Sunday, May 11, 2025 5/11/2025

Transcriptional Regulation of Antibody Responses and Immunity

Award Number: R01AI099108
ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

Group Awards By:

View Award Description

Transcriptional Regulation of Antibody Responses and Immunity - ABSTRACT The duration of antibody-mediated immunity varies widely with the specific immunization or infection for reasons that remain difficult to understand or predict. The specific features of molecular circuitry in B cells and plasma cells that are responsible for these differences have still not been defined. In this application, which requests a second renewal of our R01 award, we seek to objectively define 1) molecular programs and cellular trajectories that lead to long-lived plasma cells in primary responses; 2) transcriptional and epigenetic features of memory B cells that precede durable recall responses. We will employ two BTB-POZ transcription factors that functionally oppose each other to gain molecular footholds on programs that control plasma cell lifespan. Modern single cell transcriptional and epigenetic programs will be employed alongside classic model antigens and adjuvants and new genetic tools to manipulate genes in vivo. Though the experimental plan is fundamental and basic in nature, the hope is that this work will lead to a set of rules that help predict and optimize the duration of humoral immunity.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = $528,044 )
2024	2024	UNIVERSITY OF ARIZONA	845 N PARK AVE RM 538	TUCSON	AZ	85721	PIMA	USA	Allergy and Infectious Diseases Research	000	12	4/9/2024	NON-COMPETING CONTINUATION	$528,044
2024	2023	UNIVERSITY OF ARIZONA	845 N PARK AVE RM 538	TUCSON	AZ	85721	PIMA	USA	Allergy and Infectious Diseases Research	002	11	9/27/2024	COMPETING CONTINUATION	$458
2024	2022	UNIVERSITY OF ARIZONA	845 N PARK AVE RM 538	TUCSON	AZ	85721	PIMA	USA	Allergy and Infectious Diseases Research	001	10	9/27/2024	NON-COMPETING CONTINUATION	-$458
														Subtotal = $528,044

Issue Date FY: 2023 ( Subtotal = $531,017 )
2023	2023	UNIVERSITY OF ARIZONA	845 N PARK AVE RM 538	TUCSON	AZ	85721	PIMA	USA	Allergy and Infectious Diseases Research	001	11	5/8/2023	COMPETING CONTINUATION	$531,017
2023	2023	UNIVERSITY OF ARIZONA	845 N PARK AVE RM 538	TUCSON	AZ	85721	PIMA	USA	Allergy and Infectious Diseases Research	002	11	6/2/2023	COMPETING CONTINUATION	$0
2023	2022	UNIVERSITY OF ARIZONA	845 N PARK AVE RM 538	TUCSON	AZ	85721	PIMA	USA	Allergy and Infectious Diseases Research	000	10	5/8/2023	NON-COMPETING CONTINUATION	$0
														Subtotal = $531,017

Issue Date FY: 2022 ( Subtotal = $460,500 )
2022	2022	UNIVERSITY OF ARIZONA	888 N EUCLID AVE RM 510	TUCSON	AZ	85719	PIMA	USA	Allergy and Infectious Diseases Research	000	10	11/23/2021	NON-COMPETING CONTINUATION	$460,500
														Subtotal = $460,500

Issue Date FY: 2021 ( Subtotal = $460,500 )
2021	2021	UNIVERSITY OF ARIZONA	888 N EUCLID AVE RM 510	TUCSON	AZ	85719	PIMA	USA	Allergy and Infectious Diseases Research	000	9	11/17/2020	NON-COMPETING CONTINUATION	$460,500
														Subtotal = $460,500

Issue Date FY: 2020 ( Subtotal = $460,500 )
2020	2020	UNIVERSITY OF ARIZONA	888 N EUCLID AVE RM 510	TUCSON	AZ	85719	PIMA	USA	Allergy and Infectious Diseases Research	000	8	11/25/2019	NON-COMPETING CONTINUATION	$460,500
														Subtotal = $460,500

Issue Date FY: 2019 ( Subtotal = $460,500 )
2019	2019	UNIVERSITY OF ARIZONA	888 N EUCLID AVE RM 510	TUCSON	AZ	85719	PIMA	USA	Allergy and Infectious Diseases Research	000	7	11/20/2018	NON-COMPETING CONTINUATION	$460,500
														Subtotal = $460,500

Issue Date FY: 2018 ( Subtotal = $451,517 )
2018	2018	UNIVERSITY OF ARIZONA	888 N EUCLID AVE RM 510	TUCSON	AZ	85719	PIMA	USA	Allergy and Infectious Diseases Research	002	6	7/18/2018	COMPETING CONTINUATION	$0
2018	2018	UNIVERSITY OF ARIZONA	888 N EUCLID AVE RM 510	TUCSON	AZ	85719	PIMA	USA	Allergy and Infectious Diseases Research	001	6	12/19/2017	COMPETING CONTINUATION	$460,500
2018	2016	WASHINGTON UNIVERSITY, THE	ONE BROOKINGS DR	SAINT LOUIS	MO	63130	SAINT LOUIS	USA	Allergy and Infectious Diseases Research	000	5	12/6/2017	EXTENSION WITH OR WITHOUT FUNDS	-$8,983
														Subtotal = $451,517

Issue Date FY: 2017 ( Subtotal = $0 )
2017	2016	WASHINGTON UNIVERSITY, THE	ONE BROOKINGS DR	SAINT LOUIS	MO	63130	SAINT LOUIS	USA	Allergy and Infectious Diseases Research	001	5	12/1/2016	EXTENSION WITH OR WITHOUT FUNDS	$12,322
2017	2015	WASHINGTON UNIVERSITY, THE	ONE BROOKINGS DR	SAINT LOUIS	MO	63130	SAINT LOUIS	USA	Allergy and Infectious Diseases Research	000	4	12/1/2016	NON-COMPETING CONTINUATION	-$12,322
														Subtotal = $0

Issue Date FY: 2016 ( Subtotal = $530,000 )
2016	2016	WASHINGTON UNIVERSITY	CAMPUS BOX 1034	SAINT LOUIS	MO	63112	SAINT LOUIS CITY	USA	Allergy and Infectious Diseases Research	001	5	8/19/2016	EXTENSION WITH OR WITHOUT FUNDS	$150,000
2016	2016	WASHINGTON UNIVERSITY	CAMPUS BOX 1034	SAINT LOUIS	MO	63112	SAINT LOUIS CITY	USA	Allergy and Infectious Diseases Research	000	5	8/4/2016	EXTENSION WITH OR WITHOUT FUNDS	$380,000
														Subtotal = $530,000

Issue Date FY: 2015 ( Subtotal = $380,000 )
2015	2015	WASHINGTON UNIVERSITY	CAMPUS BOX 1034	SAINT LOUIS	MO	63112	SAINT LOUIS CITY	USA	Allergy and Infectious Diseases Research	000	4	8/5/2015	NON-COMPETING CONTINUATION	$380,000
														Subtotal = $380,000

Issue Date FY: 2014 ( Subtotal = $380,000 )
2014	2014	WASHINGTON UNIVERSITY	CAMPUS BOX 1034	SAINT LOUIS	MO	63112	SAINT LOUIS CITY	USA	Allergy and Infectious Diseases Research	000	3	8/1/2014	NON-COMPETING CONTINUATION	$380,000
														Subtotal = $380,000

Issue Date FY: 2013 ( Subtotal = $357,200 )
2013	2013	WASHINGTON UNIVERSITY	CAMPUS BOX 1034	SAINT LOUIS	MO	63112	SAINT LOUIS CITY	USA	Allergy and Infectious Diseases Research	000	2	7/29/2013	NON-COMPETING CONTINUATION	$357,200
														Subtotal = $357,200

Issue Date FY: 2012 ( Subtotal = $380,000 )
2012	2012	WASHINGTON UNIVERSITY	CAMPUS BOX 1034	SAINT LOUIS	MO	63112	SAINT LOUIS CITY	USA	Allergy and Infectious Diseases Research	000	1	9/24/2012	NEW	$380,000
														Subtotal = $380,000

Grand Total All Awards = $5,379,778

Top

All Categories

About

Search

Reports

Data Submission

Award Information

Transcriptional Regulation of Antibody Responses and Immunity

Award Number: R01AI099108

ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

Federal Websites

Department of Health & Human Services

HHS Operating Divisions

HHS Staff Divisions

Download A Document Viewer