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Ultra High-Resolution Multimodal Cross-Disorder Atlas of Neurodegenerative Dementias

Award Number: R01AG100878
ORGANIZATION: NATIONAL INSTITUTE ON AGING
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/15/2026
PERIOD OF PERFORMANCE END DATE: 05/31/2031

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Ultra High-Resolution Multimodal Cross-Disorder Atlas of Neurodegenerative Dementias - Proteinopathies involving tau, TDP-43, and alpha-synuclein define major molecular subtypes of age-associated neurodegenerative dementias, including Alzheimer’s dementia, frontotemporal dementia, progressive supranuclear palsy, and Lewy body dementia. These disorders show region- and cell type-specific aggregation of toxic proteins alongside neuronal loss and cognitive decline, yet the molecular basis for selective vulnerability remains unclear. Our prior work indicates that genetic modifiers are co-regulated in a cell state-specific manner, causing polygenic disease risk to manifest differently across disorders within distinct neural and glial populations. This dynamic, context-dependent regulation suggests that intrinsic and extrinsic cellular factors drive differential susceptibility among disorders with unique genetic risk profiles. Concurrent analysis of these disorders can reveal disorder-specific traits linked to causal factors beyond generalized injury responses. The central hypothesis proposes that distinct cell states shaped by genetic, epigenetic, and organellar differences mediate neuron and glial vulnerability or resilience to tau, TDP-43, and alpha-synuclein proteinopathies. Shared and disorder-specific genetic modifiers converge on organelles like mitochondria and lysosomes, which serve as points of resilience or vulnerability with both shared and disease-specific regulatory roles. Variation in these organelles between cells may underlie differential vulnerability, demonstrated in rodent models but not yet across individuals. The long-term goal is to identify modifiable molecular determinants of selective vulnerability as potential targets for prevention or early intervention. The overall objective is to define and validate transcriptional, epigenetic, and subcellular molecular phenotypes linked to genetic risk factors that distinguish vulnerable from resilient cell types across different age-related proteinopathies of cognition. This work is supported by a multidisciplinary team with expertise in multiomic single nuclear profiling, cellular and subcellular proteomics, iPSC disease models, and neuropathology. Objectives will be pursued through specific research aims.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $674,513 )
2026	2026	UNIVERSITY OF CALIFORNIA, LOS ANGELES	10889 WILSHIRE BLVD STE 700	LOS ANGELES	CA	90024	LOS ANGELES	USA	Aging Research	000	1	9/4/2026	NEW	$674,513
														Subtotal = $674,513

Grand Total All Awards = $674,513

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Ultra High-Resolution Multimodal Cross-Disorder Atlas of Neurodegenerative Dementias

Award Number: R01AG100878

ORGANIZATION: NATIONAL INSTITUTE ON AGING

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/15/2026

PERIOD OF PERFORMANCE END DATE: 05/31/2031

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