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Subtractive assembly approaches for inferring disease-associated microbial genes and pathways from microbiome sequencing data

Award Number: R01AI143254
ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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Summary Successful translational applications of microbiome research rely on computational tools that can effectively detect microbial markers that are associated with diseases, and provide explanations to the associations. We propose to develop subtractive assembly approaches to microbiome sequencing data analysis, aiming to identity microbial genes and pathways that are associated with diseases. The advantages of using subtractive assembly approaches include: 1) they significantly reduce the complexity of the fragment assembly problem by focusing only on the potential difference (genes and genomes) at the initial (instead of the final) stage of the comparative analysis pipeline, and 2) they improve the assemblies of differential genes, which are important inputs for building predictive models for disease diagnosis and characterization of treatment efficacy. We will apply our new tools to analyzing disease-associated microbiomes including those associated with type II diabetes, liver cancer, inflammatory bowel disease (IBD) and those known to be related to the efficacy of cancer immunotherapy.


Issue Date FY	Funding FY	Recipient Name	DUNS Number	City	State	CFDA Number	CFDA Program Title	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2021 ( Subtotal = $270,268 )
2021	2021	INDIANA UNIVERSITY, BLOOMINGTON	006046700	BLOOMINGTON	IN	93.855	Allergy and Infectious Diseases Research	000	3	11/23/2020	NON-COMPETING CONTINUATION	$270,268


Issue Date FY: 2020 ( Subtotal = $270,268 )
2020	2020	INDIANA UNIVERSITY, BLOOMINGTON	006046700	BLOOMINGTON	IN	93.855	Allergy and Infectious Diseases Research	000	2	11/6/2019	NON-COMPETING CONTINUATION	$270,268


Issue Date FY: 2019 ( Subtotal = $264,518 )
2019	2019	INDIANA UNIVERSITY, BLOOMINGTON	006046700	BLOOMINGTON	IN	93.855	Allergy and Infectious Diseases Research	000	1	11/2/2018	NEW	$264,518


Grand Total All Awards = $805,054

Sum of Action Amount is $805,054;

Grand Total = $805,054

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Subtractive assembly approaches for inferring disease-associated microbial genes and pathways from microbiome sequencing data

Award Number: R01AI143254

ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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