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 | Issue Date FY: 2025 ( Subtotal = $5,620,732 ) |
| | 2025 | 2025 | INSTITUTE FOR SYSTEMS BIOLOGY | 401 TERRY AVE N | SEATTLE | WA | 98109-5263 | KING | USA | R01CA270210 | Prototype System for AML Digital Twins | 000 | 3 | NIH | 1/8/2025 | $629,127 |
| | 2025 | 2025 | INSTITUTE FOR SYSTEMS BIOLOGY | 401 TERRY AVE N | SEATTLE | WA | 98109-5263 | KING | USA | R01HG002939 | Development and Maintenance of RepeatMasker and RepeatModeler | 000 | 19 | NIH | 4/9/2025 | $532,067 |
| | 2025 | 2025 | INSTITUTE FOR SYSTEMS BIOLOGY | 401 TERRY AVE N | SEATTLE | WA | 98109-5263 | KING | USA | R35GM150994 | Single-cell transcriptomics of complex bacterial communities | 000 | 3 | NIH | 6/13/2025 | $470,000 |
| | 2025 | 2025 | INSTITUTE FOR SYSTEMS BIOLOGY | 401 TERRY AVE N | SEATTLE | WA | 98109-5263 | KING | USA | R01AI183678 | Defining the immunogenic landscape of early mosquito-stage P. falciparum to accelerate malaria transmission-blocking vaccine discovery | 000 | 2 | NIH | 5/21/2025 | $947,948 |
| | 2025 | 2025 | INSTITUTE FOR SYSTEMS BIOLOGY | 401 TERRY AVE N | SEATTLE | WA | 98109-5263 | KING | USA | R01CA259469 | Systems biology of intratumoral heterogeneity in glioblastoma | 000 | 4 | NIH | 12/31/2024 | $664,580 |
| | 2025 | 2025 | INSTITUTE FOR SYSTEMS BIOLOGY | 401 TERRY AVE N | SEATTLE | WA | 98109-5263 | KING | USA | R03AI175977 | Modeling the dynamics and composition of T-cell receptor repertoires in post-acute sequelae of COVID-19 (PASC) | 000 | 2 | NIH | 11/6/2024 | $91,180 |
| | 2025 | 2025 | INSTITUTE FOR SYSTEMS BIOLOGY | 401 TERRY AVE N | SEATTLE | WA | 98109-5263 | KING | USA | R01HG002939 | Development and Maintenance of RepeatMasker and RepeatModeler | 001 | 19 | NIH | 4/25/2025 | $59,119 |
| | 2025 | 2025 | INSTITUTE FOR SYSTEMS BIOLOGY | 401 TERRY AVE N | SEATTLE | WA | 98109-5263 | KING | USA | R01AI163131 | NLRP3 inflammasome activation and its crosstalk with RLR signaling at the mitochondria | 000 | 5 | NIH | 5/28/2025 | $470,000 |
| | 2025 | 2025 | INSTITUTE FOR SYSTEMS BIOLOGY | 401 TERRY AVE N | SEATTLE | WA | 98109-5263 | KING | USA | R01CA296872 | RarecyteFinder: A Bench-to-Bits Toolkit for Label-Free, Whole-Spectrum Analysis of Rare Disseminated Tumor Cells in Liquid and Tissue Biopsies | 000 | 1 | NIH | 12/31/2024 | $554,653 |
| | 2025 | 2025 | INSTITUTE FOR SYSTEMS BIOLOGY | 401 TERRY AVE N | SEATTLE | WA | 98109-5263 | KING | USA | R01AI155685 | Host innate immune mechanisms control temporal expression of flagellin by pathogenic Salmonella | 000 | 5 | NIH | 6/4/2025 | $490,327 |
| | 2025 | 2025 | INSTITUTE FOR SYSTEMS BIOLOGY | 401 TERRY AVE N | SEATTLE | WA | 98109-5263 | KING | USA | R01DK133468 | CyberGut: towards personalized human-microbiome metabolic modeling for precision health and nutrition | 001 | 4 | NIH | 5/19/2025 | $508,627 |
| | 2025 | 2025 | INSTITUTE FOR SYSTEMS BIOLOGY | 401 TERRY AVE N | SEATTLE | WA | 98109-5263 | KING | USA | R00AG070102 | Development of a Predictive Frailty Clock & Longitudinal Investigation of its Epigenetic Determinants | 002 | 5 | NIH | 6/20/2025 | $19,920 |
| | 2025 | 2025 | INSTITUTE FOR SYSTEMS BIOLOGY | 401 TERRY AVE N | SEATTLE | WA | 98109-5263 | KING | USA | R00AG070102 | Development of a Predictive Frailty Clock & Longitudinal Investigation of its Epigenetic Determinants | 000 | 5 | NIH | 5/1/2025 | $224,100 |
| | 2025 | 2024 | INSTITUTE FOR SYSTEMS BIOLOGY | 401 TERRY AVE N | SEATTLE | WA | 98109-5263 | KING | USA | U54CA274509 | Spatiotemporal Tumor Analytics for Guiding Sequential Targeted-Inhibitor: Immunotherapy Combinations (ST-Analytics) | 000 | 3 | NIH | 10/11/2024 | $0 |
| | 2025 | 2024 | INSTITUTE FOR SYSTEMS BIOLOGY | 401 TERRY AVE N | SEATTLE | WA | 98109-5263 | KING | USA | OT2TR003450 | EVIDARA: Automated Evidential Support from Raw Data for relay agents in Biomedical KG Queries | 002 | 1 | NIH | 5/13/2025 | $0 |
| | 2025 | 2024 | INSTITUTE FOR SYSTEMS BIOLOGY | 401 TERRY AVE N | SEATTLE | WA | 98109-5263 | KING | USA | OT2TR003450 | EVIDARA: Automated Evidential Support from Raw Data for relay agents in Biomedical KG Queries | 001 | 1 | NIH | 11/29/2024 | $0 |
| | 2025 | 2024 | INSTITUTE FOR SYSTEMS BIOLOGY | 401 TERRY AVE N | SEATTLE | WA | 98109-5263 | KING | USA | R01DK133468 | CyberGut: towards personalized human-microbiome metabolic modeling for precision health and nutrition | 000 | 3 | NIH | 4/29/2025 | $8,505 |
| | 2025 | 2024 | INSTITUTE FOR SYSTEMS BIOLOGY | 401 TERRY AVE N | SEATTLE | WA | 98109-5263 | KING | USA | R01CA255536 | Instability of Cancer Cell States in Tumor progression (ICCS) | 000 | 4 | NIH | 10/11/2024 | $8,397 |
| | 2025 | 2024 | INSTITUTE FOR SYSTEMS BIOLOGY | 401 TERRY AVE N | SEATTLE | WA | 98109-5263 | KING | USA | R01CA255536 | Instability of Cancer Cell States in Tumor progression (ICCS) | 001 | 4 | NIH | 10/24/2024 | -$8,397 |
| | 2025 | 2024 | INSTITUTE FOR SYSTEMS BIOLOGY | 401 TERRY AVE N | SEATTLE | WA | 98109-5263 | KING | USA | R00AG070102 | Development of a Predictive Frailty Clock & Longitudinal Investigation of its Epigenetic Determinants | 001 | 4 | NIH | 5/14/2025 | $0 |
| | 2025 | 2024 | INSTITUTE FOR SYSTEMS BIOLOGY | 401 TERRY AVE N | SEATTLE | WA | 98109-5263 | KING | USA | OT2TR003443 | DOCKET: accelerating knowledge extraction from biomedical data sets | 000 | 1 | NIH | 4/1/2025 | $0 |
| | 2025 | 2024 | INSTITUTE FOR SYSTEMS BIOLOGY | 401 TERRY AVE N | SEATTLE | WA | 98109-5263 | KING | USA | U54CA274509 | Spatiotemporal Tumor Analytics for Guiding Sequential Targeted-Inhibitor: Immunotherapy Combinations (ST-Analytics) | 001 | 3 | NIH | 5/12/2025 | $0 |
| | 2025 | 2023 | INSTITUTE FOR SYSTEMS BIOLOGY | 401 TERRY AVE N | SEATTLE | WA | 98109-5263 | KING | USA | R01GM136974 | The Expedit-Isotopomeric CrossLinking Mass Spectrometry (Expedit-ICLMS) technology for mapping global and dynamic protein-protein interaction networks | 000 | 4 | NIH | 5/12/2025 | -$10 |
| | 2025 | 2022 | INSTITUTE FOR SYSTEMS BIOLOGY | 401 TERRY AVE N | SEATTLE | WA | 98109-5263 | KING | USA | R21AI149171 | Does post-transcriptional control of NLRP3 inflammasome activity impact development of type 1 diabetes? | 000 | 2 | NIH | 11/22/2024 | -$2,651 |
| | 2025 | 2022 | INSTITUTE FOR SYSTEMS BIOLOGY | 401 TERRY AVE N | SEATTLE | WA | 98109-5263 | KING | USA | R01GM135396 | Theory and Measurement of Cell Population Dynamics with Cell-Cell Interaction (TMCC) | 000 | 4 | NIH | 1/23/2025 | -$484 |
| | 2025 | 2022 | INSTITUTE FOR SYSTEMS BIOLOGY | 401 TERRY AVE N | SEATTLE | WA | 98109-5263 | KING | USA | R21GM140391 | PRODIGE: A high-throughput tool for joint profiling of protein-DNA interactions and gene expression in single cells | 000 | 2 | NIH | 4/2/2025 | -$632 |
| | 2025 | 2021 | INSTITUTE FOR SYSTEMS BIOLOGY | 401 TERRY AVE N | SEATTLE | WA | 98109-5263 | KING | USA | R01AI141953 | Site Specific Immunophenotyping Assays of COVID19 Patients to Align with NIAID National Study | 000 | 3 | NIH | 10/24/2024 | -$45,643 |
| | 2025 | 2020 | INSTITUTE FOR SYSTEMS BIOLOGY | 401 TERRY AVE N | SEATTLE | WA | 98109-5263 | KING | USA | OT2TR003450 | EVIDARA: Automated Evidential Support from Raw Data for relay agents in Biomedical KG Queries | 000 | 1 | NIH | 11/29/2024 | $0 |
|
| Issue Date FY: 2024 ( Subtotal = $13,945,146 ) (Continued on the next page) |
| | 2024 | 2024 | INSTITUTE FOR SYSTEMS BIOLOGY | 401 TERRY AVE N | SEATTLE | WA | 98109-5263 | KING | USA | U24HG010136 | Dfam: sustainable growth, curation support, and improved quality for mobile element annotation | 004 | 7 | NIH | 9/24/2024 | $0 |
| | 2024 | 2024 | INSTITUTE FOR SYSTEMS BIOLOGY | 401 TERRY AVE N | SEATTLE | WA | 98109-5263 | KING | USA | R35GM150994 | Single-cell transcriptomics of complex bacterial communities | 001 | 2 | NIH | 7/18/2024 | $185,871 |
| | 2024 | 2024 | INSTITUTE FOR SYSTEMS BIOLOGY | 401 TERRY AVE N | SEATTLE | WA | 98109-5263 | KING | USA | R35GM150994 | Single-cell transcriptomics of complex bacterial communities | 000 | 2 | NIH | 7/10/2024 | $470,000 |
| | 2024 | 2024 | INSTITUTE FOR SYSTEMS BIOLOGY | 401 TERRY AVE N | SEATTLE | WA | 98109-5263 | KING | USA | U54CA274509 | Spatiotemporal Tumor Analytics for Guiding Sequential Targeted-Inhibitor: Immunotherapy Combinations (ST-Analytics) | 003 | 3 | NIH | 9/12/2024 | $133,520 |
| | 2024 | 2024 | INSTITUTE FOR SYSTEMS BIOLOGY | 401 TERRY AVE N | SEATTLE | WA | 98109-5263 | KING | USA | U54CA274509 | Spatiotemporal Tumor Analytics for Guiding Sequential Targeted-Inhibitor: Immunotherapy Combinations (ST-Analytics) | 001 | 2 | NIH | 8/16/2024 | $12,350 |
| | 2024 | 2024 | INSTITUTE FOR SYSTEMS BIOLOGY | 401 TERRY AVE N | SEATTLE | WA | 98109-5263 | KING | USA | U54CA274509 | Spatiotemporal Tumor Analytics for Guiding Sequential Targeted-Inhibitor: Immunotherapy Combinations (ST-Analytics) | 002 | 3 | NIH | 9/10/2024 | $2,342,452 |
| | 2024 | 2024 | INSTITUTE FOR SYSTEMS BIOLOGY | 401 TERRY AVE N | SEATTLE | WA | 98109-5263 | KING | USA | K99HD112600 | Enhancing personalized insights into common obstetric disorders using longitudinal deep-phenotyping data | 000 | 2 | NIH | 8/12/2024 | $142,830 |
| | 2024 | 2024 | INSTITUTE FOR SYSTEMS BIOLOGY | 401 TERRY AVE N | SEATTLE | WA | 98109-5263 | KING | USA | R01CA270210 | Prototype System for AML Digital Twins | 002 | 2 | NIH | 7/10/2024 | $0 |
| | 2024 | 2024 | INSTITUTE FOR SYSTEMS BIOLOGY | 401 TERRY AVE N | SEATTLE | WA | 98109-5263 | KING | USA | R01CA270210 | Prototype System for AML Digital Twins | 001 | 2 | NIH | 4/16/2024 | $35,066 |
| | 2024 | 2024 | INSTITUTE FOR SYSTEMS BIOLOGY | 401 TERRY AVE N | SEATTLE | WA | 98109-5263 | KING | USA | R01CA270210 | Prototype System for AML Digital Twins | 000 | 2 | NIH | 11/30/2023 | $631,158 |
| | 2024 | 2024 | INSTITUTE FOR SYSTEMS BIOLOGY | 401 TERRY AVE N | SEATTLE | WA | 98109-5263 | KING | USA | R01CA264090 | Nano and biomolecular engineered technologies for neoantigen-specific T cell capture and characterization | 000 | 4 | NIH | 6/19/2024 | $509,788 |
| | 2024 | 2024 | INSTITUTE FOR SYSTEMS BIOLOGY | 401 TERRY AVE N | SEATTLE | WA | 98109-5263 | KING | USA | R21HD112819 | Enhancing insight into placental dysfunction in common obstetric disorders using placental multiomics | 000 | 1 | NIH | 7/10/2024 | $293,756 |
| | 2024 | 2024 | INSTITUTE FOR SYSTEMS BIOLOGY | 401 TERRY AVE N | SEATTLE | WA | 98109-5263 | KING | USA | R01HG002939 | Development and Maintenance of RepeatMasker and RepeatModeler | 001 | 18 | NIH | 7/11/2024 | $47,055 |
| | 2024 | 2024 | INSTITUTE FOR SYSTEMS BIOLOGY | 401 TERRY AVE N | SEATTLE | WA | 98109-5263 | KING | USA | R01HG002939 | Development and Maintenance of RepeatMasker and RepeatModeler | 000 | 18 | NIH | 2/22/2024 | $529,357 |
| | 2024 | 2024 | INSTITUTE FOR SYSTEMS BIOLOGY | 401 TERRY AVE N | SEATTLE | WA | 98109-5263 | KING | USA | R01AI183678 | Defining the immunogenic landscape of early mosquito-stage P. falciparum to accelerate malaria transmission-blocking vaccine discovery | 000 | 1 | NIH | 7/5/2024 | $875,155 |
| | 2024 | 2024 | INSTITUTE FOR SYSTEMS BIOLOGY | 401 TERRY AVE N | SEATTLE | WA | 98109-5263 | KING | USA | R01AI183678 | Defining the immunogenic landscape of early mosquito-stage P. falciparum to accelerate malaria transmission-blocking vaccine discovery | 001 | 1 | NIH | 9/4/2024 | $94,793 |
| | 2024 | 2024 | INSTITUTE FOR SYSTEMS BIOLOGY | 401 TERRY AVE N | SEATTLE | WA | 98109-5263 | KING | USA | R01AI163131 | NLRP3 inflammasome activation and its crosstalk with RLR signaling at the mitochondria | 000 | 4 | NIH | 5/14/2024 | $470,000 |
| | 2024 | 2024 | INSTITUTE FOR SYSTEMS BIOLOGY | 401 TERRY AVE N | SEATTLE | WA | 98109-5263 | KING | USA | R01AI148489 | Elucidating the role of TSR glycosylation in Plasmodium parasites | 001 | 5 | NIH | 7/18/2024 | $0 |
| | 2024 | 2024 | INSTITUTE FOR SYSTEMS BIOLOGY | 401 TERRY AVE N | SEATTLE | WA | 98109-5263 | KING | USA | R01AI148489 | Elucidating the role of TSR glycosylation in Plasmodium parasites | 000 | 5 | NIH | 5/17/2024 | $818,591 |
| | 2024 | 2024 | INSTITUTE FOR SYSTEMS BIOLOGY | 401 TERRY AVE N | SEATTLE | WA | 98109-5263 | KING | USA | OT2TR003450 | EVIDARA: Automated Evidential Support from Raw Data for relay agents in Biomedical KG Queries | 002 | 1 | NIH | 2/16/2024 | $0 |
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