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Extracellular Matix Adhesins of Treponema pallidum

Award Number: R01AI051334
ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 04/15/2002
PERIOD OF PERFORMANCE END DATE: 11/30/2018

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Extracellular Matix Adhesins of Treponema pallidum - DESCRIPTION (provided by applicant): Syphilis remains a public health threat worldwide, with an estimated 12 million new infections per year and a global burden of 25 million infections. Within the last decade there has been an increase in syphilis outbreaks in major cities around the world, with a 10-fold increase in syphilis infections documented for China and Canada and a doubling of syphilis infections in the United States. Syphilis infections increase the risk of acquiring and transmitting HIV, and there has been a 23% increase in congenital syphilis infections, resulting from mother to child transmission in utero, in recent years within the United States. Although syphilis is curable with penicillin treatment if diagnosed early, the worldwide syphilis prevalence shows that elimination of this disease will not occur through public health control measures alone, and instead will require development of an effective syphilis vaccine. Development of a syphilis vaccine requires an in depth knowledge of the pathogenic mechanisms used by this highly successful pathogen. The bacterium that causes syphilis, Treponema pallidum, is able to disseminate rapidly within the host during the early stages of infection to infect every organ and tissue. The pathogenic mechanisms used by T. pallidum to undergo widespread dissemination throughout the host are not known, and gaining understanding within this highly relevant area of study will reveal novel vaccine candidates that can be targeted to prevent establishment of infection. The long-term objective of the research project is to elucidate the mechanisms that facilitate attachment of T. pallidum to host components and widespread treponemal dissemination and, specifically, to determine the role of two T. pallidum proteases, pallilysin and Tp0750, in this important pathogenic process. To accomplish this objective, the following specific aims are proposed: (1) to elucidate the mechanism of host component attachment and proteolysis for pallilysin and Tp0750; (2) to determine the ability of these two proteases to exploit the host fibrinolytic process that is essential for normal host component degradation and turnover; (3) to use sensitive proteomic methodologies and a "model" treponeme to determine the location of these two proteases within T. pallidum; and (4) to directly determine the role these two proteases play in dissemination of T. pallidum. These studies will increase understanding of the critical process of T. pallidum dissemination and will reveal suitable vaccine candidates for prevention of syphilis infection.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2019 ( Subtotal = -$131,416 )
2019	2017	UNIVERSITY OF VICTORIA	3800 FINNERTY RD	VICTORIA	BC	V8P 5C2		CAN	Allergy and Infectious Diseases Research	001	14	4/2/2019	NON-COMPETING CONTINUATION	-$131,416
2019	2017	UNIVERSITY OF VICTORIA	3800 FINNERTY RD	VICTORIA	BC	V8P 5C2		CAN	Allergy and Infectious Diseases Research	000	14	11/28/2018	NON-COMPETING CONTINUATION	$0
														Subtotal = -$131,416

Issue Date FY: 2017 ( Subtotal = $232,650 )
2017	2017	UNIVERSITY OF VICTORIA	3800 FINNERTY RD	VICTORIA	BC	V8P 5C2		CAN	Allergy and Infectious Diseases Research	000	14	1/23/2017	NON-COMPETING CONTINUATION	$232,650
														Subtotal = $232,650

Issue Date FY: 2016 ( Subtotal = $236,542 )
2016	2016	UNIVERSITY OF VICTORIA	POST BOX 1700	VICTORIA, B C				CAN	Allergy and Infectious Diseases Research	000	13	1/15/2016	NON-COMPETING CONTINUATION	$236,542
														Subtotal = $236,542

Issue Date FY: 2015 ( Subtotal = $241,687 )
2015	2015	UNIVERSITY OF VICTORIA	POST BOX 1700	VICTORIA, B C				CAN	Allergy and Infectious Diseases Research	000	12	1/22/2015	NON-COMPETING CONTINUATION	$241,687
														Subtotal = $241,687

Issue Date FY: 2014 ( Subtotal = $249,802 )
2014	2014	UNIVERSITY OF VICTORIA	POST BOX 1700	VICTORIA, B C				CAN	Allergy and Infectious Diseases Research	001	11	6/5/2014	NON-COMPETING CONTINUATION	$24,981
2014	2014	UNIVERSITY OF VICTORIA	POST BOX 1700	VICTORIA, B C				CAN	Allergy and Infectious Diseases Research	000	11	1/7/2014	NON-COMPETING CONTINUATION	$224,821
														Subtotal = $249,802

Issue Date FY: 2013 ( Subtotal = $239,286 )
2013	2013	UNIVERSITY OF VICTORIA	POST BOX 1700	VICTORIA, B C				CAN	Allergy and Infectious Diseases Research	002	10	6/13/2013	COMPETING CONTINUATION	$10,182
2013	2013	UNIVERSITY OF VICTORIA	POST BOX 1700	VICTORIA, B C				CAN	Allergy and Infectious Diseases Research	000	10	2/8/2013	COMPETING CONTINUATION	$229,104
2013	2013	UNIVERSITY OF VICTORIA	POST BOX 1700	VICTORIA, B C		00000		CAN	Allergy and Infectious Diseases Research	003	10	8/27/2013	COMPETING CONTINUATION	$0
2013	2011	UNIVERSITY OF VICTORIA	POST BOX 1700	VICTORIA, B C		00000		CAN	Allergy and Infectious Diseases Research	001	9	2/8/2013	NON-COMPETING CONTINUATION	$0
														Subtotal = $239,286

Issue Date FY: 2012 ( Subtotal = $0 )
2012	2011	UNIVERSITY OF VICTORIA	POST BOX 1700	VICTORIA, B C		00000		CAN	Allergy and Infectious Diseases Research	000	9	3/19/2012	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2011 ( Subtotal = $233,640 )
2011	2011	UNIVERSITY OF VICTORIA	POST BOX 1700	VICTORIA, B C				CAN	Allergy and Infectious Diseases Research	000	9	4/25/2011	NON-COMPETING CONTINUATION	$212,399
2011	2011	UNIVERSITY OF VICTORIA	POST BOX 1700	VICTORIA, B C				CAN	Allergy and Infectious Diseases Research	001	9	6/10/2011	NON-COMPETING CONTINUATION	$21,241
														Subtotal = $233,640

Issue Date FY: 2010 ( Subtotal = $238,422 )
2010	2010	UNIVERSITY OF VICTORIA	POST BOX 1700	VICTORIA, B C				CAN	Allergy and Infectious Diseases Research	000	8	4/7/2010	NON-COMPETING CONTINUATION	$238,422
														Subtotal = $238,422

Issue Date FY: 2009 ( Subtotal = $240,045 )
2009	2009	UNIVERSITY OF VICTORIA	POST BOX 1700	VICTORIA, B C				CAN	Allergy and Infectious Diseases Research	000	7	6/2/2009	NON-COMPETING CONTINUATION	$240,045
														Subtotal = $240,045

Issue Date FY: 2007 ( Subtotal = $244,327 )
2007	2007	UNIVERSITY OF VICTORIA	POST BOX 1700	VICTORIA, B C		00000		CAN	Allergy and Infectious Diseases Research	000	5	4/30/2007	COMPETING CONTINUATION	$244,327
														Subtotal = $244,327

Issue Date FY: 2005 ( Subtotal = $260,140 )
2005	2005	UNIVERSITY OF WASHINGTON	3917 UNIVERSITY WAY NE	SEATTLE	WA	98105	KING	USA	Microbiology and Infectious Diseases Research	000	4	2/9/2005	NON-COMPETING CONTINUATION	$260,140
														Subtotal = $260,140

Issue Date FY: 2004 ( Subtotal = $260,140 )
2004	2004	UNIVERSITY OF WASHINGTON	3917 UNIVERSITY WAY NE	SEATTLE	WA	98195	KING	USA	Microbiology and Infectious Diseases Research	000	3	3/19/2004	NON-COMPETING CONTINUATION	$260,140
														Subtotal = $260,140

Issue Date FY: 2003 ( Subtotal = $260,140 )
2003	2003	UNIVERSITY OF WASHINGTON	3917 UNIVERSITY WAY NE	SEATTLE	WA	98195	KING	USA	Microbiology and Infectious Diseases Research	000	2		NON-COMPETING CONTINUATION	$260,140
														Subtotal = $260,140

Issue Date FY: 2002 ( Subtotal = $257,720 )
2002	2002	UNIVERSITY OF WASHINGTON	3917 UNIVERSITY WAY NE	SEATTLE	WA	98195	KING	USA	Microbiology and Infectious Diseases Research	000	1	4/11/2002	NEW	$257,720
														Subtotal = $257,720

Grand Total All Awards = $3,063,125

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Extracellular Matix Adhesins of Treponema pallidum

Award Number: R01AI051334

ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 04/15/2002

PERIOD OF PERFORMANCE END DATE: 11/30/2018

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