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| | |
 | Issue Date FY: 2025 ( Subtotal = $45,537 ) |
| | 2025 | 2025 | INSTITUTE FOR SYSTEMS BIOLOGY | 401 TERRY AVE N | SEATTLE | WA | 98109-5263 | KING | USA | R03AI175977 | Modeling the dynamics and composition of T-cell receptor repertoires in post-acute sequelae of COVID-19 (PASC) | 000 | 2 | NIH | 11/6/2024 | $91,180 |
| | 2025 | 2024 | INSTITUTE FOR SYSTEMS BIOLOGY | 401 TERRY AVE N | SEATTLE | WA | 98109-5263 | KING | USA | R01CA255536 | Instability of Cancer Cell States in Tumor progression (ICCS) | 001 | 4 | NIH | 10/24/2024 | -$8,397 |
| | 2025 | 2024 | INSTITUTE FOR SYSTEMS BIOLOGY | 401 TERRY AVE N | SEATTLE | WA | 98109-5263 | KING | USA | U54CA274509 | Spatiotemporal Tumor Analytics for Guiding Sequential Targeted-Inhibitor: Immunotherapy Combinations (ST-Analytics) | 000 | 3 | NIH | 10/11/2024 | $0 |
| | 2025 | 2024 | INSTITUTE FOR SYSTEMS BIOLOGY | 401 TERRY AVE N | SEATTLE | WA | 98109-5263 | KING | USA | R01CA255536 | Instability of Cancer Cell States in Tumor progression (ICCS) | 000 | 4 | NIH | 10/11/2024 | $8,397 |
| | 2025 | 2021 | INSTITUTE FOR SYSTEMS BIOLOGY | 401 TERRY AVE N | SEATTLE | WA | 98109-5263 | KING | USA | R01AI141953 | Site Specific Immunophenotyping Assays of COVID19 Patients to Align with NIAID National Study | 000 | 3 | NIH | 10/24/2024 | -$45,643 |
|
| Issue Date FY: 2024 ( Subtotal = $13,945,146 ) (Continued on the next page) |
| | 2024 | 2024 | INSTITUTE FOR SYSTEMS BIOLOGY | 401 TERRY AVE N | SEATTLE | WA | 98109-5263 | KING | USA | OT2TR003443 | DOCKET: accelerating knowledge extraction from biomedical data sets | 001 | 1 | NIH | 12/5/2023 | $609,144 |
| | 2024 | 2024 | INSTITUTE FOR SYSTEMS BIOLOGY | 401 TERRY AVE N | SEATTLE | WA | 98109-5263 | KING | USA | R03AI175977 | Modeling the dynamics and composition of T-cell receptor repertoires in post-acute sequelae of COVID-19 (PASC) | 001 | 1 | NIH | 9/11/2024 | $10,376 |
| | 2024 | 2024 | INSTITUTE FOR SYSTEMS BIOLOGY | 401 TERRY AVE N | SEATTLE | WA | 98109-5263 | KING | USA | R03AI175977 | Modeling the dynamics and composition of T-cell receptor repertoires in post-acute sequelae of COVID-19 (PASC) | 000 | 1 | NIH | 12/18/2023 | $93,386 |
| | 2024 | 2024 | INSTITUTE FOR SYSTEMS BIOLOGY | 401 TERRY AVE N | SEATTLE | WA | 98109-5263 | KING | USA | R01AI155685 | Host innate immune mechanisms control temporal expression of flagellin by pathogenic Salmonella | 000 | 4 | NIH | 5/7/2024 | $490,327 |
| | 2024 | 2024 | INSTITUTE FOR SYSTEMS BIOLOGY | 401 TERRY AVE N | SEATTLE | WA | 98109-5263 | KING | USA | R01HG002939 | Development and Maintenance of RepeatMasker and RepeatModeler | 000 | 18 | NIH | 2/22/2024 | $529,357 |
| | 2024 | 2024 | INSTITUTE FOR SYSTEMS BIOLOGY | 401 TERRY AVE N | SEATTLE | WA | 98109-5263 | KING | USA | R01CA270210 | Prototype System for AML Digital Twins | 001 | 2 | NIH | 4/16/2024 | $35,066 |
| | 2024 | 2024 | INSTITUTE FOR SYSTEMS BIOLOGY | 401 TERRY AVE N | SEATTLE | WA | 98109-5263 | KING | USA | U54CA274509 | Spatiotemporal Tumor Analytics for Guiding Sequential Targeted-Inhibitor: Immunotherapy Combinations (ST-Analytics) | 002 | 3 | NIH | 9/10/2024 | $2,342,452 |
| | 2024 | 2024 | INSTITUTE FOR SYSTEMS BIOLOGY | 401 TERRY AVE N | SEATTLE | WA | 98109-5263 | KING | USA | R01CA270210 | Prototype System for AML Digital Twins | 002 | 2 | NIH | 7/10/2024 | $0 |
| | 2024 | 2024 | INSTITUTE FOR SYSTEMS BIOLOGY | 401 TERRY AVE N | SEATTLE | WA | 98109-5263 | KING | USA | U54CA274509 | Spatiotemporal Tumor Analytics for Guiding Sequential Targeted-Inhibitor: Immunotherapy Combinations (ST-Analytics) | 003 | 3 | NIH | 9/12/2024 | $133,520 |
| | 2024 | 2024 | INSTITUTE FOR SYSTEMS BIOLOGY | 401 TERRY AVE N | SEATTLE | WA | 98109-5263 | KING | USA | R01HG002939 | Development and Maintenance of RepeatMasker and RepeatModeler | 001 | 18 | NIH | 7/11/2024 | $47,055 |
| | 2024 | 2024 | INSTITUTE FOR SYSTEMS BIOLOGY | 401 TERRY AVE N | SEATTLE | WA | 98109-5263 | KING | USA | U54CA274509 | Spatiotemporal Tumor Analytics for Guiding Sequential Targeted-Inhibitor: Immunotherapy Combinations (ST-Analytics) | 001 | 2 | NIH | 8/16/2024 | $12,350 |
| | 2024 | 2024 | INSTITUTE FOR SYSTEMS BIOLOGY | 401 TERRY AVE N | SEATTLE | WA | 98109-5263 | KING | USA | R01AI183678 | Defining the immunogenic landscape of early mosquito-stage P. falciparum to accelerate malaria transmission-blocking vaccine discovery | 001 | 1 | NIH | 9/4/2024 | $94,793 |
| | 2024 | 2024 | INSTITUTE FOR SYSTEMS BIOLOGY | 401 TERRY AVE N | SEATTLE | WA | 98109-5263 | KING | USA | R01CA270210 | Prototype System for AML Digital Twins | 000 | 2 | NIH | 11/30/2023 | $631,158 |
| | 2024 | 2024 | INSTITUTE FOR SYSTEMS BIOLOGY | 401 TERRY AVE N | SEATTLE | WA | 98109-5263 | KING | USA | OT2TR003450 | EVIDARA: Automated Evidential Support from Raw Data for relay agents in Biomedical KG Queries | 002 | 1 | NIH | 2/16/2024 | $0 |
| | 2024 | 2024 | INSTITUTE FOR SYSTEMS BIOLOGY | 401 TERRY AVE N | SEATTLE | WA | 98109-5263 | KING | USA | OT2TR003450 | EVIDARA: Automated Evidential Support from Raw Data for relay agents in Biomedical KG Queries | 001 | 1 | NIH | 12/8/2023 | $543,957 |
| | 2024 | 2024 | INSTITUTE FOR SYSTEMS BIOLOGY | 401 TERRY AVE N | SEATTLE | WA | 98109-5263 | KING | USA | R01AI128215 | A systems analysis of drug tolerance in Mycobacterium tuberculosis | 002 | 8 | NIH | 7/2/2024 | $868,716 |
| | 2024 | 2024 | INSTITUTE FOR SYSTEMS BIOLOGY | 401 TERRY AVE N | SEATTLE | WA | 98109-5263 | KING | USA | R01AI183678 | Defining the immunogenic landscape of early mosquito-stage P. falciparum to accelerate malaria transmission-blocking vaccine discovery | 000 | 1 | NIH | 7/5/2024 | $875,155 |
| | 2024 | 2024 | INSTITUTE FOR SYSTEMS BIOLOGY | 401 TERRY AVE N | SEATTLE | WA | 98109-5263 | KING | USA | U24HG010136 | Dfam: sustainable growth, curation support, and improved quality for mobile element annotation | 004 | 7 | NIH | 9/24/2024 | $0 |
| | 2024 | 2024 | INSTITUTE FOR SYSTEMS BIOLOGY | 401 TERRY AVE N | SEATTLE | WA | 98109-5263 | KING | USA | R21AI178424 | A non-canonical role of Caspase-1 in regulating bacterial antimicrobial resistance | 000 | 1 | NIH | 8/27/2024 | $282,000 |
| | 2024 | 2024 | INSTITUTE FOR SYSTEMS BIOLOGY | 401 TERRY AVE N | SEATTLE | WA | 98109-5263 | KING | USA | R01AI148489 | Elucidating the role of TSR glycosylation in Plasmodium parasites | 001 | 5 | NIH | 7/18/2024 | $0 |
| | 2024 | 2024 | INSTITUTE FOR SYSTEMS BIOLOGY | 401 TERRY AVE N | SEATTLE | WA | 98109-5263 | KING | USA | R35GM150994 | Single-cell transcriptomics of complex bacterial communities | 001 | 2 | NIH | 7/18/2024 | $185,871 |
| | 2024 | 2024 | INSTITUTE FOR SYSTEMS BIOLOGY | 401 TERRY AVE N | SEATTLE | WA | 98109-5263 | KING | USA | R35GM150994 | Single-cell transcriptomics of complex bacterial communities | 000 | 2 | NIH | 7/10/2024 | $470,000 |
| | 2024 | 2024 | INSTITUTE FOR SYSTEMS BIOLOGY | 401 TERRY AVE N | SEATTLE | WA | 98109-5263 | KING | USA | R21HD112819 | Enhancing insight into placental dysfunction in common obstetric disorders using placental multiomics | 000 | 1 | NIH | 7/10/2024 | $293,756 |
| | 2024 | 2024 | INSTITUTE FOR SYSTEMS BIOLOGY | 401 TERRY AVE N | SEATTLE | WA | 98109-5263 | KING | USA | K99HD112600 | Enhancing personalized insights into common obstetric disorders using longitudinal deep-phenotyping data | 000 | 2 | NIH | 8/12/2024 | $142,830 |
| | 2024 | 2024 | INSTITUTE FOR SYSTEMS BIOLOGY | 401 TERRY AVE N | SEATTLE | WA | 98109-5263 | KING | USA | U24HG010136 | Dfam: sustainable growth, curation support, and improved quality for mobile element annotation | 003 | 7 | NIH | 8/5/2024 | $529,832 |
| | 2024 | 2024 | INSTITUTE FOR SYSTEMS BIOLOGY | 401 TERRY AVE N | SEATTLE | WA | 98109-5263 | KING | USA | R01CA255536 | Instability of Cancer Cell States in Tumor progression (ICCS) | 000 | 4 | NIH | 8/21/2024 | $474,027 |
| | 2024 | 2024 | INSTITUTE FOR SYSTEMS BIOLOGY | 401 TERRY AVE N | SEATTLE | WA | 98109-5263 | KING | USA | R01CA264090 | Nano and biomolecular engineered technologies for neoantigen-specific T cell capture and characterization | 000 | 4 | NIH | 6/19/2024 | $509,788 |
| | 2024 | 2024 | INSTITUTE FOR SYSTEMS BIOLOGY | 401 TERRY AVE N | SEATTLE | WA | 98109-5263 | KING | USA | OT2TR003443 | DOCKET: accelerating knowledge extraction from biomedical data sets | 003 | 1 | NIH | 6/18/2024 | $0 |
| | 2024 | 2024 | INSTITUTE FOR SYSTEMS BIOLOGY | 401 TERRY AVE N | SEATTLE | WA | 98109-5263 | KING | USA | R01DK133468 | CyberGut: towards personalized human-microbiome metabolic modeling for precision health and nutrition | 001 | 3 | NIH | 5/15/2024 | $64,004 |
| | 2024 | 2024 | INSTITUTE FOR SYSTEMS BIOLOGY | 401 TERRY AVE N | SEATTLE | WA | 98109-5263 | KING | USA | R01AI148489 | Elucidating the role of TSR glycosylation in Plasmodium parasites | 000 | 5 | NIH | 5/17/2024 | $818,591 |
| | 2024 | 2024 | INSTITUTE FOR SYSTEMS BIOLOGY | 401 TERRY AVE N | SEATTLE | WA | 98109-5263 | KING | USA | R01AI163131 | NLRP3 inflammasome activation and its crosstalk with RLR signaling at the mitochondria | 000 | 4 | NIH | 5/14/2024 | $470,000 |
| | 2024 | 2024 | INSTITUTE FOR SYSTEMS BIOLOGY | 401 TERRY AVE N | SEATTLE | WA | 98109-5263 | KING | USA | R01DK098449 | Transcriptional Control During Erythropoiesis | 001 | 10 | NIH | 5/8/2024 | $591,815 |
| | 2024 | 2024 | INSTITUTE FOR SYSTEMS BIOLOGY | 401 TERRY AVE N | SEATTLE | WA | 98109-5263 | KING | USA | R00AG070102 | Development of a Predictive Frailty Clock & Longitudinal Investigation of its Epigenetic Determinants | 002 | 4 | NIH | 5/2/2024 | $249,000 |
| | 2024 | 2024 | INSTITUTE FOR SYSTEMS BIOLOGY | 401 TERRY AVE N | SEATTLE | WA | 98109-5263 | KING | USA | R01CA259469 | Systems biology of intratumoral heterogeneity in glioblastoma | 001 | 3 | NIH | 4/16/2024 | $37,397 |
| | 2024 | 2024 | INSTITUTE FOR SYSTEMS BIOLOGY | 401 TERRY AVE N | SEATTLE | WA | 98109-5263 | KING | USA | R00AG070102 | Development of a Predictive Frailty Clock & Longitudinal Investigation of its Epigenetic Determinants | 003 | 4 | NIH | 5/6/2024 | $111,830 |
| | 2024 | 2024 | INSTITUTE FOR SYSTEMS BIOLOGY | 401 TERRY AVE N | SEATTLE | WA | 98109-5263 | KING | USA | R01DK133468 | CyberGut: towards personalized human-microbiome metabolic modeling for precision health and nutrition | 000 | 3 | NIH | 5/7/2024 | $666,308 |
| | 2024 | 2024 | INSTITUTE FOR SYSTEMS BIOLOGY | 401 TERRY AVE N | SEATTLE | WA | 98109-5263 | KING | USA | OT2TR003443 | DOCKET: accelerating knowledge extraction from biomedical data sets | 002 | 1 | NIH | 2/16/2024 | $0 |
| | 2024 | 2024 | INSTITUTE FOR SYSTEMS BIOLOGY | 401 TERRY AVE N | SEATTLE | WA | 98109-5263 | KING | USA | R01CA259469 | Systems biology of intratumoral heterogeneity in glioblastoma | 000 | 3 | NIH | 1/10/2024 | $673,173 |
| | 2024 | 2024 | INSTITUTE FOR SYSTEMS BIOLOGY | 401 TERRY AVE N | SEATTLE | WA | 98109-5263 | KING | USA | R00AG070102 | Development of a Predictive Frailty Clock & Longitudinal Investigation of its Epigenetic Determinants | 000 | 3 | NIH | 12/15/2023 | $37,277 |
| | 2024 | 2023 | INSTITUTE FOR SYSTEMS BIOLOGY | 401 TERRY AVE N | SEATTLE | WA | 98109-5263 | KING | USA | R01DK098449 | Transcriptional Control During Erythropoiesis | 000 | 9 | NIH | 5/7/2024 | $0 |
| | 2024 | 2023 | INSTITUTE FOR SYSTEMS BIOLOGY | 401 TERRY AVE N | SEATTLE | WA | 98109-5263 | KING | USA | U24HG010136 | Dfam: sustainable growth, curation support, and improved quality for mobile element annotation | 002 | 6 | NIH | 3/14/2024 | $352,593 |
| | 2024 | 2023 | INSTITUTE FOR SYSTEMS BIOLOGY | 401 TERRY AVE N | SEATTLE | WA | 98109-5263 | KING | USA | U24HG010136 | Dfam: sustainable growth, curation support, and improved quality for mobile element annotation | 000 | 6 | NIH | 11/29/2023 | $0 |
| | 2024 | 2023 | INSTITUTE FOR SYSTEMS BIOLOGY | 401 TERRY AVE N | SEATTLE | WA | 98109-5263 | KING | USA | R00AG070102 | Development of a Predictive Frailty Clock & Longitudinal Investigation of its Epigenetic Determinants | 001 | 3 | NIH | 12/20/2023 | $99,266 |
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