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Site Specific Immunophenotyping Assays of COVID19 Patients to Align with NIAID National Study

Award Number: R01AI141953
ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 06/01/2020
PERIOD OF PERFORMANCE END DATE: 05/31/2023

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Site Specific Immunophenotyping Assays of COVID19 Patients to Align with NIAID National Study - Project Summary The NIAID national protocol intends to enroll at least 1000 COVID19 patients in a study designed to track infected patients through tracking, over time, their immune responses, viral load, and a variety of multi-omic analytes that can provide deep insights into how infection by SARS-CoV-2 is revealed in host defense responses and disease- perturbed networks. At the heart of this study is the establishment of high quality biorepositories that can be used to quantitatively assess viral load, quantitatively interrogate viable PBMCs, and permit direct comparisons between different patients and different time points of disease progression. The nature of the infection, with highly differential patient outcomes, will eventually require significant computational efforts that can account for confounding factors such as co-morbidities, the influence of various therapies that are being broadly tested in these patients, etc. It will also certainly require both broadly available immune characterization tools that can be applied on all patient samples, but also specialized tools that can be used to inform the interpretation of the general analytics. In this project, we propose to integrate two sets of immune cell characterizations into the national NIAID effort. Those characterizations include single cell, functional phenotyping of select immune cell classes via an analysis designed to quantitate the levels of 35 secreted proteins from up to 2000 single cells of a given immune cell type. The second characterization is based upon reducing proteins from the SARS-CoV-2 into peptide antigen-major histocompatibility complex (pMHC) libraries that can be used to identify SARS-CoV- 2 antigen-specific CD8+ and CD4+ T cell populations from isolated, viable PBMCs. These assays provide deep and complementary information that will significantly inform the interpretation of the immune phenotyping assays that constitute the COREs of the NIAID study.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = -$45,643 )
2025	2021	INSTITUTE FOR SYSTEMS BIOLOGY	401 TERRY AVE N	SEATTLE	WA	98109	KING	USA	Allergy and Infectious Diseases Research	000	3	10/24/2024	SUPPLEMENT FOR EXPANSION	-$45,643
														Subtotal = -$45,643

Issue Date FY: 2023 ( Subtotal = $871,106 )
2023	2023	INSTITUTE FOR SYSTEMS BIOLOGY	401 TERRY AVE N	SEATTLE	WA	98109	KING	USA	Allergy and Infectious Diseases Research	000	5	5/26/2023	NON-COMPETING CONTINUATION	$871,106
														Subtotal = $871,106

Issue Date FY: 2022 ( Subtotal = $869,107 )
2022	2022	INSTITUTE FOR SYSTEMS BIOLOGY	401 TERRY AVE N	SEATTLE	WA	98109	KING	USA	Allergy and Infectious Diseases Research	002	4	5/25/2022	NON-COMPETING CONTINUATION	$869,107
2022	2021	INSTITUTE FOR SYSTEMS BIOLOGY	401 TERRY AVE N	SEATTLE	WA	98109	KING	USA	Allergy and Infectious Diseases Research	000	3	5/4/2022	SUPPLEMENT FOR EXPANSION	$0
2022	2021	INSTITUTE FOR SYSTEMS BIOLOGY	401 TERRY AVE N	SEATTLE	WA	98109	KING	USA	Allergy and Infectious Diseases Research	001	3	5/4/2022	SUPPLEMENT FOR EXPANSION	$0
														Subtotal = $869,107

Issue Date FY: 2021 ( Subtotal = $1,016,001 )
2021	2021	INSTITUTE FOR SYSTEMS BIOLOGY	401 TERRY AVE N	SEATTLE	WA	98109	KING	USA	Allergy and Infectious Diseases Research	002	3	6/11/2021	SUPPLEMENT FOR EXPANSION	$76,331
2021	2021	INSTITUTE FOR SYSTEMS BIOLOGY	401 TERRY AVE N	SEATTLE	WA	98109	KING	USA	Allergy and Infectious Diseases Research	001	3	6/10/2021	SUPPLEMENT FOR EXPANSION	$50,942
2021	2021	INSTITUTE FOR SYSTEMS BIOLOGY	401 TERRY AVE N	SEATTLE	WA	98109	KING	USA	Allergy and Infectious Diseases Research	000	3	6/8/2021	NON-COMPETING CONTINUATION	$888,728
														Subtotal = $1,016,001

Issue Date FY: 2020 ( Subtotal = $2,003,501 )
2020	2020	INSTITUTE FOR SYSTEMS BIOLOGY	401 TERRY AVE N	SEATTLE	WA	98109	KING	USA	Allergy and Infectious Diseases Research	000	2	5/6/2020	NON-COMPETING CONTINUATION	$900,470
2020	2020	INSTITUTE FOR SYSTEMS BIOLOGY	401 TERRY AVE N	SEATTLE	WA	98109	KING	USA	Allergy and Infectious Diseases Research	003	2	5/22/2020	SUPPLEMENT FOR EXPANSION	$441,482
2020	2020	INSTITUTE FOR SYSTEMS BIOLOGY	401 TERRY AVE N	SEATTLE	WA	98109	KING	USA	Allergy and Infectious Diseases Research	001	2	5/21/2020	SUPPLEMENT FOR EXPANSION	$661,549
2020	2020	INSTITUTE FOR SYSTEMS BIOLOGY	401 TERRY AVE N	SEATTLE	WA	98109	KING	USA	Allergy and Infectious Diseases Research	002	2	5/22/2020	NON-COMPETING CONTINUATION	$0
														Subtotal = $2,003,501

Issue Date FY: 2019 ( Subtotal = $927,560 )
2019	2019	INSTITUTE FOR SYSTEMS BIOLOGY	401 TERRY AVE N	SEATTLE	WA	98109	KING	USA	Allergy and Infectious Diseases Research	000	1	6/5/2019	NEW	$927,560
														Subtotal = $927,560

Grand Total All Awards = $5,641,632

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Site Specific Immunophenotyping Assays of COVID19 Patients to Align with NIAID National Study

Award Number: R01AI141953

ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 06/01/2020

PERIOD OF PERFORMANCE END DATE: 05/31/2023

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