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Understanding alpha-gal red meat allergy

Award Number: R01AI135049
ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/24/2018
PERIOD OF PERFORMANCE END DATE: 01/31/2029

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Understanding alpha-gal red meat allergy - PROJECT SUMMARY / ABSTRACT Anaphylaxis is a severe allergic reaction that can be rapidly progressing and fatal. In instances where the triggering allergen is not known, establishing the etiology of anaphylaxis is pivotal to long-term risk management. Our recent work has identified a novel IgE antibody response to a mammalian oligosaccharide epitope, galactose-alpha-1,3-galactose (alpha-gal), that has been associated with two distinct forms of anaphylaxis: i) immediate onset anaphylaxis during first exposure to intravenous cetuximab, and ii) delayed onset anaphylaxis 3-6 hours after ingestion of mammalian food products (e.g., beef and pork). The overarching goal for this renewal is to define whether the risk for development of an alpha-gal IgE response is intrinsic to the host (genetics) or external with a specific factor in ticks. These studies will provide insight into the factors that govern allergic responses and control IgE production more generally. The significance of investigating these reactions comes not only from the obvious importance of understanding a novel life-threatening form of food allergy, but also because of the possibility of defining a totally new mechanism for reactions related to an important food substance. Our plan of research focuses on using a cutting- edge, combined transcriptomic (single cell RNA sequencing) and surface marker expression approach to deeply immunophenotype the cells in humans with alpha-gal allergy. This approach will allow us to define the factors underpinning how tick bites transcriptionally initiate the IgE response. We believe that IgE to alpha-gal represents a novel cause of food allergy and overall, these studies are uniquely positioned to provide additional insight into a recently recognized allergic response that affects >40,000 patients in the U.S. alone and position the research to make important advances for prevention and treatment of alpha-gal syndrome (AGS).


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $770,209 )
2026	2026	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Allergy and Infectious Diseases Research	000	8	1/14/2026	NON-COMPETING CONTINUATION	$770,209
														Subtotal = $770,209

Issue Date FY: 2025 ( Subtotal = $770,209 )
2025	2025	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Allergy and Infectious Diseases Research	000	7	1/14/2025	NON-COMPETING CONTINUATION	$770,209
2025	2022	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Allergy and Infectious Diseases Research	001	5	2/14/2025	NON-COMPETING CONTINUATION	$0
														Subtotal = $770,209

Issue Date FY: 2024 ( Subtotal = $770,209 )
2024	2024	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Allergy and Infectious Diseases Research	002	6	4/4/2024	COMPETING CONTINUATION	$0
2024	2024	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Allergy and Infectious Diseases Research	003	6	5/28/2024	COMPETING CONTINUATION	$77,021
2024	2024	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Allergy and Infectious Diseases Research	001	6	3/25/2024	COMPETING CONTINUATION	$693,188
2024	2022	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Allergy and Infectious Diseases Research	000	5	3/15/2024	NON-COMPETING CONTINUATION	$0
														Subtotal = $770,209

Issue Date FY: 2022 ( Subtotal = $648,462 )
2022	2022	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Allergy and Infectious Diseases Research	001	5	8/29/2022	NON-COMPETING CONTINUATION	$221,471
2022	2022	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Allergy and Infectious Diseases Research	000	5	8/3/2022	NON-COMPETING CONTINUATION	$426,991
														Subtotal = $648,462

Issue Date FY: 2021 ( Subtotal = $426,621 )
2021	2021	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Allergy and Infectious Diseases Research	000	4	8/11/2021	NON-COMPETING CONTINUATION	$426,621
														Subtotal = $426,621

Issue Date FY: 2020 ( Subtotal = $459,827 )
2020	2020	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Allergy and Infectious Diseases Research	000	3	8/10/2020	NON-COMPETING CONTINUATION	$459,827
														Subtotal = $459,827

Issue Date FY: 2019 ( Subtotal = $462,261 )
2019	2019	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Allergy and Infectious Diseases Research	000	2	8/7/2019	NON-COMPETING CONTINUATION	$462,261
														Subtotal = $462,261

Issue Date FY: 2018 ( Subtotal = $477,297 )
2018	2018	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Allergy and Infectious Diseases Research	000	1	9/21/2018	NEW	$477,297
														Subtotal = $477,297

Grand Total All Awards = $4,785,095

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Understanding alpha-gal red meat allergy

Award Number: R01AI135049

ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/24/2018

PERIOD OF PERFORMANCE END DATE: 01/31/2029

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