Wednesday, July 2, 2025 7/2/2025

Characterization and disruption of bacterial microcompartment shells from human pathogens

Award Number: R01AI114975
ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 01/01/2015
PERIOD OF PERFORMANCE END DATE: 01/31/2025

Group Awards By:

View Award Description

Characterization and disruption of bacterial microcompartment shells from human pathogens - Project Summary/Abstract: Many pathogenic bacteria utilize protein-based nanoreactors called bacterial microcompartments to metabolize diverse nutritional sources. This helps pathogenic organisms thrive in human tissues. The bacterial microcompartment is a specialized organelle composed of enzymes surrounded by a protein shell. To function, compounds to be broken down within the bacterial microcompartment must cross the shell and, likewise, the breakdown products must egress the compartments. The goal of the proposed research is to study and disrupt the protein-protein interactions essential for shell integrity. In parallel, we will characterize the permeability properties of BMC shells, and screen for compounds that interfere with flux across the shells. Collectively these data will provide new knowledge about the structural basis of shell function and provide the foundation for producing therapeutics that disrupt shell assembly and permeability.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = -$243,940 )
2025	2022	THE REGENTS OF THE UNIVERSITY OF CALIFORNIA	1 CYCLOTRON RD	BERKELEY	CA	94720	ALAMEDA	USA	Allergy and Infectious Diseases Research	000	8	6/2/2025	NON-COMPETING CONTINUATION	-$243,940
														Subtotal = -$243,940

Issue Date FY: 2024 ( Subtotal = $0 )
2024	2022	THE REGENTS OF THE UNIVERSITY OF CALIFORNIA	1 CYCLOTRON RD	BERKELEY	CA	94720	ALAMEDA	USA	Allergy and Infectious Diseases Research	000	8	2/9/2024	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2022 ( Subtotal = $469,090 )
2022	2022	REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE	1 CYCLOTRON RD	BERKELEY	CA	94720	ALAMEDA	USA	Allergy and Infectious Diseases Research	000	8	1/21/2022	NON-COMPETING CONTINUATION	$469,090
														Subtotal = $469,090

Issue Date FY: 2021 ( Subtotal = $1 )
2021	2021	REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE	1 CYCLOTRON RD	BERKELEY	CA	94720	ALAMEDA	USA	Allergy and Infectious Diseases Research	000	7	4/9/2021	NON-COMPETING CONTINUATION	$1
														Subtotal = $1

Issue Date FY: 2020 ( Subtotal = $469,091 )
2020	2020	REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE	1 CYCLOTRON RD	BERKELEY	CA	94720	ALAMEDA	USA	Allergy and Infectious Diseases Research	000	6	2/5/2020	NON-COMPETING CONTINUATION	$469,091
														Subtotal = $469,091

Issue Date FY: 2019 ( Subtotal = $463,839 )
2019	2019	REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE	1 CYCLOTRON RD	BERKELEY	CA	94720	ALAMEDA	USA	Allergy and Infectious Diseases Research	000	5	1/11/2019	NON-COMPETING CONTINUATION	$463,839
														Subtotal = $463,839

Issue Date FY: 2018 ( Subtotal = $541,980 )
2018	2018	REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE	1 CYCLOTRON RD	BERKELEY	CA	94720	ALAMEDA	USA	Allergy and Infectious Diseases Research	001	4	1/31/2018	COMPETING CONTINUATION	$541,980
2018	2018	REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE	1 CYCLOTRON RD	BERKELEY	CA	94720	ALAMEDA	USA	Allergy and Infectious Diseases Research	004	4	5/3/2018	COMPETING CONTINUATION	$367,853
2018	2017	REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE	1 CYCLOTRON RD	BERKELEY	CA	94720	ALAMEDA	USA	Allergy and Infectious Diseases Research	003	3	5/3/2018	NON-COMPETING CONTINUATION	-$363,600
2018	2017	REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE	1 CYCLOTRON RD	BERKELEY	CA	94720	ALAMEDA	USA	Allergy and Infectious Diseases Research	000	3	1/29/2018	NON-COMPETING CONTINUATION	$0
2018	2016	REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE	1 CYCLOTRON RD	BERKELEY	CA	94720	ALAMEDA	USA	Allergy and Infectious Diseases Research	002	2	5/3/2018	NON-COMPETING CONTINUATION	-$4,253
														Subtotal = $541,980

Issue Date FY: 2017 ( Subtotal = $363,600 )
2017	2017	REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE	1 CYCLOTRON RD	BERKELEY	CA	94720	ALAMEDA	USA	Allergy and Infectious Diseases Research	000	3	12/9/2016	NON-COMPETING CONTINUATION	$363,600
														Subtotal = $363,600

Issue Date FY: 2016 ( Subtotal = $363,600 )
2016	2016	LAWRENCE BERKELEY LABORATORY	POST OFFICE BOX 528	BERKELEY	CA	94701	ALAMEDA	USA	Allergy and Infectious Diseases Research	000	2	12/15/2015	NON-COMPETING CONTINUATION	$363,600
														Subtotal = $363,600

Issue Date FY: 2015 ( Subtotal = $363,600 )
2015	2015	LAWRENCE BERKELEY LABORATORY	POST OFFICE BOX 528	BERKELEY	CA	94701	ALAMEDA	USA	Allergy and Infectious Diseases Research	001	1	3/27/2015	NEW	$152,507
2015	2015	LAWRENCE BERKELEY LABORATORY	POST OFFICE BOX 528	BERKELEY	CA	94701	ALAMEDA	USA	Allergy and Infectious Diseases Research	000	1	12/17/2014	NEW	$211,093
														Subtotal = $363,600

Grand Total All Awards = $2,790,861

Top

All Categories

About

Search

Reports

Data Submission

Award Information

Characterization and disruption of bacterial microcompartment shells from human pathogens

Award Number: R01AI114975

ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 01/01/2015

PERIOD OF PERFORMANCE END DATE: 01/31/2025

Federal Websites

Department of Health & Human Services

HHS Operating Divisions

HHS Staff Divisions

Download A Document Viewer