over time. We will generate age-structured seroprevalence curves, which will provide a robust measure of exposure across the age range. Together with the contact data from GlobalMix, we will infer age-specific transmission probabilities that will be used as inputs into the network models in Aim 3. Samples will be stored for future testing, including antibody avidity and T/B cell activation. Aim 3. Estimate the impact of control measures on COVID-19 in LMIC. We will use the epidemiological parameters estimated in Aim 1 and the setting- and age-specific force of infection estimates from Aim 2 to parameterize dynamic network-based mathematical models of disease transmission. Models will incorporate social mixing data from GlobalMix to project the impact of extended shelter-in-place policies, policies concerning the use of face masks, and the introduction of a SARS-CoV-2 vaccine.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $622,456 )
2025	2025	THE UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER	5323 HARRY HINES BLVD	DALLAS	TX	75390	DALLAS	USA	Allergy and Infectious Diseases Research	001	5	9/8/2025	SUPPLEMENT FOR EXPANSION	$5,259
2025	2025	THE UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER	5323 HARRY HINES BLVD	DALLAS	TX	75390	DALLAS	USA	Allergy and Infectious Diseases Research	003	5	9/8/2025	SUPPLEMENT FOR EXPANSION	$48,219
2025	2025	THE UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER	5323 HARRY HINES BLVD	DALLAS	TX	75390	DALLAS	USA	Allergy and Infectious Diseases Research	002	5	9/8/2025	SUPPLEMENT FOR EXPANSION	$168,350
2025	2025	THE UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER	5323 HARRY HINES BLVD	DALLAS	TX	75390	DALLAS	USA	Allergy and Infectious Diseases Research	000	5	9/5/2025	NON-COMPETING CONTINUATION	$400,628
														Subtotal = $622,456

Issue Date FY: 2024 ( Subtotal = $641,004 )
2024	2024	THE UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER	5323 HARRY HINES BLVD	DALLAS	TX	75390	DALLAS	USA	Allergy and Infectious Diseases Research	002	4	9/5/2024	NON-COMPETING CONTINUATION	$0
2024	2024	UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER, THE	5323 HARRY HINES BLVD	DALLAS	TX	75390	DALLAS	USA	Allergy and Infectious Diseases Research	000	4	3/5/2024	NON-COMPETING CONTINUATION	$576,903
2024	2024	THE UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER	5323 HARRY HINES BLVD	DALLAS	TX	75390	DALLAS	USA	Allergy and Infectious Diseases Research	001	4	5/24/2024	NON-COMPETING CONTINUATION	$64,101
														Subtotal = $641,004

Issue Date FY: 2023 ( Subtotal = $699,164 )
2023	2023	YALE UNIVERSITY	105 WALL ST	NEW HAVEN	CT	06511	SOUTH CENTRAL CT	USA	Allergy and Infectious Diseases Research	001	2	7/26/2023	NON-COMPETING CONTINUATION	-$429,037
2023	2023	YALE UNIVERSITY	105 WALL ST	NEW HAVEN	CT	06511	SOUTH CENTRAL CT	USA	Allergy and Infectious Diseases Research	004	2	8/29/2023	NON-COMPETING CONTINUATION	-$270,127
2023	2023	YALE UNIVERSITY	105 WALL ST	NEW HAVEN	CT	06511	SOUTH CENTRAL CT	USA	Allergy and Infectious Diseases Research	000	2	2/23/2023	NON-COMPETING CONTINUATION	$699,164
2023	2023	UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER, THE	5323 HARRY HINES BLVD	DALLAS	TX	75390	DALLAS	USA	Allergy and Infectious Diseases Research	005	3	8/29/2023	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$464,178
2023	2023	UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER, THE	5323 HARRY HINES BLVD	DALLAS	TX	75390	DALLAS	USA	Allergy and Infectious Diseases Research	002	3	7/27/2023	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$429,037
2023	2022	YALE UNIVERSITY	105 WALL ST	NEW HAVEN	CT	06511	SOUTH CENTRAL CT	USA	Allergy and Infectious Diseases Research	003	1	8/29/2023	NEW	-$194,051
														Subtotal = $699,164

Issue Date FY: 2022 ( Subtotal = $785,776 )
2022	2022	YALE UNIVERSITY	105 WALL ST	NEW HAVEN	CT	06511	SOUTH CENTRAL CT	USA	Allergy and Infectious Diseases Research	000	1	2/22/2022	NEW	$785,776
														Subtotal = $785,776

Grand Total All Awards = $2,748,400

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COVID Global Mix - Global Mix / Investigation of COVID-19 Disease Parameters for Transmission Models in Low-Resource Settings

Award Number: R01AI161399

ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 03/01/2025

PERIOD OF PERFORMANCE END DATE: 02/28/2027

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