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T resident memory in the lung

Award Number: R01AI042767
ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 04/01/1998
PERIOD OF PERFORMANCE END DATE: 10/31/2023

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View Award Description

T resident memory in the lung - Program Director/Principal Investigator (Last, First, Middle): Harty, John T. Influenza infection is a major public health menace and our current strategies of seasonal influenza vaccination provide suboptimal protection. Thus, it is critical to provide basic, mechanistic insights into the possibility of universal influenza vaccines. In the absence of neutralizing antibodies, the presence of IAV-specific memory CD8 T cells targeting conserved viral proteins such as NP or M2, which are maintained systemically as well as in the lung correlate with control of viral titers and reduction of disease symptoms in humans. Mouse models confirm the potency of IAV specific memory CD8 T cells to provide strain-transcending heterosubtypic immunity, but also suggest it is the lung resident memory CD8 T cells (Trm) that enable swift and robust protection against IAV infection. Thus, establishing a robust long-term Trm population in the lung may be an important goal for an IAV vaccine. However, evidence from our own lab and others shows that lung Trm gradually wane in numbers with time, resulting in a loss of protective immunity. Our long-term goal is to understand the biology of IAV-induced Trm and how these cells can be manipulated to enhance immunity. We will address this long-term goal with the following specific aims: Specific Aim 1. Dissect the metabolic and genetic factors underlying compromised Trm survival in the lung compared to skin. Specific Aim 2. Determine if lung Trm can be efficiently restored by boosting and the consequences on lung physiology and protection from IAV. Specific Aim 3. Visualize the dynamics of Trm responses to secondary infection in lung OMB No. 0925-0001/0002 (Rev. 03/16 Approved Through 10/31/2018) Page Continuation Format Page


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = -$198 )
2024	2023	THE UNIVERSITY OF IOWA	105 JESSUP HALL	IOWA CITY	IA	52242	JOHNSON	USA	Allergy and Infectious Diseases Research	000	24	7/3/2024	NON-COMPETING CONTINUATION	-$198
														Subtotal = -$198

Issue Date FY: 2023 ( Subtotal = $521,974 )
2023	2023	UNIVERSITY OF IOWA, THE	105 JESSUP HALL	IOWA CITY	IA	52242	JOHNSON	USA	Allergy and Infectious Diseases Research	000	24	10/17/2022	NON-COMPETING CONTINUATION	$521,974
														Subtotal = $521,974

Issue Date FY: 2022 ( Subtotal = $521,974 )
2022	2022	UNIVERSITY OF IOWA, THE	105 JESSUP HALL	IOWA CITY	IA	52242	JOHNSON	USA	Allergy and Infectious Diseases Research	000	23	10/22/2021	NON-COMPETING CONTINUATION	$521,974
														Subtotal = $521,974

Issue Date FY: 2021 ( Subtotal = $521,974 )
2021	2021	UNIVERSITY OF IOWA, THE	105 JESSUP HALL	IOWA CITY	IA	52242	JOHNSON	USA	Allergy and Infectious Diseases Research	000	22	10/29/2020	NON-COMPETING CONTINUATION	$521,974
														Subtotal = $521,974

Issue Date FY: 2020 ( Subtotal = $521,974 )
2020	2020	UNIVERSITY OF IOWA, THE	105 JESSUP HALL	IOWA CITY	IA	52242	JOHNSON	USA	Allergy and Infectious Diseases Research	001	21	8/3/2020	NON-COMPETING CONTINUATION	$0
2020	2020	UNIVERSITY OF IOWA, THE	105 JESSUP HALL	IOWA CITY	IA	52242	JOHNSON	USA	Allergy and Infectious Diseases Research	000	21	11/14/2019	NON-COMPETING CONTINUATION	$521,974
														Subtotal = $521,974

Issue Date FY: 2019 ( Subtotal = $522,172 )
2019	2019	UNIVERSITY OF IOWA, THE	105 JESSUP HALL	IOWA CITY	IA	52242	JOHNSON	USA	Allergy and Infectious Diseases Research	001	20	5/8/2019	COMPETING CONTINUATION	$198
2019	2019	UNIVERSITY OF IOWA, THE	105 JESSUP HALL	IOWA CITY	IA	52242	JOHNSON	USA	Allergy and Infectious Diseases Research	002	20	7/5/2019	COMPETING CONTINUATION	$0
2019	2019	UNIVERSITY OF IOWA, THE	105 JESSUP HALL	IOWA CITY	IA	52242	JOHNSON	USA	Allergy and Infectious Diseases Research	000	20	11/21/2018	COMPETING CONTINUATION	$521,974
														Subtotal = $522,172

Issue Date FY: 2007 ( Subtotal = $279,713 )
2007	2007	UNIVERSITY OF IOWA	2 GILMORE HALL	IOWA CITY	IA	52242	JOHNSON	USA	Allergy and Infectious Diseases Research	000	9	2/28/2007	NON-COMPETING CONTINUATION	$279,713
														Subtotal = $279,713

Issue Date FY: 2006 ( Subtotal = $288,068 )
2006	2006	UNIVERSITY OF IOWA	ROOM B5K, JESSUP HALL	IOWA CITY	IA	52242	JOHNSON	USA	Allergy and Infectious Diseases Research	000	8	1/17/2006	NON-COMPETING CONTINUATION	$288,068
														Subtotal = $288,068

Issue Date FY: 2005 ( Subtotal = $295,000 )
2005	2005	UNIVERSITY OF IOWA	ROOM B5K, JESSUP HALL	IOWA CITY	IA	52242	JOHNSON	USA	Microbiology and Infectious Diseases Research	000	7	2/17/2005	NON-COMPETING CONTINUATION	$295,000
														Subtotal = $295,000

Issue Date FY: 2004 ( Subtotal = $295,000 )
2004	2004	UNIVERSITY OF IOWA	ROOM B5K, JESSUP HALL	IOWA CITY	IA	52242	JOHNSON	USA	Indicates awards funded from multiple programs	000	6	2/2/2004	NON-COMPETING CONTINUATION	$295,000
														Subtotal = $295,000

Issue Date FY: 2003 ( Subtotal = $119,844 )
2003	2003	UNIVERSITY OF IOWA	ROOM B5K, JESSUP HALL	IOWA CITY	IA	52242	JOHNSON	USA	Indicates awards funded from multiple programs	000	5	8/1/2003	COMPETING CONTINUATION	$119,844
														Subtotal = $119,844

Issue Date FY: 2001 ( Subtotal = $248,055 )
2001	2001	UNIVERSITY OF IOWA	ROOM B5K, JESSUP HALL	IOWA CITY	IA	52242	JOHNSON	USA	Microbiology and Infectious Diseases Research	000	4	3/4/2001	NON-COMPETING CONTINUATION	$248,055
														Subtotal = $248,055

Issue Date FY: 2000 ( Subtotal = $240,832 )
2000	2000	UNIVERSITY OF IOWA	2 GILMORE HALL	IOWA CITY	IA	52242	JOHNSON	USA	Microbiology and Infectious Diseases Research	000	3	3/24/2000	NON-COMPETING CONTINUATION	$240,832
														Subtotal = $240,832

Issue Date FY: 1999 ( Subtotal = $233,817 )
1999	1999	UNIVERSITY OF IOWA	2 GILMORE HALL	IOWA CITY	IA	52242	JOHNSON	USA	Microbiology and Infectious Diseases Research	000	2	2/17/1999	NON-COMPETING CONTINUATION	$233,817
														Subtotal = $233,817

Issue Date FY: 1998 ( Subtotal = $235,651 )
1998	1998	UNIVERSITY OF IOWA	2 GILMORE HALL	IOWA CITY	IA	52242	JOHNSON	USA	Microbiology and Infectious Diseases Research	000	1	7/8/1998	NEW	$235,651
														Subtotal = $235,651

Grand Total All Awards = $4,845,850

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T resident memory in the lung

Award Number: R01AI042767

ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 04/01/1998

PERIOD OF PERFORMANCE END DATE: 10/31/2023

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