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 | Issue Date FY: 2024 ( Subtotal = $3,210,750 ) |
| | 2024 | 2024 | INSTITUTE FOR SYSTEMS BIOLOGY | 401 TERRY AVE N | SEATTLE | WA | 98109-5263 | KING | USA | R01CA259469 | Systems biology of intratumoral heterogeneity in glioblastoma | 000 | 3 | NIH | 1/10/2024 | $673,173 |
| | 2024 | 2024 | INSTITUTE FOR SYSTEMS BIOLOGY | 401 TERRY AVE N | SEATTLE | WA | 98109-5263 | KING | USA | R00AG070102 | Development of a Predictive Frailty Clock & Longitudinal Investigation of its Epigenetic Determinants | 000 | 3 | NIH | 12/15/2023 | $37,277 |
| | 2024 | 2024 | INSTITUTE FOR SYSTEMS BIOLOGY | 401 TERRY AVE N | SEATTLE | WA | 98109-5263 | KING | USA | R01CA270210 | Prototype System for AML Digital Twins | 001 | 2 | NIH | 4/16/2024 | $35,066 |
| | 2024 | 2024 | INSTITUTE FOR SYSTEMS BIOLOGY | 401 TERRY AVE N | SEATTLE | WA | 98109-5263 | KING | USA | R01CA270210 | Prototype System for AML Digital Twins | 000 | 2 | NIH | 11/30/2023 | $631,158 |
| | 2024 | 2024 | INSTITUTE FOR SYSTEMS BIOLOGY | 401 TERRY AVE N | SEATTLE | WA | 98109-5263 | KING | USA | R01CA259469 | Systems biology of intratumoral heterogeneity in glioblastoma | 001 | 3 | NIH | 4/16/2024 | $37,397 |
| | 2024 | 2024 | INSTITUTE FOR SYSTEMS BIOLOGY | 401 TERRY AVE N | SEATTLE | WA | 98109-5263 | KING | USA | R03AI175977 | Modeling the dynamics and composition of T-cell receptor repertoires in post-acute sequelae of COVID-19 (PASC) | 000 | 1 | NIH | 12/18/2023 | $93,386 |
| | 2024 | 2024 | INSTITUTE FOR SYSTEMS BIOLOGY | 401 TERRY AVE N | SEATTLE | WA | 98109-5263 | KING | USA | OT2TR003443 | DOCKET: accelerating knowledge extraction from biomedical data sets | 002 | 1 | NIH | 2/16/2024 | $0 |
| | 2024 | 2024 | INSTITUTE FOR SYSTEMS BIOLOGY | 401 TERRY AVE N | SEATTLE | WA | 98109-5263 | KING | USA | OT2TR003443 | DOCKET: accelerating knowledge extraction from biomedical data sets | 001 | 1 | NIH | 12/5/2023 | $609,144 |
| | 2024 | 2024 | INSTITUTE FOR SYSTEMS BIOLOGY | 401 TERRY AVE N | SEATTLE | WA | 98109-5263 | KING | USA | OT2TR003450 | EVIDARA: Automated Evidential Support from Raw Data for relay agents in Biomedical KG Queries | 002 | 1 | NIH | 2/16/2024 | $0 |
| | 2024 | 2024 | INSTITUTE FOR SYSTEMS BIOLOGY | 401 TERRY AVE N | SEATTLE | WA | 98109-5263 | KING | USA | OT2TR003450 | EVIDARA: Automated Evidential Support from Raw Data for relay agents in Biomedical KG Queries | 001 | 1 | NIH | 12/8/2023 | $543,957 |
| | 2024 | 2024 | INSTITUTE FOR SYSTEMS BIOLOGY | 401 TERRY AVE N | SEATTLE | WA | 98109-5263 | KING | USA | R01HG002939 | Development and Maintenance of RepeatMasker and RepeatModeler | 000 | 18 | NIH | 2/22/2024 | $529,357 |
| | 2024 | 2023 | INSTITUTE FOR SYSTEMS BIOLOGY | 401 TERRY AVE N | SEATTLE | WA | 98109-5263 | KING | USA | U24HG010136 | Dfam: sustainable growth, curation support, and improved quality for mobile element annotation | 002 | 6 | NIH | 3/14/2024 | $352,593 |
| | 2024 | 2023 | INSTITUTE FOR SYSTEMS BIOLOGY | 401 TERRY AVE N | SEATTLE | WA | 98109-5263 | KING | USA | U24HG010136 | Dfam: sustainable growth, curation support, and improved quality for mobile element annotation | 000 | 6 | NIH | 11/29/2023 | $0 |
| | 2024 | 2023 | INSTITUTE FOR SYSTEMS BIOLOGY | 401 TERRY AVE N | SEATTLE | WA | 98109-5263 | KING | USA | R00AG070102 | Development of a Predictive Frailty Clock & Longitudinal Investigation of its Epigenetic Determinants | 001 | 3 | NIH | 12/20/2023 | $99,266 |
| | 2024 | 2022 | INSTITUTE FOR SYSTEMS BIOLOGY | 401 TERRY AVE N | SEATTLE | WA | 98109-5263 | KING | USA | U24HG010136 | Dfam: sustainable growth, curation support, and improved quality for mobile element annotation | 001 | 5 | NIH | 3/14/2024 | -$352,593 |
| | 2024 | 2022 | INSTITUTE FOR SYSTEMS BIOLOGY | 401 TERRY AVE N | SEATTLE | WA | 98109-5263 | KING | USA | R01AI128215 | A systems analysis of drug tolerance in Mycobacterium tuberculosis | 001 | 6 | NIH | 2/7/2024 | $505,858 |
| | 2024 | 2022 | INSTITUTE FOR SYSTEMS BIOLOGY | 401 TERRY AVE N | SEATTLE | WA | 98109-5263 | KING | USA | F32CA247445 | A systems approach to understanding overall drug response in a heterogeneous tumor-cell population | 000 | 3 | NIH | 12/28/2023 | $0 |
| | 2024 | 2021 | INSTITUTE FOR SYSTEMS BIOLOGY | 401 TERRY AVE N | SEATTLE | WA | 98109-5263 | KING | USA | R01AI128215 | A systems analysis of drug tolerance in Mycobacterium tuberculosis | 000 | 5 | NIH | 2/7/2024 | -$505,858 |
| | 2024 | 2021 | INSTITUTE FOR SYSTEMS BIOLOGY | 401 TERRY AVE N | SEATTLE | WA | 98109-5263 | KING | USA | R01GM087221 | Shortening the development cycle time of Trans Proteomic Pipeline tools with high performance computing | 001 | 11 | NIH | 2/13/2024 | -$120 |
| | 2024 | 2021 | INSTITUTE FOR SYSTEMS BIOLOGY | 401 TERRY AVE N | SEATTLE | WA | 98109-5263 | KING | USA | R01GM087221 | Shortening the development cycle time of Trans Proteomic Pipeline tools with high performance computing | 000 | 11 | NIH | 2/13/2024 | -$629 |
| | 2024 | 2021 | INSTITUTE FOR SYSTEMS BIOLOGY | 401 TERRY AVE N | SEATTLE | WA | 98109-5263 | KING | USA | U01CA217655 | Steady states and cellular transitions associated with carcinogenesis and tumorprogression | 000 | 6 | NIH | 3/4/2024 | -$77,682 |
| | 2024 | 2020 | INSTITUTE FOR SYSTEMS BIOLOGY | 401 TERRY AVE N | SEATTLE | WA | 98109-5263 | KING | USA | OT2TR003450 | EVIDARA: Automated Evidential Support from Raw Data for relay agents in Biomedical KG Queries | 000 | 1 | NIH | 11/30/2023 | $0 |
| | 2024 | 2020 | INSTITUTE FOR SYSTEMS BIOLOGY | 401 TERRY AVE N | SEATTLE | WA | 98109-5263 | KING | USA | OT2TR003443 | DOCKET: accelerating knowledge extraction from biomedical data sets | 000 | 1 | NIH | 11/30/2023 | $0 |
|
| Issue Date FY: 2023 ( Subtotal = $14,715,656 ) (Continued on the next page) |
| | 2023 | 2023 | INSTITUTE FOR SYSTEMS BIOLOGY | 401 TERRY AVE N | SEATTLE | WA | 98109-5263 | KING | USA | R01AI141953 | A systems approach to manipulate microbial adaptation to structured environments | 000 | 5 | NIH | 5/26/2023 | $871,106 |
| | 2023 | 2023 | INSTITUTE FOR SYSTEMS BIOLOGY | 401 TERRY AVE N | SEATTLE | WA | 98109-5263 | KING | USA | R01AI155685 | Host innate immune mechanisms control temporal expression of flagellin by pathogenic Salmonella | 000 | 3 | NIH | 5/24/2023 | $564,485 |
| | 2023 | 2023 | INSTITUTE FOR SYSTEMS BIOLOGY | 401 TERRY AVE N | SEATTLE | WA | 98109-5263 | KING | USA | R35GM150994 | Single-cell transcriptomics of complex bacterial communities | 000 | 1 | NIH | 7/8/2023 | $470,000 |
| | 2023 | 2023 | INSTITUTE FOR SYSTEMS BIOLOGY | 401 TERRY AVE N | SEATTLE | WA | 98109-5263 | KING | USA | R00AG070102 | Development of a Predictive Frailty Clock & Longitudinal Investigation of its Epigenetic Determinants | 000 | 3 | NIH | 5/8/2023 | $249,000 |
| | 2023 | 2023 | INSTITUTE FOR SYSTEMS BIOLOGY | 401 TERRY AVE N | SEATTLE | WA | 98109-5263 | KING | USA | K99HD112600 | Enhancing personalized insights into common obstetric disorders using longitudinal deep-phenotyping data | 000 | 1 | NIH | 8/9/2023 | $142,830 |
| | 2023 | 2023 | INSTITUTE FOR SYSTEMS BIOLOGY | 401 TERRY AVE N | SEATTLE | WA | 98109-5263 | KING | USA | R01CA259469 | Systems biology of intratumoral heterogeneity in glioblastoma | 000 | 2 | NIH | 12/20/2022 | $671,460 |
| | 2023 | 2023 | INSTITUTE FOR SYSTEMS BIOLOGY | 401 TERRY AVE N | SEATTLE | WA | 98109-5263 | KING | USA | R01CA259469 | Systems biology of intratumoral heterogeneity in glioblastoma | 001 | 2 | NIH | 5/5/2023 | $76,187 |
| | 2023 | 2023 | INSTITUTE FOR SYSTEMS BIOLOGY | 401 TERRY AVE N | SEATTLE | WA | 98109-5263 | KING | USA | R01CA270210 | Prototype System for AML Digital Twins | 000 | 1 | NIH | 12/22/2022 | $733,906 |
| | 2023 | 2023 | INSTITUTE FOR SYSTEMS BIOLOGY | 401 TERRY AVE N | SEATTLE | WA | 98109-5263 | KING | USA | R01CA270210 | Prototype System for AML Digital Twins | 001 | 1 | NIH | 1/23/2023 | $0 |
| | 2023 | 2023 | INSTITUTE FOR SYSTEMS BIOLOGY | 401 TERRY AVE N | SEATTLE | WA | 98109-5263 | KING | USA | R01AI128215 | A systems analysis of drug tolerance in Mycobacterium tuberculosis | 000 | 7 | NIH | 6/30/2023 | $886,311 |
| | 2023 | 2023 | INSTITUTE FOR SYSTEMS BIOLOGY | 401 TERRY AVE N | SEATTLE | WA | 98109-5263 | KING | USA | R01AI163131 | NLRP3 inflammasome activation and its crosstalk with RLR signaling at the mitochondria | 000 | 3 | NIH | 5/2/2023 | $457,500 |
| | 2023 | 2023 | INSTITUTE FOR SYSTEMS BIOLOGY | 401 TERRY AVE N | SEATTLE | WA | 98109-5263 | KING | USA | R01AI163131 | NLRP3 inflammasome activation and its crosstalk with RLR signaling at the mitochondria | 001 | 3 | NIH | 5/16/2023 | $0 |
| | 2023 | 2023 | INSTITUTE FOR SYSTEMS BIOLOGY | 401 TERRY AVE N | SEATTLE | WA | 98109-5263 | KING | USA | R01HG002939 | Development and Maintenance of RepeatMasker and RepeatModeler | 000 | 17 | NIH | 3/1/2023 | $588,173 |
| | 2023 | 2023 | INSTITUTE FOR SYSTEMS BIOLOGY | 401 TERRY AVE N | SEATTLE | WA | 98109-5263 | KING | USA | U54CA274509 | Data-driven Patient-Specific Agent Based Models of Metastatic Melanoma for Immunotherapy Response Prediction | 002 | 2 | NIH | 8/31/2023 | $147,236 |
| | 2023 | 2023 | INSTITUTE FOR SYSTEMS BIOLOGY | 401 TERRY AVE N | SEATTLE | WA | 98109-5263 | KING | USA | U54CA274509 | Data-driven Patient-Specific Agent Based Models of Metastatic Melanoma for Immunotherapy Response Prediction | 001 | 2 | NIH | 8/30/2023 | $2,548,990 |
| | 2023 | 2023 | INSTITUTE FOR SYSTEMS BIOLOGY | 401 TERRY AVE N | SEATTLE | WA | 98109-5263 | KING | USA | R01DK133468 | CyberGut: towards personalized human-microbiome metabolic modeling for precision health and nutrition | 000 | 2 | NIH | 4/4/2023 | $758,781 |
| | 2023 | 2023 | INSTITUTE FOR SYSTEMS BIOLOGY | 401 TERRY AVE N | SEATTLE | WA | 98109-5263 | KING | USA | R01DK133468 | CyberGut: towards personalized human-microbiome metabolic modeling for precision health and nutrition | 001 | 2 | NIH | 9/6/2023 | $281,306 |
| | 2023 | 2023 | INSTITUTE FOR SYSTEMS BIOLOGY | 401 TERRY AVE N | SEATTLE | WA | 98109-5263 | KING | USA | R01CA264090 | Nano and biomolecular engineered technologies for neoantigen-specific T cell capture and characterization | 000 | 3 | NIH | 8/8/2023 | $528,041 |
| | 2023 | 2023 | INSTITUTE FOR SYSTEMS BIOLOGY | 401 TERRY AVE N | SEATTLE | WA | 98109-5263 | KING | USA | R33CA256112 | Liquid biopsy-based toolkits for neoantigen and cognate TCR discovery for cancer immunotherapy | 001 | 3 | NIH | 8/29/2023 | $442,712 |
| | 2023 | 2023 | INSTITUTE FOR SYSTEMS BIOLOGY | 401 TERRY AVE N | SEATTLE | WA | 98109-5263 | KING | USA | R01CA255536 | Instability of Cancer Cell States in Tumor progression (ICCS) | 000 | 3 | NIH | 8/28/2023 | $486,752 |
| | 2023 | 2023 | INSTITUTE FOR SYSTEMS BIOLOGY | 401 TERRY AVE N | SEATTLE | WA | 98109-5263 | KING | USA | R01DK098449 | Transcriptional Control During Erythropoiesis | 002 | 9 | NIH | 8/31/2023 | $151,000 |
| | 2023 | 2023 | INSTITUTE FOR SYSTEMS BIOLOGY | 401 TERRY AVE N | SEATTLE | WA | 98109-5263 | KING | USA | R01DK098449 | Transcriptional Control During Erythropoiesis | 001 | 9 | NIH | 4/27/2023 | $616,474 |
| | 2023 | 2023 | INSTITUTE FOR SYSTEMS BIOLOGY | 401 TERRY AVE N | SEATTLE | WA | 98109-5263 | KING | USA | OT2TR003450 | EVIDARA: Automated Evidential Support from Raw Data for relay agents in Biomedical KG Queries | 001 | 1 | NIH | 12/13/2022 | $532,891 |
| | 2023 | 2023 | INSTITUTE FOR SYSTEMS BIOLOGY | 401 TERRY AVE N | SEATTLE | WA | 98109-5263 | KING | USA | OT2TR003443 | DOCKET: accelerating knowledge extraction from biomedical data sets | 001 | 1 | NIH | 12/10/2022 | $609,144 |
| | 2023 | 2023 | INSTITUTE FOR SYSTEMS BIOLOGY | 401 TERRY AVE N | SEATTLE | WA | 98109-5263 | KING | USA | R01AI148489 | Elucidating the role of TSR glycosylation in Plasmodium parasites | 000 | 4 | NIH | 6/30/2023 | $833,059 |
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