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Novel Antigen Identification for an enterotoxigenic E coli vaccine

Award Number: R01AI089894
ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 07/01/2010
PERIOD OF PERFORMANCE END DATE: 02/28/2026

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Novel Antigen Identification for an enterotoxigenic E coli vaccine - Project Summary/Abstract The long-term objective of this project is to develop a safe and broadly protective vaccine for enterotoxigenic E. coli (ETEC), a common cause of diarrhea worldwide. This highly collaborative project will rely on the combined resources, and innovation of investigators with complementary expertise in molecular microbiology and microbial pathogenesis, vaccinology, immunology, and advanced state-of-the-art structural biology to investigate novel targets for ETEC vaccine development. Specifically, the project will: (1) examine whether two key surface proteins of ETEC can provoke immune recall (memory) responses that are thought to be involved in sustained protection against infection (2) develop monoclonal antibodies from circulating immune cells obtained from blood samples following natural infections (3) map where these antibodies bind on the two surface proteins that we plan to use in vaccines (4) determine the overall structure of the proteins that we plan to use in vaccines (5) test the ability of these monoclonal antibodies to neutralize protein function and the ability of the bacteria to deliver toxins (6) vaccinate mice with these proteins to test protection against infection (7) test the activity of antibodies from mice and map where antibodies from mice bind the vaccine proteins relative to the human antibodies. The project will answer fundamental questions about the nature of the two proteins that are relevant not only to ETEC but to other important pathogens that secrete similar proteins. Most importantly the project is expected to provide critical information that can be translated into efficient design of a multi-featured vaccine for ETEC that provides broad-based long-term protection.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $154,851 )
2025	2025	WASHINGTON UNIVERSITY, THE	1 BROOKINGS DR	SAINT LOUIS	MO	63130	SAINT LOUIS	USA	Allergy and Infectious Diseases Research	000	17	8/1/2025	NON-COMPETING CONTINUATION	$154,851
														Subtotal = $154,851

Issue Date FY: 2024 ( Subtotal = $453,078 )
2024	2024	WASHINGTON UNIVERSITY, THE	ONE BROOKINGS DR	SAINT LOUIS	MO	63110	SAINT LOUIS CITY	USA	Allergy and Infectious Diseases Research	000	16	3/26/2024	NON-COMPETING CONTINUATION	$392,285
2024	2024	WASHINGTON UNIVERSITY, THE	ONE BROOKINGS DR	SAINT LOUIS	MO	63110	SAINT LOUIS CITY	USA	Allergy and Infectious Diseases Research	001	16	6/14/2024	NON-COMPETING CONTINUATION	$60,793
														Subtotal = $453,078

Issue Date FY: 2023 ( Subtotal = $607,929 )
2023	2023	WASHINGTON UNIVERSITY, THE	ONE BROOKINGS DR	SAINT LOUIS	MO	63130	SAINT LOUIS	USA	Allergy and Infectious Diseases Research	000	15	2/8/2023	NON-COMPETING CONTINUATION	$607,929
														Subtotal = $607,929

Issue Date FY: 2022 ( Subtotal = $629,668 )
2022	2022	WASHINGTON UNIVERSITY, THE	ONE BROOKINGS DR	SAINT LOUIS	MO	63130	SAINT LOUIS	USA	Allergy and Infectious Diseases Research	000	14	2/18/2022	NON-COMPETING CONTINUATION	$629,668
														Subtotal = $629,668

Issue Date FY: 2021 ( Subtotal = $629,668 )
2021	2021	WASHINGTON UNIVERSITY, THE	ONE BROOKINGS DR	SAINT LOUIS	MO	63130	SAINT LOUIS	USA	Allergy and Infectious Diseases Research	002	13	3/9/2021	NON-COMPETING CONTINUATION	$629,668
2021	2020	WASHINGTON UNIVERSITY, THE	ONE BROOKINGS DR	SAINT LOUIS	MO	63130	SAINT LOUIS	USA	Allergy and Infectious Diseases Research	001	12	2/23/2021	COMPETING CONTINUATION	$146,295
2021	2019	WASHINGTON UNIVERSITY, THE	ONE BROOKINGS DR	SAINT LOUIS	MO	63130	SAINT LOUIS	USA	Allergy and Infectious Diseases Research	000	11	2/23/2021	NON-COMPETING CONTINUATION	-$146,295
														Subtotal = $629,668

Issue Date FY: 2020 ( Subtotal = $570,104 )
2020	2020	WASHINGTON UNIVERSITY, THE	ONE BROOKINGS DR	SAINT LOUIS	MO	63130	SAINT LOUIS	USA	Allergy and Infectious Diseases Research	000	12	3/3/2020	COMPETING CONTINUATION	$570,104
														Subtotal = $570,104

Issue Date FY: 2019 ( Subtotal = $392,654 )
2019	2019	WASHINGTON UNIVERSITY, THE	ONE BROOKINGS DR	SAINT LOUIS	MO	63130	SAINT LOUIS	USA	Allergy and Infectious Diseases Research	000	11	1/2/2019	NON-COMPETING CONTINUATION	$392,654
														Subtotal = $392,654

Issue Date FY: 2018 ( Subtotal = $445,698 )
2018	2018	WASHINGTON UNIVERSITY, THE	ONE BROOKINGS DR	SAINT LOUIS	MO	63130	SAINT LOUIS	USA	Allergy and Infectious Diseases Research	000	10	1/22/2018	NON-COMPETING CONTINUATION	$445,698
														Subtotal = $445,698

Issue Date FY: 2017 ( Subtotal = $550,403 )
2017	2017	WASHINGTON UNIVERSITY, THE	ONE BROOKINGS DR	SAINT LOUIS	MO	63130	SAINT LOUIS	USA	Allergy and Infectious Diseases Research	001	9	1/9/2017	NON-COMPETING CONTINUATION	$494,875
2017	2016	WASHINGTON UNIVERSITY, THE	ONE BROOKINGS DR	SAINT LOUIS	MO	63130	SAINT LOUIS	USA	Allergy and Infectious Diseases Research	000	8	11/18/2016	NON-COMPETING CONTINUATION	$55,528
														Subtotal = $550,403

Issue Date FY: 2016 ( Subtotal = $387,407 )
2016	2016	WASHINGTON UNIVERSITY	CAMPUS BOX 1034	SAINT LOUIS	MO	63112	SAINT LOUIS CITY	USA	Allergy and Infectious Diseases Research	000	8	1/11/2016	NON-COMPETING CONTINUATION	$387,407
														Subtotal = $387,407

Issue Date FY: 2015 ( Subtotal = $227,200 )
2015	2015	WASHINGTON UNIVERSITY	CAMPUS BOX 1034	SAINT LOUIS	MO	63112	SAINT LOUIS CITY	USA	Allergy and Infectious Diseases Research	001	7	7/28/2015	COMPETING CONTINUATION	$227,200
2015	2014	WASHINGTON UNIVERSITY	CAMPUS BOX 1034	SAINT LOUIS	MO	63112	SAINT LOUIS CITY	USA	Allergy and Infectious Diseases Research	000	6	7/24/2015	NON-COMPETING CONTINUATION	$0
														Subtotal = $227,200

Issue Date FY: 2014 ( Subtotal = $289,221 )
2014	2014	WASHINGTON UNIVERSITY	CAMPUS BOX 1034	SAINT LOUIS	MO	63112	SAINT LOUIS CITY	USA	Allergy and Infectious Diseases Research	000	6	6/12/2014	NON-COMPETING CONTINUATION	$289,221
														Subtotal = $289,221

Issue Date FY: 2013 ( Subtotal = $257,536 )
2013	2013	WASHINGTON UNIVERSITY	CAMPUS BOX 1034	SAINT LOUIS	MO	63112	SAINT LOUIS CITY	USA	Allergy and Infectious Diseases Research	000	5	6/13/2013	NON-COMPETING CONTINUATION	$257,536
														Subtotal = $257,536

Issue Date FY: 2012 ( Subtotal = $378,118 )
2012	2012	WASHINGTON UNIVERSITY	CAMPUS BOX 1034	SAINT LOUIS	MO	63112	SAINT LOUIS CITY	USA	Allergy and Infectious Diseases Research	002	4	6/12/2012	NON-COMPETING CONTINUATION	$312,396
2012	2011	WASHINGTON UNIVERSITY	CAMPUS BOX 1034	SAINT LOUIS	MO	63112	SAINT LOUIS CITY	USA	Allergy and Infectious Diseases Research	001	3	3/30/2012	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$259,647
2012	2011	UNIVERSITY OF TENNESSEE CENTER FOR THE HEALTH SCIENCES	62 SOUTH DUNLAP STREET	MEMPHIS	TN	38103	SHELBY	USA	Allergy and Infectious Diseases Research	000	2	3/30/2012	NON-COMPETING CONTINUATION	-$193,925
														Subtotal = $378,118

Issue Date FY: 2011 ( Subtotal = $374,811 )
2011	2011	UNIVERSITY OF TENNESSEE CENTER FOR THE HEALTH SCIENCES	62 SOUTH DUNLAP STREET	MEMPHIS	TN	38103	SHELBY	USA	Allergy and Infectious Diseases Research	000	2	7/21/2011	NON-COMPETING CONTINUATION	$374,811
														Subtotal = $374,811

Issue Date FY: 2010 ( Subtotal = $405,798 )
2010	2010	UNIVERSITY OF TENNESSEE CENTER FOR THE HEALTH SCIENCES	62 SOUTH DUNLAP STREET	MEMPHIS	TN	38103	SHELBY	USA	Allergy and Infectious Diseases Research	000	1	6/25/2010	NEW	$405,798
														Subtotal = $405,798

Grand Total All Awards = $6,754,144

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Novel Antigen Identification for an enterotoxigenic E coli vaccine

Award Number: R01AI089894

ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 07/01/2010

PERIOD OF PERFORMANCE END DATE: 02/28/2026

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