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Subtractive assembly approaches for inferring disease-associated microbial genes and pathways from microbiome sequencing data

Award Number: R01AI143254
ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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Subtractive assembly approaches for inferring disease-associated microbial genes and pathways from microbiome sequencing data - Summary Successful translational applications of microbiome research rely on computational tools that can effectively detect microbial markers that are associated with diseases, and provide explanations to the associations. We propose to develop subtractive assembly approaches to microbiome sequencing data analysis, aiming to identity microbial genes and pathways that are associated with diseases. The advantages of using subtractive assembly approaches include: 1) they significantly reduce the complexity of the fragment assembly problem by focusing only on the potential difference (genes and genomes) at the initial (instead of the final) stage of the comparative analysis pipeline, and 2) they improve the assemblies of differential genes, which are important inputs for building predictive models for disease diagnosis and characterization of treatment efficacy. We will apply our new tools to analyzing disease-associated microbiomes including those associated with type II diabetes, liver cancer, inflammatory bowel disease (IBD) and those known to be related to the efficacy of cancer immunotherapy.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $0 )
2025	2023	TRUSTEES OF INDIANA UNIVERSITY	107 S INDIANA AVE	BLOOMINGTON	IN	47405	MONROE	USA	Allergy and Infectious Diseases Research	000	4	4/16/2025	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2023 ( Subtotal = $309,643 )
2023	2023	TRUSTEES OF INDIANA UNIVERSITY	107 S INDIANA AVE	BLOOMINGTON	IN	47405	MONROE	USA	Allergy and Infectious Diseases Research	000	4	10/24/2022	NON-COMPETING CONTINUATION	$309,643
														Subtotal = $309,643

Issue Date FY: 2022 ( Subtotal = $0 )
2022	2021	TRUSTEES OF INDIANA UNIVERSITY	107 S INDIANA AVE	BLOOMINGTON	IN	47405	MONROE	USA	Allergy and Infectious Diseases Research	000	3	11/5/2021	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2021 ( Subtotal = $270,268 )
2021	2021	TRUSTEES OF INDIANA UNIVERSITY	107 S INDIANA AVENUE	BLOOMINGTON	IN	47405	MONROE	USA	Allergy and Infectious Diseases Research	000	3	11/23/2020	NON-COMPETING CONTINUATION	$270,268
														Subtotal = $270,268

Issue Date FY: 2020 ( Subtotal = $270,268 )
2020	2020	TRUSTEES OF INDIANA UNIVERSITY	BRYAN HALL 107 S INDIANA AVENUE	BLOOMINGTON	IN	47405	MONROE	USA	Allergy and Infectious Diseases Research	000	2	11/6/2019	NON-COMPETING CONTINUATION	$270,268
														Subtotal = $270,268

Issue Date FY: 2019 ( Subtotal = $264,518 )
2019	2019	TRUSTEES OF INDIANA UNIVERSITY	BRYAN HALL 107 S INDIANA AVENUE	BLOOMINGTON	IN	47405	MONROE	USA	Allergy and Infectious Diseases Research	000	1	11/2/2018	NEW	$264,518
														Subtotal = $264,518

Grand Total All Awards = $1,114,697

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Subtractive assembly approaches for inferring disease-associated microbial genes and pathways from microbiome sequencing data

Award Number: R01AI143254

ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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