Thursday, December 26, 2024 12/26/2024

Salmonella Host interactions

Award Number: R01AI044170
ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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PROJECT SUMMARY Typhoid and paratyphoid fever are indistinguishable in their symptoms, suggesting that typhoidal Salmonella serovars possess similar virulence strategies. However, the identity of shared virulence strategies that set typhoidal Salmonella serovars apart from non-typhoidal Salmonella serovars, such as S. enterica serovar Typhimurium, remain understudied. Experiments proposed in this application are aimed at addressing this important gap in knowledge. Our long-range goal is to elucidate the molecular mechanisms by which typhoidal Salmonella serotypes manipulate host responses during infection. The objectives of this application are to study the contribution of genome decay in typhoidal Salmonella serovars, which includes gene deletion or disruption (pseudogene formation), to their interaction with the human host. Our central hypothesis is that genome decay in typhoidal Salmonella serovars is a key driver of immune evasion. To test our hypothesis, we will determine whether pseudogen formation enables S. Paratyphi A to evade complement activation (specific aim 1), determine how reduced epithelial invasion caused by genome decay moderates gut inflammation (specific aim 2) and determine how pseudogene formation enhances Peyer's patch colonization (specific aim 3). Our analysis of virulence mechanisms shared among typhoidal Salmonella serovars will be useful, and necessary, to understand how the interplay between pathogen and the innate immune system gives rise to responses that distinguish typhoid/paratyphoid fever from gastroenteritis, thereby ushering in a significant conceptual advance.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $601,256 )
2025	2025	UNIVERSITY OF CALIFORNIA, DAVIS	1850 RESEARCH PARK DR STE 300	DAVIS	CA	95618	YOLO	USA	Allergy and Infectious Diseases Research	001	26	11/18/2024	COMPETING CONTINUATION	$601,256
2025	2022	UNIVERSITY OF CALIFORNIA, DAVIS	1850 RESEARCH PARK DR STE 300	DAVIS	CA	95618	YOLO	USA	Allergy and Infectious Diseases Research	000	25	10/29/2024	NON-COMPETING CONTINUATION	$0
														Subtotal = $601,256

Issue Date FY: 2022 ( Subtotal = $495,539 )
2022	2022	UNIVERSITY OF CALIFORNIA, DAVIS	1850 RESEARCH PARK DR, STE 300	DAVIS	CA	95618	YOLO	USA	Allergy and Infectious Diseases Research	000	25	3/17/2022	NON-COMPETING CONTINUATION	$495,539
														Subtotal = $495,539

Issue Date FY: 2021 ( Subtotal = $495,539 )
2021	2021	UNIVERSITY OF CALIFORNIA, DAVIS	1850 RESEARCH PARK DR, STE 300	DAVIS	CA	95618	YOLO	USA	Allergy and Infectious Diseases Research	000	24	3/11/2021	NON-COMPETING CONTINUATION	$495,539
														Subtotal = $495,539

Issue Date FY: 2020 ( Subtotal = $495,539 )
2020	2020	UNIVERSITY OF CALIFORNIA, DAVIS	1850 RESEARCH PARK DR, STE 300	DAVIS	CA	95618	YOLO	USA	Allergy and Infectious Diseases Research	000	23	3/10/2020	NON-COMPETING CONTINUATION	$495,539
														Subtotal = $495,539

Issue Date FY: 2019 ( Subtotal = $495,539 )
2019	2019	UNIVERSITY OF CALIFORNIA, DAVIS	1850 RESEARCH PARK DR, STE 300	DAVIS	CA	95618	YOLO	USA	Allergy and Infectious Diseases Research	000	22	3/10/2019	NON-COMPETING CONTINUATION	$495,539
														Subtotal = $495,539

Issue Date FY: 2018 ( Subtotal = $491,615 )
2018	2018	UNIVERSITY OF CALIFORNIA, DAVIS	1850 RESEARCH PARK DR, STE 300	DAVIS	CA	95618	YOLO	USA	Allergy and Infectious Diseases Research	000	21	1/10/2018	COMPETING CONTINUATION	$491,615
2018	2017	UNIVERSITY OF CALIFORNIA, DAVIS	1850 RESEARCH PARK DR, STE 300	DAVIS	CA	95618	YOLO	USA	Allergy and Infectious Diseases Research	001	20	8/9/2018	NON-COMPETING CONTINUATION	$0
														Subtotal = $491,615

Issue Date FY: 2017 ( Subtotal = $443,988 )
2017	2017	UNIVERSITY OF CALIFORNIA, DAVIS	1850 RESEARCH PARK DR, STE 300	DAVIS	CA	95618	YOLO	USA	Allergy and Infectious Diseases Research	000	20	3/23/2017	NON-COMPETING CONTINUATION	$443,988
														Subtotal = $443,988

Issue Date FY: 2016 ( Subtotal = $443,988 )
2016	2016	UNIVERSITY OF CALIFORNIA	1850 RESEARCH PARK DRIVE	DAVIS	CA	95618	YOLO	USA	Allergy and Infectious Diseases Research	000	19	3/8/2016	EXTENSION WITH OR WITHOUT FUNDS	$443,988
														Subtotal = $443,988

Issue Date FY: 2015 ( Subtotal = $443,988 )
2015	2015	UNIVERSITY OF CALIFORNIA	1850 RESEARCH PARK DRIVE	DAVIS	CA	95618	YOLO	USA	Allergy and Infectious Diseases Research	000	18	3/17/2015	NON-COMPETING CONTINUATION	$443,988
														Subtotal = $443,988

Issue Date FY: 2014 ( Subtotal = $443,988 )
2014	2014	UNIVERSITY OF CALIFORNIA	1850 RESEARCH PARK DRIVE	DAVIS	CA	95618	YOLO	USA	Allergy and Infectious Diseases Research	000	17	3/17/2014	NON-COMPETING CONTINUATION	$443,988
														Subtotal = $443,988

Issue Date FY: 2013 ( Subtotal = $417,349 )
2013	2013	UNIVERSITY OF CALIFORNIA	1441 RESEARCH PARK DRIVE	DAVIS	CA	95616	YOLO	USA	Allergy and Infectious Diseases Research	001	16	6/4/2013	COMPETING CONTINUATION	$17,759
2013	2013	UNIVERSITY OF CALIFORNIA	1441 RESEARCH PARK DRIVE	DAVIS	CA	95616	YOLO	USA	Allergy and Infectious Diseases Research	000	16	1/9/2013	COMPETING CONTINUATION	$399,590
														Subtotal = $417,349

Issue Date FY: 2012 ( Subtotal = $368,743 )
2012	2012	UNIVERSITY OF CALIFORNIA	1441 RESEARCH PARK DRIVE	DAVIS	CA	95616	YOLO	USA	Allergy and Infectious Diseases Research	000	15	3/20/2012	NON-COMPETING CONTINUATION	$368,743
														Subtotal = $368,743

Issue Date FY: 2011 ( Subtotal = $368,743 )
2011	2011	UNIVERSITY OF CALIFORNIA	1441 RESEARCH PARK DRIVE	DAVIS	CA	95616	YOLO	USA	Allergy and Infectious Diseases Research	001	14	6/9/2011	NON-COMPETING CONTINUATION	$33,522
2011	2011	UNIVERSITY OF CALIFORNIA	1441 RESEARCH PARK DRIVE	DAVIS	CA	95616	YOLO	USA	Allergy and Infectious Diseases Research	000	14	3/10/2011	NON-COMPETING CONTINUATION	$335,221
														Subtotal = $368,743

Issue Date FY: 2010 ( Subtotal = $372,468 )
2010	2010	UNIVERSITY OF CALIFORNIA	1441 RESEARCH PARK DRIVE	DAVIS	CA	95616	YOLO	USA	Allergy and Infectious Diseases Research	000	13	3/24/2010	NON-COMPETING CONTINUATION	$372,468
														Subtotal = $372,468

Issue Date FY: 2009 ( Subtotal = $376,231 )
2009	2009	UNIVERSITY OF CALIFORNIA	1441 RESEARCH PARK DRIVE	DAVIS	CA	95616	YOLO	USA	Allergy and Infectious Diseases Research	001	12	6/3/2009	NON-COMPETING CONTINUATION	$37,623
2009	2009	UNIVERSITY OF CALIFORNIA	1441 RESEARCH PARK DRIVE	DAVIS	CA	95616	YOLO	USA	Allergy and Infectious Diseases Research	000	12	3/17/2009	NON-COMPETING CONTINUATION	$338,608
														Subtotal = $376,231

Issue Date FY: 2008 ( Subtotal = $376,231 )
2008	2008	UNIVERSITY OF CALIFORNIA	1441 RESEARCH PARK DRIVE	DAVIS	CA	95616	YOLO	USA	Allergy and Infectious Diseases Research	000	11	3/12/2008	COMPETING CONTINUATION	$376,231
														Subtotal = $376,231

Issue Date FY: 2007 ( Subtotal = $238,158 )
2007	2007	UNIVERSITY OF CALIFORNIA	1441 RESEARCH PARK DRIVE	DAVIS	CA	95616	YOLO	USA	Allergy and Infectious Diseases Research	000	10	11/16/2006	NON-COMPETING CONTINUATION	$238,158
														Subtotal = $238,158

Issue Date FY: 2006 ( Subtotal = $245,464 )
2006	2006	UNIVERSITY OF CALIFORNIA	1441 RESEARCH PARK DRIVE	DAVIS	CA	95616	YOLO	USA	Allergy and Infectious Diseases Research	000	9	11/16/2005	NON-COMPETING CONTINUATION	$245,464
														Subtotal = $245,464

Issue Date FY: 2005 ( Subtotal = $291,384 )
2005	2005	UNIVERSITY OF CALIFORNIA	1441 RESEARCH PARK DRIVE	DAVIS	CA	95616	YOLO	USA	Microbiology and Infectious Diseases Research	000	8	8/8/2005	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$219,268
2005	2005	TEXAS A & M UNIVERSITY RESEARCH FOUNDATION	POST OFFICE BOX 3578	COLLEGE STATION	TX	77843	BRAZOS	USA	Microbiology and Infectious Diseases Research	000	7	11/30/2004	NON-COMPETING CONTINUATION	$72,116
														Subtotal = $291,384

Issue Date FY: 2004 ( Subtotal = $291,000 )
2004	2004	TEXAS A & M UNIVERSITY RESEARCH FOUNDATION	POST OFFICE BOX 3578	COLLEGE STATION	TX	77843	BRAZOS	USA	Microbiology and Infectious Diseases Research	000	6	12/8/2003	NON-COMPETING CONTINUATION	$291,000
														Subtotal = $291,000

Issue Date FY: 2003 ( Subtotal = $145,500 )
2003	2003	TEXAS A & M UNIVERSITY RESEARCH FOUNDATION	POST OFFICE BOX 3578	COLLEGE STATION	TX	77843	BRAZOS	USA	Microbiology and Infectious Diseases Research	000	5	6/5/2003	COMPETING CONTINUATION	$145,500
														Subtotal = $145,500

Issue Date FY: 2002 ( Subtotal = $256,476 )
2002	2002	TEXAS A & M UNIVERSITY RESEARCH FOUNDATION	POST OFFICE BOX 3578	COLLEGE STATION	TX	77843	BRAZOS	USA	Microbiology and Infectious Diseases Research	000	4	4/15/2002	NON-COMPETING CONTINUATION	$256,476
														Subtotal = $256,476

Grand Total All Awards = $9,360,566

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Salmonella Host interactions

Award Number: R01AI044170

ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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