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Genetic Analysis of Cryptosporidium

Award Number: R01AI112427
ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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Genetic Analysis of Cryptosporidium - Cryptosporidium is an apicomplexan parasite and one of the most important causes of severe diarrheal disease. More than 50% of U.S. outbreaks linked to water use are caused by Cryptosporidium and the parasite is thus considered a category B potential bioterrorism agent. Immunosuppressed patients are extremely susceptible and suffer life-threatening chronic disease, cryptosporidiosis is an original AIDS defining opportunistic infections. Globally, children under the age of two bear the main disease burden and Cryptosporidium is the second most important diarrheal pathogen in this group. Over the initial period of support we developed stable transformation, a series of reporter genes and CRISPR-Cas9 mediated gene knock out. We apply and further hone these new tools to investigate how this intracellular parasite manipulates its host cell. Cryptosporidium thrives in a uniquely remodeled cellular niche cells that is critical to pathogenesis, drug susceptibility and immune interaction. Our central hypothesis is that the parasite injects proteins directly into host enterocytes and that those proteins are the mechanistic effectors of invasion, remodeling and immune evasion. We have discovered the first set of such factors in C. parvum. This application will use an array of modern approaches to define the parasite's exported proteome and to understand the function of effector proteins to first establish and then maintain parasite infection.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = -$70 )
2025	2023	TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA, THE	3451 WALNUT ST STE 440A	PHILADELPHIA	PA	19104	PHILADELPHIA	USA	Allergy and Infectious Diseases Research	000	11	2/24/2025	NON-COMPETING CONTINUATION	-$70
														Subtotal = -$70

Issue Date FY: 2024 ( Subtotal = $0 )
2024	2023	TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA, THE	3451 WALNUT ST STE 440A	PHILADELPHIA	PA	19104	PHILADELPHIA	USA	Allergy and Infectious Diseases Research	000	11	6/13/2024	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2023 ( Subtotal = $393,350 )
2023	2023	TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA, THE	3451 WALNUT ST STE 440A	PHILADELPHIA	PA	19104	PHILADELPHIA	USA	Allergy and Infectious Diseases Research	000	11	3/30/2023	NON-COMPETING CONTINUATION	$393,350
														Subtotal = $393,350

Issue Date FY: 2022 ( Subtotal = $393,350 )
2022	2022	TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA, THE	3451 WALNUT ST STE 440A	PHILADELPHIA	PA	19104	PHILADELPHIA	USA	Allergy and Infectious Diseases Research	000	10	4/18/2022	NON-COMPETING CONTINUATION	$393,350
														Subtotal = $393,350

Issue Date FY: 2021 ( Subtotal = $393,350 )
2021	2021	TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA, THE	3451 WALNUT ST STE 440A	PHILADELPHIA	PA	19104	PHILADELPHIA	USA	Allergy and Infectious Diseases Research	000	9	4/2/2021	NON-COMPETING CONTINUATION	$393,350
														Subtotal = $393,350

Issue Date FY: 2020 ( Subtotal = $393,350 )
2020	2020	TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA, THE	3451 WALNUT ST STE 440A	PHILADELPHIA	PA	19104	PHILADELPHIA	USA	Allergy and Infectious Diseases Research	000	8	4/24/2020	NON-COMPETING CONTINUATION	$393,350
														Subtotal = $393,350

Issue Date FY: 2019 ( Subtotal = $393,350 )
2019	2019	TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA, THE	3451 WALNUT ST STE 440A	PHILADELPHIA	PA	19104	PHILADELPHIA	USA	Allergy and Infectious Diseases Research	000	7	3/20/2019	COMPETING CONTINUATION	$393,350
2019	2019	TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA, THE	3451 WALNUT ST STE 440A	PHILADELPHIA	PA	19104	PHILADELPHIA	USA	Allergy and Infectious Diseases Research	003	7	9/24/2019	COMPETING CONTINUATION	$453,220
2019	2018	TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA, THE	3451 WALNUT ST STE 440A	PHILADELPHIA	PA	19104	PHILADELPHIA	USA	Allergy and Infectious Diseases Research	001	6	9/24/2019	NON-COMPETING CONTINUATION	-$372,500
2019	2017	TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA, THE	3451 WALNUT ST STE 440A	PHILADELPHIA	PA	19104	PHILADELPHIA	USA	Allergy and Infectious Diseases Research	002	5	9/24/2019	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	-$80,720
														Subtotal = $393,350

Issue Date FY: 2018 ( Subtotal = $372,500 )
2018	2018	TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA, THE	3451 WALNUT ST	PHILADELPHIA	PA	19104	PHILADELPHIA	USA	Allergy and Infectious Diseases Research	002	6	3/30/2018	NON-COMPETING CONTINUATION	$372,500
2018	2017	UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC.	310 EAST CAMPUS RD TUCKER HALL ROOM 409	ATHENS	GA	30602	CLARKE	USA	Allergy and Infectious Diseases Research	000	4	1/10/2018	NON-COMPETING CONTINUATION	-$211,424
2018	2017	TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA, THE	3451 WALNUT ST	PHILADELPHIA	PA	19104	PHILADELPHIA	USA	Allergy and Infectious Diseases Research	001	5	1/10/2018	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$211,424
														Subtotal = $372,500

Issue Date FY: 2017 ( Subtotal = $717,500 )
2017	2017	UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC.	310 EAST CAMPUS RD TUCKER HALL ROOM 409	ATHENS	GA	30602	CLARKE	USA	Allergy and Infectious Diseases Research	001	4	8/30/2017	NON-COMPETING CONTINUATION	$0
2017	2017	TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA, THE	3451 WALNUT ST	PHILADELPHIA	PA	19104	PHILADELPHIA	USA	Allergy and Infectious Diseases Research	002	5	9/1/2017	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$345,000
2017	2017	UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC.	310 EAST CAMPUS RD TUCKER HALL ROOM 409	ATHENS	GA	30602	CLARKE	USA	Allergy and Infectious Diseases Research	000	4	4/12/2017	NON-COMPETING CONTINUATION	$372,500
														Subtotal = $717,500

Issue Date FY: 2016 ( Subtotal = $372,500 )
2016	2016	UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC	BUSINESS SERVICES BUILDING	ATHENS	GA	30602	CLARKE	USA	Allergy and Infectious Diseases Research	000	3	4/19/2016	NON-COMPETING CONTINUATION	$372,500
														Subtotal = $372,500

Issue Date FY: 2015 ( Subtotal = $372,500 )
2015	2015	UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC	BUSINESS SERVICES BUILDING	ATHENS	GA	30602	CLARKE	USA	Allergy and Infectious Diseases Research	001	2	8/14/2015	NON-COMPETING CONTINUATION	$0
2015	2015	UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC	BUSINESS SERVICES BUILDING	ATHENS	GA	30602	CLARKE	USA	Allergy and Infectious Diseases Research	000	2	4/24/2015	NON-COMPETING CONTINUATION	$372,500
														Subtotal = $372,500

Issue Date FY: 2014 ( Subtotal = $372,500 )
2014	2014	UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC	BUSINESS SERVICES BUILDING	ATHENS	GA	30602	CLARKE	USA	Allergy and Infectious Diseases Research	000	1	5/9/2014	NEW	$260,750
2014	2014	UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC	BUSINESS SERVICES BUILDING	ATHENS	GA	30602	CLARKE	USA	Allergy and Infectious Diseases Research	001	1	5/30/2014	NEW	$111,750
														Subtotal = $372,500

Grand Total All Awards = $4,174,180

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Genetic Analysis of Cryptosporidium

Award Number: R01AI112427

ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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