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 | Issue Date FY: 2022 ( Subtotal = $9,937,093 ) |
| | 2022 | 2022 | INSTITUTE FOR SYSTEMS BIOLOGY | 401 TERRY AVE N | SEATTLE | WA | 98109-5263 | KING | USA | R01HG002939 | Development and Maintenance of RepeatMasker and RepeatModeler | 002 | 16 | NIH | 5/3/2022 | $1,588 |
| | 2022 | 2022 | INSTITUTE FOR SYSTEMS BIOLOGY | 401 TERRY AVE N | SEATTLE | WA | 98109-5263 | KING | USA | R01CA259469 | Systems biology of intratumoral heterogeneity in glioblastoma | 000 | 1 | NIH | 12/24/2021 | $765,787 |
| | 2022 | 2022 | INSTITUTE FOR SYSTEMS BIOLOGY | 401 TERRY AVE N | SEATTLE | WA | 98109-5263 | KING | USA | R01CA259469 | Systems biology of intratumoral heterogeneity in glioblastoma | 001 | 1 | NIH | 1/6/2022 | $0 |
| | 2022 | 2022 | INSTITUTE FOR SYSTEMS BIOLOGY | 401 TERRY AVE N | SEATTLE | WA | 98109-5263 | KING | USA | R21GM140391 | PRODIGE: A high-throughput tool for joint profiling of protein-DNA interactions and gene expression in single cells | 000 | 2 | NIH | 8/9/2022 | $228,750 |
| | 2022 | 2022 | INSTITUTE FOR SYSTEMS BIOLOGY | 401 TERRY AVE N | SEATTLE | WA | 98109-5263 | KING | USA | R01CA264090 | Nano and biomolecular engineered technologies for neoantigen-specific T cell capture and characterization | 000 | 2 | NIH | 7/29/2022 | $547,911 |
| | 2022 | 2022 | INSTITUTE FOR SYSTEMS BIOLOGY | 401 TERRY AVE N | SEATTLE | WA | 98109-5263 | KING | USA | R01AI163131 | NLRP3 inflammasome activation and its crosstalk with RLR signaling at the mitochondria | 000 | 2 | NIH | 5/23/2022 | $457,500 |
| | 2022 | 2022 | INSTITUTE FOR SYSTEMS BIOLOGY | 401 TERRY AVE N | SEATTLE | WA | 98109-5263 | KING | USA | OT2TR003450 | EVIDARA: Automated Evidential Support from Raw Data for relay agents in Biomedical KG Queries | 001 | 1 | NIH | 1/28/2022 | $532,891 |
| | 2022 | 2022 | INSTITUTE FOR SYSTEMS BIOLOGY | 401 TERRY AVE N | SEATTLE | WA | 98109-5263 | KING | USA | R21AI149171 | Does post-transcriptional control of NLRP3 inflammasome activity impact development of type 1 diabetes? | 000 | 2 | NIH | 5/17/2022 | $247,044 |
| | 2022 | 2022 | INSTITUTE FOR SYSTEMS BIOLOGY | 401 TERRY AVE N | SEATTLE | WA | 98109-5263 | KING | USA | OT2TR003443 | DOCKET: accelerating knowledge extraction from biomedical data sets | 001 | 1 | NIH | 1/29/2022 | $609,144 |
| | 2022 | 2022 | INSTITUTE FOR SYSTEMS BIOLOGY | 401 TERRY AVE N | SEATTLE | WA | 98109-5263 | KING | USA | R01AI148489 | Elucidating the role of TSR glycosylation in Plasmodium parasites | 000 | 3 | NIH | 5/17/2022 | $844,019 |
| | 2022 | 2022 | INSTITUTE FOR SYSTEMS BIOLOGY | 401 TERRY AVE N | SEATTLE | WA | 98109-5263 | KING | USA | R01GM136974 | The Expedit-Isotopomeric CrossLinking Mass Spectrometry (Expedit-ICLMS) technology for mapping global and dynamic protein-protein interaction networks | 001 | 3 | NIH | 6/29/2022 | $49,299 |
| | 2022 | 2022 | INSTITUTE FOR SYSTEMS BIOLOGY | 401 TERRY AVE N | SEATTLE | WA | 98109-5263 | KING | USA | R01GM136974 | The Expedit-Isotopomeric CrossLinking Mass Spectrometry (Expedit-ICLMS) technology for mapping global and dynamic protein-protein interaction networks | 000 | 3 | NIH | 3/23/2022 | $443,668 |
| | 2022 | 2022 | INSTITUTE FOR SYSTEMS BIOLOGY | 401 TERRY AVE N | SEATTLE | WA | 98109-5263 | KING | USA | R01GM135396 | Theory and Measurement of Cell Population Dynamics with Cell-Cell Interaction (TMCC) | 000 | 4 | NIH | 7/14/2022 | $419,895 |
| | 2022 | 2022 | INSTITUTE FOR SYSTEMS BIOLOGY | 401 TERRY AVE N | SEATTLE | WA | 98109-5263 | KING | USA | R01AI141953 | A systems approach to manipulate microbial adaptation to structured environments | 002 | 4 | NIH | 5/25/2022 | $869,107 |
| | 2022 | 2022 | INSTITUTE FOR SYSTEMS BIOLOGY | 401 TERRY AVE N | SEATTLE | WA | 98109-5263 | KING | USA | R01AI155685 | Host innate immune mechanisms control temporal expression of flagellin by pathogenic Salmonella | 000 | 2 | NIH | 6/3/2022 | $543,982 |
| | 2022 | 2022 | INSTITUTE FOR SYSTEMS BIOLOGY | 401 TERRY AVE N | SEATTLE | WA | 98109-5263 | KING | USA | U24HG010136 | Dfam: sustainable growth, curation support, and improved quality for mobile element annotation | 000 | 5 | NIH | 5/27/2022 | $600,717 |
| | 2022 | 2022 | INSTITUTE FOR SYSTEMS BIOLOGY | 401 TERRY AVE N | SEATTLE | WA | 98109-5263 | KING | USA | F32CA247445 | A systems approach to understanding overall drug response in a heterogeneous tumor-cell population | 001 | 3 | NIH | 6/13/2022 | $1,312 |
| | 2022 | 2022 | INSTITUTE FOR SYSTEMS BIOLOGY | 401 TERRY AVE N | SEATTLE | WA | 98109-5263 | KING | USA | F32CA247445 | A systems approach to understanding overall drug response in a heterogeneous tumor-cell population | 000 | 3 | NIH | 2/10/2022 | $72,630 |
| | 2022 | 2022 | INSTITUTE FOR SYSTEMS BIOLOGY | 401 TERRY AVE N | SEATTLE | WA | 98109-5263 | KING | USA | R01AI128215 | A systems analysis of drug tolerance in Mycobacterium tuberculosis | 001 | 6 | NIH | 6/28/2022 | $904,421 |
| | 2022 | 2022 | INSTITUTE FOR SYSTEMS BIOLOGY | 401 TERRY AVE N | SEATTLE | WA | 98109-5263 | KING | USA | R01DK098449 | Transcriptional Control During Erythropoiesis | 000 | 8 | NIH | 5/4/2022 | $619,838 |
| | 2022 | 2022 | INSTITUTE FOR SYSTEMS BIOLOGY | 401 TERRY AVE N | SEATTLE | WA | 98109-5263 | KING | USA | R01DK133468 | CyberGut: towards personalized human-microbiome metabolic modeling for precision health and nutrition | 000 | 1 | NIH | 6/27/2022 | $718,725 |
| | 2022 | 2022 | INSTITUTE FOR SYSTEMS BIOLOGY | 401 TERRY AVE N | SEATTLE | WA | 98109-5263 | KING | USA | R01HG002939 | Development and Maintenance of RepeatMasker and RepeatModeler | 000 | 16 | NIH | 2/4/2022 | $532,405 |
| | 2022 | 2021 | INSTITUTE FOR SYSTEMS BIOLOGY | 401 TERRY AVE N | SEATTLE | WA | 98109-5263 | KING | USA | R01AI141953 | A systems approach to manipulate microbial adaptation to structured environments | 001 | 3 | NIH | 5/4/2022 | $0 |
| | 2022 | 2021 | INSTITUTE FOR SYSTEMS BIOLOGY | 401 TERRY AVE N | SEATTLE | WA | 98109-5263 | KING | USA | R01AI141953 | A systems approach to manipulate microbial adaptation to structured environments | 000 | 3 | NIH | 5/4/2022 | $0 |
| | 2022 | 2021 | INSTITUTE FOR SYSTEMS BIOLOGY | 401 TERRY AVE N | SEATTLE | WA | 98109-5263 | KING | USA | U01CA217655 | Steady states and cellular transitions associated with carcinogenesis and tumorprogression | 000 | 6 | NIH | 4/29/2022 | $0 |
| | 2022 | 2021 | INSTITUTE FOR SYSTEMS BIOLOGY | 401 TERRY AVE N | SEATTLE | WA | 98109-5263 | KING | USA | U01CA217655 | Steady states and cellular transitions associated with carcinogenesis and tumorprogression | 001 | 6 | NIH | 5/4/2022 | $0 |
| | 2022 | 2021 | INSTITUTE FOR SYSTEMS BIOLOGY | 401 TERRY AVE N | SEATTLE | WA | 98109-5263 | KING | USA | R01AI128215 | A systems analysis of drug tolerance in Mycobacterium tuberculosis | 000 | 5 | NIH | 6/17/2022 | $0 |
| | 2022 | 2021 | INSTITUTE FOR SYSTEMS BIOLOGY | 401 TERRY AVE N | SEATTLE | WA | 98109-5263 | KING | USA | R01CA255536 | Instability of Cancer Cell States in Tumor progression (ICCS) | 000 | 1 | NIH | 3/31/2022 | $0 |
| | 2022 | 2020 | INSTITUTE FOR SYSTEMS BIOLOGY | 401 TERRY AVE N | SEATTLE | WA | 98109-5263 | KING | USA | OT2TR003443 | DOCKET: accelerating knowledge extraction from biomedical data sets | 000 | 1 | NIH | 1/27/2022 | $0 |
| | 2022 | 2020 | INSTITUTE FOR SYSTEMS BIOLOGY | 401 TERRY AVE N | SEATTLE | WA | 98109-5263 | KING | USA | R21AI142302 | Proteogenomic resource for the development of novel markers for Lyme disease | 000 | 2 | NIH | 10/27/2021 | $0 |
| | 2022 | 2020 | INSTITUTE FOR SYSTEMS BIOLOGY | 401 TERRY AVE N | SEATTLE | WA | 98109-5263 | KING | USA | U54CA199090 | Repurposing of cancer therapeutics for treatment of patients with COVID-19 disease | 000 | 6 | NIH | 12/15/2021 | -$70,602 |
| | 2022 | 2020 | INSTITUTE FOR SYSTEMS BIOLOGY | 401 TERRY AVE N | SEATTLE | WA | 98109-5263 | KING | USA | R01HG002939 | Development and Maintenance of RepeatMasker and RepeatModeler | 001 | 15 | NIH | 5/3/2022 | -$1,588 |
| | 2022 | 2020 | INSTITUTE FOR SYSTEMS BIOLOGY | 401 TERRY AVE N | SEATTLE | WA | 98109-5263 | KING | USA | OT2TR003450 | EVIDARA: Automated Evidential Support from Raw Data for relay agents in Biomedical KG Queries | 000 | 1 | NIH | 1/27/2022 | $0 |
| | 2022 | 2019 | INSTITUTE FOR SYSTEMS BIOLOGY | 401 TERRY AVE N | SEATTLE | WA | 98109-5263 | KING | USA | R24GM127667 | Advancing data and metadata standards for proteomics mass spectra | 000 | 3 | NIH | 4/22/2022 | -$2 |
| | 2022 | 2019 | INSTITUTE FOR SYSTEMS BIOLOGY | 401 TERRY AVE N | SEATTLE | WA | 98109-5263 | KING | USA | R01HL133678 | An LXR protein interaction network controlling macrophage lipid transporter expression in response to inflammatory-lipid crosstalk | 000 | 4 | NIH | 11/26/2021 | -$1,348 |
| | 2022 | 2019 | INSTITUTE FOR SYSTEMS BIOLOGY | 401 TERRY AVE N | SEATTLE | WA | 98109-5263 | KING | USA | S10OD026936 | Acquisition of Fusion Lumos Orbitrap mass spectrometer | 000 | 1 | NIH | 2/16/2022 | $0 |
|
| Issue Date FY: 2021 ( Subtotal = $10,411,312 ) (Continued on the next page) |
| | 2021 | 2021 | INSTITUTE FOR SYSTEMS BIOLOGY | 401 TERRY AVE N | SEATTLE | WA | 98109-5263 | KING | USA | R01CA264090 | Nano and biomolecular engineered technologies for neoantigen-specific T cell capture and characterization | 000 | 1 | NIH | 9/16/2021 | $595,609 |
| | 2021 | 2021 | INSTITUTE FOR SYSTEMS BIOLOGY | 401 TERRY AVE N | SEATTLE | WA | 98109-5263 | KING | USA | R01CA255536 | Instability of Cancer Cell States in Tumor progression (ICCS) | 000 | 1 | NIH | 9/21/2021 | $509,003 |
| | 2021 | 2021 | INSTITUTE FOR SYSTEMS BIOLOGY | 401 TERRY AVE N | SEATTLE | WA | 98109-5263 | KING | USA | R01AI163131 | NLRP3 inflammasome activation and its crosstalk with RLR signaling at the mitochondria | 000 | 1 | NIH | 6/15/2021 | $457,500 |
| | 2021 | 2021 | INSTITUTE FOR SYSTEMS BIOLOGY | 401 TERRY AVE N | SEATTLE | WA | 98109-5263 | KING | USA | OT2TR003450 | EVIDARA: Automated Evidential Support from Raw Data for relay agents in Biomedical KG Queries | 001 | 1 | NIH | 2/6/2021 | $437,326 |
| | 2021 | 2021 | INSTITUTE FOR SYSTEMS BIOLOGY | 401 TERRY AVE N | SEATTLE | WA | 98109-5263 | KING | USA | R21AI149171 | Does post-transcriptional control of NLRP3 inflammasome activity impact development of type 1 diabetes? | 000 | 1 | NIH | 5/11/2021 | $292,384 |
| | 2021 | 2021 | INSTITUTE FOR SYSTEMS BIOLOGY | 401 TERRY AVE N | SEATTLE | WA | 98109-5263 | KING | USA | OT2TR003443 | DOCKET: accelerating knowledge extraction from biomedical data sets | 003 | 1 | NIH | 8/18/2021 | $343,788 |
| | 2021 | 2021 | INSTITUTE FOR SYSTEMS BIOLOGY | 401 TERRY AVE N | SEATTLE | WA | 98109-5263 | KING | USA | OT2TR003443 | DOCKET: accelerating knowledge extraction from biomedical data sets | 001 | 1 | NIH | 2/9/2021 | $332,969 |
| | 2021 | 2021 | INSTITUTE FOR SYSTEMS BIOLOGY | 401 TERRY AVE N | SEATTLE | WA | 98109-5263 | KING | USA | R01AI148489 | Elucidating the role of TSR glycosylation in Plasmodium parasites | 000 | 2 | NIH | 5/12/2021 | $844,019 |
| | 2021 | 2021 | INSTITUTE FOR SYSTEMS BIOLOGY | 401 TERRY AVE N | SEATTLE | WA | 98109-5263 | KING | USA | R01GM136974 | The Expedit-Isotopomeric CrossLinking Mass Spectrometry (Expedit-ICLMS) technology for mapping global and dynamic protein-protein interaction networks | 000 | 2 | NIH | 3/24/2021 | $492,967 |
| | 2021 | 2021 | INSTITUTE FOR SYSTEMS BIOLOGY | 401 TERRY AVE N | SEATTLE | WA | 98109-5263 | KING | USA | R01GM135396 | Theory and Measurement of Cell Population Dynamics with Cell-Cell Interaction (TMCC) | 000 | 3 | NIH | 6/30/2021 | $419,895 |
| | 2021 | 2021 | INSTITUTE FOR SYSTEMS BIOLOGY | 401 TERRY AVE N | SEATTLE | WA | 98109-5263 | KING | USA | R01AI141953 | A systems approach to manipulate microbial adaptation to structured environments | 002 | 3 | NIH | 6/11/2021 | $76,331 |
| | 2021 | 2021 | INSTITUTE FOR SYSTEMS BIOLOGY | 401 TERRY AVE N | SEATTLE | WA | 98109-5263 | KING | USA | R01AI141953 | A systems approach to manipulate microbial adaptation to structured environments | 001 | 3 | NIH | 6/10/2021 | $50,942 |
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