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Systems-level identification of key regulators deciding immune cell state

Award Number: R01AI150282
ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 04/01/2020
PERIOD OF PERFORMANCE END DATE: 03/31/2025

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Systems-level identification of key regulators deciding immune cell state - Abstract Understanding the mechanisms and identifying regulators of immune cell development and differentiation are critical for developing new and more effective therapeutics. The fast advancement of genomic technologies provides an unprecedented opportunity to study the immune cells at the system level. The noise in the high throughput measurements and the complexity of multiple omics data make it an urgent need for developing novel and powerful systems biology approach for integrative analysis to reveal the underlying regulatory mechanisms for immune system. We propose a new method to integrate multiomics data at the genetic network level for identification of key regulators deciding the cell state and cell fate (Specific Aim 1). We will apply the method to systematically uncover the regulatory mechanisms in the mouse immune system by analyzing 86 immune cell populations (Specific Aim 2). We will also perform comparative analysis of the human and mouse immune cells to reveal the conserved regulatory code for immune cell specification (Specific Aim 3). We will rigorously assess the performance of the computational analysis, experimentally confirm the importance of the identified key regulators and investigate their roles in regulating immune cell functions. Once complete, the proposed work will provide not only a general tool for integrative analysis of multiomics data but also specific mechanistic insights for understanding the regulation of immune system functions.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = $700,299 )
2024	2024	UNIVERSITY OF CALIFORNIA, SAN DIEGO	9500 GILMAN DR	LA JOLLA	CA	92093	SAN DIEGO	USA	Allergy and Infectious Diseases Research	000	5	3/14/2024	NON-COMPETING CONTINUATION	$700,299
														Subtotal = $700,299

Issue Date FY: 2023 ( Subtotal = $700,299 )
2023	2023	UNIVERSITY OF CALIFORNIA, SAN DIEGO	9500 GILMAN DRIVE	LA JOLLA	CA	92093	SAN DIEGO	USA	Allergy and Infectious Diseases Research	000	4	3/28/2023	NON-COMPETING CONTINUATION	$700,299
														Subtotal = $700,299

Issue Date FY: 2022 ( Subtotal = $720,299 )
2022	2022	UNIVERSITY OF CALIFORNIA, SAN DIEGO	9500 GILMAN DR	LA JOLLA	CA	92093	SAN DIEGO	USA	Allergy and Infectious Diseases Research	000	3	3/2/2022	NON-COMPETING CONTINUATION	$720,299
														Subtotal = $720,299

Issue Date FY: 2021 ( Subtotal = $699,745 )
2021	2021	UNIVERSITY OF CALIFORNIA, SAN DIEGO	9500 GILMAN DR	LA JOLLA	CA	92093	SAN DIEGO	USA	Allergy and Infectious Diseases Research	000	2	3/15/2021	NON-COMPETING CONTINUATION	$699,745
														Subtotal = $699,745

Issue Date FY: 2020 ( Subtotal = $718,083 )
2020	2020	UNIVERSITY OF CALIFORNIA, SAN DIEGO	9500 GILMAN DR	LA JOLLA	CA	92093	SAN DIEGO	USA	Allergy and Infectious Diseases Research	000	1	3/24/2020	NEW	$718,083
														Subtotal = $718,083

Grand Total All Awards = $3,538,725

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Systems-level identification of key regulators deciding immune cell state

Award Number: R01AI150282

ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 04/01/2020

PERIOD OF PERFORMANCE END DATE: 03/31/2025

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