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REGULATION OF FLAGELLUM AND PFT IN LEISHMANIA

Award Number: R01AI047909
ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/01/2000
PERIOD OF PERFORMANCE END DATE: 05/31/2005

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REGULATION OF FLAGELLUM AND PFT IN LEISHMANIA - The overall issue addressed by this proposal is to understand regulatory processes governing stage-specific elaboration of the flagellum in Leishmania mexicana. A profound change in flagellar morphology is one of the features distinguishing the insect and mammalian stages of the human pathogen Leishmania. Despite classical recognition of these changes in flagellar morphology occurring curing the life cycle, very little is known about how the structural components of the flagellum are assembled and disassembled in correspondence with the life cycle. Focusing on the paraflagellar rod, this proposal describes experiments to study the regulatory mechanisms deployed by these parasites to control production and demolition of the flagellum and to understand the role played by this motility organelle in the biology of the organism. We will explore regulation at the level of mRNA production, translation, protein transport to the parasites' biology could reveal new targets for antiparasitic therapies. The functional importance of the PFR coupled with its proven potential as a vaccine candidate justify a more complete characterization of this complex structure.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2004 ( Subtotal = $295,908 )
2004	2004	PURDUE RESEARCH FOUNDATION	SPONS PROGRAMS-1063 HOVDE HALL	WEST LAFAYETTE	IN	47907	TIPPECANOE	USA	Microbiology and Infectious Diseases Research	000	5	5/14/2004	NON-COMPETING CONTINUATION	$295,908
														Subtotal = $295,908

Issue Date FY: 2003 ( Subtotal = $296,611 )
2003	2003	PURDUE RESEARCH FOUNDATION	SPONS PROGRAMS-1063 HOVDE HALL	WEST LAFAYETTE	IN	47907	TIPPECANOE	USA	Microbiology and Infectious Diseases Research	000	4	5/22/2003	NON-COMPETING CONTINUATION	$296,611
														Subtotal = $296,611

Issue Date FY: 2002 ( Subtotal = $235,012 )
2002	2002	PURDUE RESEARCH FOUNDATION	SPONS PROGRAMS-1063 HOVDE HALL	WEST LAFAYETTE	IN	47907	TIPPECANOE	USA	Microbiology and Infectious Diseases Research	000	3	9/9/2002	NON-COMPETING CONTINUATION	$235,012
														Subtotal = $235,012

Issue Date FY: 2001 ( Subtotal = $281,718 )
2001	2001	PURDUE RESEARCH FOUNDATION	SPONS PROGRAMS-1063 HOVDE HALL	WEST LAFAYETTE	IN	47907	TIPPECANOE	USA	Microbiology and Infectious Diseases Research	000	2	8/8/2001	NON-COMPETING CONTINUATION	$281,718
														Subtotal = $281,718

Issue Date FY: 2000 ( Subtotal = $285,261 )
2000	2000	PURDUE RESEARCH FOUNDATION	610 PURDUE HALL	WEST LAFAYETTE	IN	47907	TIPPECANOE	USA	Microbiology and Infectious Diseases Research	000	1	8/25/2000	NEW	$285,261
														Subtotal = $285,261

Grand Total All Awards = $1,394,510

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REGULATION OF FLAGELLUM AND PFT IN LEISHMANIA

Award Number: R01AI047909

ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/01/2000

PERIOD OF PERFORMANCE END DATE: 05/31/2005

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